Intracavernous alprostadil alfadex (EDEX/VIRIDAL) is effective and safe in patients with erectile dysfunction after failing sildenafil (Viagra)

Shabsigh, Ridwan; Padma‐Nathan, Harin; Gittleman, Marc; McMurray, James G.; Kaufman, Joel M.; Goldstein, Irwin

doi:10.1016/s0090-4295(99)00612-3

Cited by 70 publications

(34 citation statements)

References 5 publications

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“…14 This is comparable to IC PGE 1 doses reported previously. 17,18 The final sildenafil dose was 25 mg in 2% of patients, 50 mg in 30%, and 100 mg in 69%. 14 In total, 32 partners agreed to participate.…”

Section: Resultsmentioning

confidence: 99%

Treatment satisfaction in patients with erectile dysfunction switching from prostaglandin E1 intracavernosal injection therapy to oral sildenafil citrate

Montorsi

Sweeney

et al. 2003

Int J Impot Res

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Section: Resultsmentioning

confidence: 99%

Treatment satisfaction in patients with erectile dysfunction switching from prostaglandin E1 intracavernosal injection therapy to oral sildenafil citrate

Montorsi

Sweeney

et al. 2003

Int J Impot Res

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“…Shabsigh et al reported that alprostadil therapy can be used effectively and safely in 16 Combined sildenafil and ICI therapy has been previously reported as effective salvage therapy for sildenafil non-responders. Twenty nine of 61 patients (47.5%) who failed to respond to sildenafil monotherapy, responded to combined therapy with sildenafil (100 mg) and Trimix ICI with an erection suitable for sexual intercourse.…”

Section: Discussionmentioning

confidence: 99%

High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction

McMahon

2002

Int J Impot Res

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“…Shabsigh et al were able to salvage sildenafil non responders with intracavernosal injections of alprostadil. More than 85% improvement in questions 3 and 4 of the IIEF was recorded [27]. The tri-mix combination (papaverine, phentolamine, alprostadil) is certainly the more efficacious drug treatment for erectile dysfunction and can be used in severe cases of erectile dysfunction when intravernous alprostadil fails or it is not preferable due to side effects.…”

Section: Intracavernosal Injectionsmentioning

confidence: 99%

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy

Hatzimouratidis

Hatzichristou

2004

EAU Update Series

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Oral drug therapy is the first line treatment for erectile dysfunction. Efficacy of oral drugs does not exceed 70%, while drop-out rate is high. Therefore, salvage strategies and second/third line treatment options are necessary to restore erectile function in such patients. The article reviews currently available data and comment on key issues that urologists address on their every day clinical practice.In order to do so, a literature-based critical presentation on the current methodological problems on definition of treatment failure, treatment outcome assessment and alternative therapeutic options was made.Emphasis was given in identifying truly non-responders, as proper instructions for oral drug administration and psychosexual counselling may reverse a substantial number of non-responders to responders. Medication, clinical and patient/partner related issues have been identify that may lead to treatment failure. Treatment outcome assessment based not only on quality of erectile response, but also on side effects profile and patient satisfaction is recommended. Treatment options for truly non-responders include intracavernosal injections, combination therapies, and penile prosthesis. Management strategy however, must identify patient and partner needs and expectations and involve them in the decision-making. #

show abstract

Intracavernous alprostadil alfadex (EDEX/VIRIDAL) is effective and safe in patients with erectile dysfunction after failing sildenafil (Viagra)

Cited by 70 publications

References 5 publications

Treatment satisfaction in patients with erectile dysfunction switching from prostaglandin E1 intracavernosal injection therapy to oral sildenafil citrate

Treatment satisfaction in patients with erectile dysfunction switching from prostaglandin E1 intracavernosal injection therapy to oral sildenafil citrate

High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy

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