Contemporary Topics in Immunobiology 1977
DOI: 10.1007/978-1-4684-3051-6_3
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Intracellular and Systemic Regulation of Biologically Distinguishable Endogenous Type C RNA Viruses of Mouse Cells

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Cited by 2 publications
(5 citation statements)
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“…Although all inbred mice (Mus musculus) apparently contain endogenous retroviral genomes (15,16) that are potentially infectious (17), strains vary markedly in their viral expression in vivo and in vitro (18)(19)(20)(21). Some retroviral genomes, such as the ecotropic murine leukemia virus (MuLV) genome of the AKR mouse (22,23), can be readily activated from AKR cells by the halogenated pyrimidines 5-iododeoxyuridine (IdUrd) and 5- Chemicals.…”
Section: Akr Mulv or Rauscher Mulv Is Infectious With Or Withoutmentioning
confidence: 99%
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“…Although all inbred mice (Mus musculus) apparently contain endogenous retroviral genomes (15,16) that are potentially infectious (17), strains vary markedly in their viral expression in vivo and in vitro (18)(19)(20)(21). Some retroviral genomes, such as the ecotropic murine leukemia virus (MuLV) genome of the AKR mouse (22,23), can be readily activated from AKR cells by the halogenated pyrimidines 5-iododeoxyuridine (IdUrd) and 5- Chemicals.…”
Section: Akr Mulv or Rauscher Mulv Is Infectious With Or Withoutmentioning
confidence: 99%
“…The demonstration of complete retroviral expression from the DNA of normal cells would show directly that the cell DNA is potentially infectious. In addition, an infectivity assay for an endogenous viral genome would be useful in attempting to elucidate the cellular and viral mechanisms that restrict the expression of the viral genome in the endogenous state and permit its expression in the productively infected state.Although all inbred mice (Mus musculus) apparently contain endogenous retroviral genomes (15, 16) that are potentially infectious (17), strains vary markedly in their viral expression in vivo and in vitro (18)(19)(20)(21) Chemicals. IdUrd was purchased from Sigma and it was stored at 1 mg/ml in sterile phosphate-buffered saline at -20°C.…”
mentioning
confidence: 99%
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“…Since BALBic cells contain genetic information for at least three viruses distinguishable by their host range (Aaronson and Stephenson, 1977), infectivity experiments were performed in a wide spectrum of animal cell cultures to determine which endogenous virus was activated within MOPC-315 murine myeloma cells. To assess the MOPC-315 virus capacity to replicate in various mammalian species, cell-free MOPC-315 viral particles were inoculated onto DEAE-dextran pretreated cell cultures of representative species, as detailed in Table I.…”
Section: Host Range Of the Mopc-315 Virusmentioning
confidence: 99%
“…Whereas thorough biological investigation of the endogenous murine type-C viruses has led in several cases to the establishment of their etiological involvement in neoplasia (Aaronson and Stephenson, 1977), attention has, in contrast, been focused on only a few of the myeloma viruses. The present paper describes the biological features of an additional member of the group of myeloma viruses and accordingly, discusses their possible role in the malignant transformation of plasma cells.…”
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confidence: 99%