• Pulmonary artery constriction has been utilized as an experimental method of stressing the right ventricle 1 " 4 or producing changes in the systemic circulation.
"7 As a result, the basic circulatory features of pulmonary artery constriction have been documented. The murmur that is produced by this procedure has not received as much attention. It therefore seemed desirable to investigate this aspect of pulmonary artery constriction. The purpose of this report is to summarize these observations.
MethodsDogs were anesthetized with intravenous sodium pentobarbital (30 ing. per Kg.) and the chest opened using a sternal-splitting procedure under mild positive pressure respiration. The right ventricle was cannulated through the azygos vein and the left pulmonary artery via a side branch. A phonocatheter* was also placed in the pulmonary artery by way of a second side branch. This was connected to a Electronics-for-Medicine logarithmic heart sound amplifier. Right ventricular and pulmonary artery pressures were measured electrically using Stathani strain gauges and, together with the intrapulmonary sounds, were recorded photographically using 1 both an Electronics-for-Medicine recorder and a Sanborn twin-beam recorder. Respirations were interrupted during all recordings to avoid artifacts due to lung inflation. The zero level for nil pressure recordings was the level of the right atrium.A ligature was placed around the base of the main pulmonary artery and attached to a screw device similar to that described by Finberg and Wiggers.1 By tightening this instrument, the loop around the pulmonary artery was reduced in size. This instrument was calibrated so that the reduction in the size of the loop was known for each From the Department of Physiology, Seton Hall College of Medicine and Dentistry, Jersey City, New Jersey.Supported in part by a grant from the American Heart Association and from the Burlington County Heart Association.'Manufactured by American Electronic Laboratories, Inc., Philadelphia, Pennsylvania.setting. In addition, immediately following each experiment, the segment of the pulmonary artery containing the stenosis was removed without disturbing the ligature, and the internal diameter was measured for each degree of constriction utilized in that study. As a result, it was possible to quantitate with considerable accuracy the internal cross sectional area of the constriction that was produced in the pulmonary artery by each setting. During a typical experiment the ligature was tightened. Sound and pressure recordings were made and other data obtained. The ligature was then loosened to permit a recovery period before the procedure was repeated at an increased degree of constriction.Cardiac output was determined in some animals during each of the experimental procedures. The dye-dilution technique, as modified by Opdyke and Sniffen, 8 was utilized with tricarbocyanine dye (Cardio-Green*) as the indicator. The dye was injected into the right atrium via a cannula in the right jugular vein, and blood was wi...