2024
DOI: 10.1128/jb.00208-24
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Intracellular ATP concentration is a key regulator of bacterial cell fate

Bo Li,
Xiao Chen,
Jin-Yu Yang
et al.

Abstract: ATP, most widely known as the primary energy source for numerous cellular processes, also exhibits the characteristics of a biological hydrotrope. The viable but nonculturable (VBNC) and persister states are two prevalent dormant phenotypes employed by bacteria to survive challenging environments, both of which are associated with low metabolic activity. Here, we investigate the intracellular ATP concentration of individual VBNC and persister cells using a sensitive ATP biosensor QUEEN-7μ and reveal that both … Show more

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