Intracavernous Therapy in Impotence after Pelvic Trauma

Intracavernous injection of vasoactive substances are used in the treatment and investigation of impotence. We studied the effects induced by some pharmacological agents on strips of human erectile tissue. Specimens of corpus cavernosum were obtained from 16 men undergoing cystectomy or penectomy for bladder or penile malignancy. Strip preparations were mounted in thermostically controlled baths containing Krebs solution. Pharmacologic effects were monitored by means of an isotonic transducer. Papaverine was shown to be the substance able to cause the biggest relaxation effect. The authors compared the action of other drugs having a relaxant effect, studied the antagonist effects of epinephrine and dopamine on the pharmacologically relaxed preparations, and stressed that the relaxation of the erectile tissue has a determinant role in the appearance and maintenance of erection.

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Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs

Barbanti

Beneforti

Lapini

et al. 1988

Urol. Res.

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Factors predicting efficacy of phentolamine-papaverine intracorporeal injection for treatment of erectile dysfunction in diabetic male

Bell¹,

Cutter

Hayne

et al. 1992

Urology

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Barbagli

2006

Journal of Urology

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Intracavernous Therapy in Impotence after Pelvic Trauma

Cited by 6 publications

References 4 publications

Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs

Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs

Factors predicting efficacy of phentolamine-papaverine intracorporeal injection for treatment of erectile dysfunction in diabetic male

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