Intracardiac thrombus formation in cardiac impairment: the role of anticoagulant therapy

Lip, Gregory Y.H.

doi:10.1136/pgmj.72.854.731

Cited by 41 publications

(21 citation statements)

References 59 publications

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“…11 Currently, in literature the only clear-cut indications for anticoagulation in most patients with dilated cardiomyopathy are atrial fibrillation, a previous thromboembolic event, or LV thrombus.…”

Section: Discussionmentioning

confidence: 99%

Thromboembolic Complications in Patients With Newly Diagnosed Dilated Cardiomyopathy Immediately After Initiation of Congestive Heart Failure Treatment: Just a Coincidence or Should We Pay More Attention?

Yetkın¹,

Topal²,

Yanık³

et al. 2009

Clin Appl Thromb Hemost

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Recently, we have experienced cerebrovascular embolic events in 2 consecutive patients in our outpatient clinic. Accordingly, we want to share our comments with literature on these 2 patients. Both patients had newly diagnosed left ventricular (LV) dysfunction, sinus rhythm, and cerebrovascular event within the first week after initiation of heart failure treatment. Although, our cases are not enough to make a general statement or conclusion, we can recommend that patients with newly diagnosed severe LV dysfunction with normal sinus rhythm and without echocardiographically visible thrombus should also be closely followed up for thromboembolic complications at least during the first weeks of congestive heart failure treatment.

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Section: Discussionmentioning

confidence: 99%

Thromboembolic Complications in Patients With Newly Diagnosed Dilated Cardiomyopathy Immediately After Initiation of Congestive Heart Failure Treatment: Just a Coincidence or Should We Pay More Attention?

Yetkın¹,

Topal²,

Yanık³

et al. 2009

Clin Appl Thromb Hemost

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show abstract

“…Cerrahiye uygun olmayan ve riskli hastalarda trombolitik tedavi önemli bir alternatiftir. 6,7 Akut miyokard infarktüsü, periferik arter tıkanıklığı, kalp kapak trombozu ve akut pulmoner embolide trombolitik tedavi etkin ve yaygın şekilde kullanılmaktadır. [8][9][10] Yeni oluşmuş trombüslerde daha etkin olmak üzere, sol ventrikül trombüslerinin trombolitik tedavi ile çözüldüğü bildirilmiştir.…”

Section: Discussionunclassified

Successful Lysis of a Left Ventricular Apical Thrombus by Thrombolitic Therapy:Case Reports

Bayramoğlu¹,

Günaydın²,

Bektaş³

et al. 2016

Turkiye Klinikleri J Case Rep

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Ö ÖZ ZE ET T Sol ventrikül içerisinde gelişmiş olan trombüslerin tedavisinde net bir yaklaşım bulunmamaktadır. Emboli riski yüksek ve cerrahi müdahalenin mümkün olmadığı sol ventrikül trombüsle-rinde trombolitik tedavi uygulanabilmektedir. Sol ventrikül trombüslerinde trombolitik doz şeması ve infüzyon süresi ile ilgili net bir bilgi bulunmamaktadır. Ankilozan spondilit nedeni ile takip edilen 37 yaşındaki erkek olgu, 3 gün önce başlayan nefes darlığı şikâyeti ile başvurdu. Ekokardiyografisinde sol ventrikül sistolik fonksiyonlarında azalma ve sol ventrikül apeksinde hareketli trombüs saptandı. Olguya yüksek cerrahi risk nedeni ile 100 mg t-PA verilmesi planlandı. İnfüz-yonun dördüncü saatinde yapılan ekokardiyografide trombüsün tamamen kaybolduğu görüldü. Tedavi dozu ve infüzyon süresini belirlemede erken ve sık aralıklı ekokardiyografik değerlendirme etkili bir seçenek olabilir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Ekokardiyografi; tromboz A AB BS S T TR RA AC CT T There is no a clear approach in the treatment of thrombus in the left ventricle, thrombolytic therapy can be performed in left ventricular thrombi with high risk of embolism and inappropriate surgical intervention. There is no clear information on dosage schedule and duration of thrombolytic infusion in left ventricular thrombi. 37 years-old-man who had ankylosing spondylitis was admitted to our department with dispne. Decreased left ventricular systolic function and a mobile thrombus were detected on echocardiogram. Administration of 100 mg t-PA was planned due to the high risk of surgery. Thrombus dissolution was seen at fourth hour after infusion on echocardiography. Early echocardiographic assessment can be an effective option for determination of treatment dose and infusion time. Adil BAYRAMOĞLU, 1 Antikoagülan tedaviler ve cerrahi prosedürler uygulanabilmektedir. Yüksek sistemik emboli riski taşıyan ve cerrahi tedavinin kontrendike olduğu durumlarda trombolitik tedavi düşünülmelidir.2-4 Trombolitik tedavinin dozu ve infüzyon süresi tartışmalıdır. Bu çalışmada, sol ventrikül apeksinde saptanan intraventriküler trombüsün düşük doz ve kısa süreli doku plazminojen aktivatörü (t-PA) infüzyonu ile tamamen çözüldüğü, trombolitik tedavi infüzyon süresi erken dönem ve sık aralıklarla yapılan

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“…[1]. Yokota et al [2] reported that 19 out of 57 patients with dilated cardiomyopathy developed cardiac thrombus.…”

mentioning

confidence: 97%

Echocardiographic change of a large left ventricular thrombus during resolution

Hwang

Chen

et al. 2004

International Journal of Cardiology

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Intracardiac thrombus formation in cardiac impairment: the role of anticoagulant therapy

Cited by 41 publications

References 59 publications

Thromboembolic Complications in Patients With Newly Diagnosed Dilated Cardiomyopathy Immediately After Initiation of Congestive Heart Failure Treatment: Just a Coincidence or Should We Pay More Attention?

Thromboembolic Complications in Patients With Newly Diagnosed Dilated Cardiomyopathy Immediately After Initiation of Congestive Heart Failure Treatment: Just a Coincidence or Should We Pay More Attention?

Successful Lysis of a Left Ventricular Apical Thrombus by Thrombolitic Therapy:Case Reports

Echocardiographic change of a large left ventricular thrombus during resolution

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