Intracapsular pressure and interleukin-1β cytokine in hips with acetabular dysplasia

Abstract

Background and purpose Several studies have demonstrated an increased intracapsular pressure in several hip disorders such as septic arthritis, synovitis, and trauma. We therefore measured the intracapsular pressure in different positions in early dysplasic hips and its relation to the concentration of interleukin-1β (IL-1β), the volume of joint fluid, and the clinical and radiographic findings before a periacetabular osteotomy.Methods 12 female patients (12 hips, mean age 35 (18–52)) with hip dysplasia were investigated. The intracapsular pressure was recorded and we investigated possible correlations with the Harris hip score, the Tönnis scale, radiographic findings, the volume of joint fluid, and the concentration of IL-1β.Results An increased intracapsular pressure was noted, especially in flexion or extension with internal rotation. We found positive correlations between the intracapsular pressure and both the volume of joint fluid and the concentration of IL-1β.Interpretation Increased intracapsular pressure varied with different positions, indicating the presence of synovitis resulting from early osteoarthritis in dysplastic hips. Positive correlations between the pressure and both the concentration of IL-1β and the volume of joint fluid suggest that the inflammatory cytokines produced by the synovial membrane as a consequence of mechanical instability of the hip joint may be of importance for the initiation and/or development of osteoarthritis in dysplastic hips.

sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment – A feasible approach for autologous stem cell based osteoarthritic cartilage repair

“…Xie et al . reported that the mean concentration of IL-1β in synovial fluid from early osteoarthritis in dysplastic hips was 55 (SD 12), ranging from 24 to 74 pg/mL [26]. Attur et al .…”

Synovial joint fluid cytokine levels in hip disease

“…However, there were few reports concerning cytokine levels in the hip joint. Although hip joint fluid IL-1b levels with acetabular dysplasia have been measured, the samples were collected after injection of 10 ml of saline inside the joint capsule [15]. Therefore they did not have an accurate cytokine level.…”

“…Thus inflammatory cytokines have been proposed to play a role in joint destruction in hip disease. Cytokines have been reported in the synovial fluid of diseased knees [6,7]; however, there have been few studies concerning the synovial joint fluid cytokine levels of diseased hips [15,16]. No study has evaluated the relationship between the severity of hip joint destruction and hip joint synovial fluid cytokine levels.…”

Ratio of the Medial Hip Joint Space as a Predictor for Collapse of the Femoral Head in Non-traumatic Osteonecrosis: A Retrospective Study and Finite Element Analysis

“…And the resulting insu cient blood supply to the femoral head and impaired venous return can, in turn, affect the repair of ONFH. Similarly, some studies demonstrate that less acetabular coverage can increase intracapsular pressure, and excessive weight bearing suffered by the hip joint can contribute to the development of ONFH [23][24][25][26]. Junfeng Zeng et al [27] nd that less acetabular coverage may be associated with the development of ONFH in East Asian population, which is also a factor affecting the repair of ONFH.…”