Intracarotid pressure measurements in the evaluation of a computer model of the cerebral circulation

Kailasnath, Purushothaman; Dickey, Phillip S.; Gahbauer, H; Nunes, Judy; Beckman, Charles B.; Chaloupka, John C.

doi:10.1016/s0090-3019(97)00416-3

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…They have also shown that the compensatory mechanisms through the ophthalmic collateral pathways are of lesser importance [15]. A similar model has been applied in individual patients and gave a prediction of stump pressure during carotid endarterectomy [16]. Knowledge of collateral function is of clinical importance in case of an asymptomatic or symptomatic carotid artery stenosis, in decision making regarding extra-intracranial bypass surgery in case of a carotid artery occlusion (to operate or not, based on hemodynamic criteria), and in neurosurgical operations where carotid closure is applied (certain cerebral neoplasms and vascular lesions).…”

Section: Introductionmentioning

confidence: 99%

Clinical applicability of a mathematical model in assessing the functional ability of the communicating arteries of the circle of Willis

Orosz

Hoksbergen

Molnár

et al. 2009

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 99%

Clinical applicability of a mathematical model in assessing the functional ability of the communicating arteries of the circle of Willis

Orosz

Hoksbergen

Molnár

et al. 2009

Journal of the Neurological Sciences

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“…Physical and computational modeling has been used extensively to investigate the properties of vascular systems (Fahrig et al, 1999;Hillen et al, 1986;Kailasnath et al, 1998). Computational fluid dynamic models have the capability to simulate fluid flow in arbitrary geometries, and are suitable for study in complex structures such as the cerebrovascular system.…”

Section: Introductionmentioning

confidence: 99%

A Computational Simulation of the Effect of Hemodilution on Oxygen Transport in Middle Cerebral Artery Vasospasm

Chittiboina

Guthikonda

Wollblad³

et al. 2011

J Cereb Blood Flow Metab

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Cerebral vasospasm after aneurysmal subarachnoid hemorrhage is a potentially severe sequel. The induction of hypertension, hypervolemia, and hemodilution is advocated for vasospasm, but it is unclear whether hemodilution confers any benefit. A finite element model of oxygen transport in the proximal middle cerebral artery (MCA) was used to evaluate the complex relationship among hematocrit, viscosity, oxygen content, and blood flow in the setting of vasospasm. A single-phase non-Newtonian finite element model based on three-dimensional incompressible Navier-Stokes equations was constructed of the M1 segment. The model was solved at vessel stenoses ranging from 0% to 90% and hematocrit from 0.2 to 0.6. A small area of poststenotic recirculation was seen with mild (30%) stenosis. Poststenotic eddy formation was noted with more severe (60% to 90%) stenosis. Volumetric flow was inversely related to hematocrit at mild stenosis (0% to 30%). With near-complete stenosis (90%), a paradoxical increase in flow was seen with increasing hematocrit. Oxygen transport across the segment was related to hematocrit at all levels of stenosis with increasing oxygen transport despite a reduction in blood flow, suggesting that with clinically significant vasospasm in the MCA, hemodilution does not improve oxygen transport, but to the contrary, that ischemia may be worsened.

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“…Linear models were also developed [3][4][5]. Other simplified and 1D models were compared to experimental data or observations [6][7][8][9][10][11][12][13]. Of these models, the Alastruey et al [10] model with compliant vessels compared anatomical variations and occlusions for common CoW geometries.…”

mentioning

confidence: 99%

Modelling of flow through the circle of Willis and cerebral vasculature

Šutalo

Bui

Ahmed

et al. 2009

Modelling in Medicine and Biology VIII

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The blood flow through the circle of Willis was modelled by coupling a Computational Fluid Dynamics (CFD) model of the circle of Willis with a branching tree model of the cerebral vasculature. The cerebral small vascular networks, which often cannot be accurately obtained by medical imaging, were modelled using a branching tree fractal model that accurately simulated the cerebral vasculature geometries and flow. This provided realistic mass flow boundary conditions for the outlet arteries of the circle of Willis.CFD was used to model the three-dimensional transient flow through a simplified and a patient-specific circle of Willis. The patient specific geometry was obtained directly from Computed Tomography (CT) images. A pipe network model was also used to predict the flow through the simplified circle of Willis and the predictions for the flow rates were within 4% of the CFD predictions. The coupled CFD and branching tree model provided useful insight into the variation of the flow through the circle of Willis.

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Intracarotid pressure measurements in the evaluation of a computer model of the cerebral circulation

Cited by 10 publications

References 21 publications

Clinical applicability of a mathematical model in assessing the functional ability of the communicating arteries of the circle of Willis

Clinical applicability of a mathematical model in assessing the functional ability of the communicating arteries of the circle of Willis

A Computational Simulation of the Effect of Hemodilution on Oxygen Transport in Middle Cerebral Artery Vasospasm

Modelling of flow through the circle of Willis and cerebral vasculature

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