Intracavity biosensor based on the Nd:YAG waveguide laser: tumor cells and dextrose solutions

Li, Guanhua; Li, Huiyuan; Gong, Rumei; Tan, Yang; Aldana, Javier R. Vázquez de; Sun, Yun; Chen, Feng

doi:10.1364/prj.5.000728

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…The results achieved in this work are promising for the fabrication of more complex passive and active photonic microstructures based on anisotropic crystals, such as a Mach-Zehnder interferometer with envisioned applications in active optical sensing [49], waveguides with multiple Y-branches, or 3D bulk / surface structures. The active Y-splitting waveguides with a single transverse mode output are potentially interesting for dual-comb high repetition rate (GHz-range) mode-locked oscillators with application in high-resolution on-chip spectroscopy.…”

Section: Discussionmentioning

confidence: 92%

Ultrafast Laser Inscription and ∼2 μm Laser Operation of Y-Branch Splitters in Monoclinic Crystals

Kifle

Loiko

Romero

et al. 2020

J. Lightwave Technol.

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We report on the first active surface Y-branch waveguide in the ∼2 µm spectral range. Depressed-cladding rectangular-cross-section surface waveguides with a splitting ratio of 1 × 2 are fabricated by femtosecond direct laser writing in a thulium (Tm 3+ ) doped monoclinic double tungstate crystal. Confocal laser microscopy and µ-Raman spectroscopy reveal well preserved crystallinity of the waveguide core. Under high-brightness laser pumping at 0.8 µm, a simultaneous continuous-wave laser operation in both arms is achieved resulting in a total output power of 0.46 W at ∼1.84 µm with a slope efficiency of 40.6% and a laser threshold of 0.28 W. The laser output is linearly polarized and spatially multimode (TE 12 /TE 22 ) with a power splitting ratio between arms of 52.1/47.9%). The waveguide propagation losses at 1.84 µm are ∼1.6 dB/cm and the loss from the Y-junction is 0.1 dB. The fabricated waveguides represent a route towards advanced photonic micro-structures such as a Mach-Zehnder interferometer for bio-sensing at ∼2 µm.

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Section: Discussionmentioning

confidence: 92%

Ultrafast Laser Inscription and ∼2 μm Laser Operation of Y-Branch Splitters in Monoclinic Crystals

Kifle

Loiko

Romero

et al. 2020

J. Lightwave Technol.

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“…In this approach, a large number of parallel low-index laser damage tracks are produced to construct the waveguide cladding, leaving unaffected the waveguide core where the light propagates through. Efficient devices have been fabricated in crystals based on this approach such as waveguide lasers [13], frequency converters [14], beam shapers/splitters [15] or biosensors [16], that operate in the continuous wave or long-pulse regimes. To the authors knowledge, the use of cladding waveguides for ultrafast applications has not been explored yet.…”

Section: Introductionmentioning

confidence: 99%

Ultrashort pulse propagation through depressed-cladding channel waveguides in YAG crystal: Spatio-temporal characterization

Morales-Vidal

Sola

Castillo

et al. 2020

Optics & Laser Technology

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Inscription of optical waveguides by direct femtosecond laser irradiation has become a very versatile tool for the development of integrated photonic devices, such as waveguide lasers, frequency converters or photonic lanterns, among many others. The potential application of such devices for the control and manipulation of ultrashort pulses requires the precise knowledge of the temporal distortions that may be induced in the pulse propagation. Currently, research in this topic is scarce, and to our knowledge there is no previous experimental study on the spatio-temporal characterization at the output of waveguides inscribed inside crystals. Here, we have firstly fabricated depressedcladding waveguides with different modal behavior in YAG crystal by direct femtosecond laser irradiation. Then, we implemented an experimental method based on the fiber coupler assisted spectral interferometry technique, that allows obtaining: 1) the temporal dispersion of a pulse at the output of an inscribed waveguide and, 2) full spatio-spectral and spatio-temporal characterization of the output of single-mode and multi-mode waveguides. Our results suggest that the main contribution to the pulse dispersion is due to the material dispersion. Moreover, we found that multimodal waveguides may induce an appreciable inhomogeneity in the temporal features of the pulses that needs to be taken into account in the design of complex devices.

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Two‐Dimensional Light Scattering Anisotropy Cytometry for Label‐Free Classification of Ovarian Cancer Cells via Machine Learning

Yuan

Wang

et al. 2019

Cytometry Pt A

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We develop a single‐mode fiber‐based cytometer for the obtaining of two‐dimensional (2D) light scattering patterns from static single cells. Anisotropy of the 2D light scattering patterns of single cells from ovarian cancer and normal cell lines is investigated by histograms of oriented gradients (HOG) method. By analyzing the HOG descriptors with support vector machine, an accuracy rate of 92.84% is achieved for the automatic classification of these two kinds of label‐free cells. The 2D light scattering anisotropy cytometry combined with machine learning may provide a label‐free, automatic method for screening of ovarian cancer cells, and other types of cells. © 2019 International Society for Advancement of Cytometry

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Intracavity biosensor based on the Nd:YAG waveguide laser: tumor cells and dextrose solutions

Cited by 6 publications

References 19 publications

Ultrafast Laser Inscription and ∼2 μm Laser Operation of Y-Branch Splitters in Monoclinic Crystals

Ultrafast Laser Inscription and ∼2 μm Laser Operation of Y-Branch Splitters in Monoclinic Crystals

Ultrashort pulse propagation through depressed-cladding channel waveguides in YAG crystal: Spatio-temporal characterization

Two‐Dimensional Light Scattering Anisotropy Cytometry for Label‐Free Classification of Ovarian Cancer Cells via Machine Learning

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