Intracellular calcium as an index of neurotoxic damage

Bondy, Stephen C.; Komulainen, Hannu

doi:10.1016/0300-483x(88)90171-0

Cited by 31 publications

(16 citation statements)

References 22 publications

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“…All of these agents are also capable of increasing intracellular levels of calcium ions in isolated systems (78,79). Several neurotoxic chemicals have been shown to elevate cerebral rates of ROS production in experimental animals.…”

Section: Evidence For Oxidative and Excitotoxic Events Associated Witmentioning

confidence: 99%

The Relation of Oxidative Stress and Hyperexcitation to Neurological Disease

Bondy¹

1995

Experimental Biology and Medicine

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The expression of a considerable range of neurological diseases is thought to involve two pathological states, namely, the production of excessive amounts of reactive oxygen species and neuronal hyperactivity. These events may represent an outcome of general vulnerable features of nervous tissue. Since they are associated with many unrelated diseases, the phenomena may be considered the final common pathways of a range of metabolic defects. Superimposed on these general signs of cellular impairment are the more specific features of each disorder. This review describes some of the evidence for the presence of hyperactivity and oxidative stress in various neurological disorders. Mechanisms whereby the states may interact and modulate each other are discussed. The manner in which such understanding has implications for the development of novel therapeutic approaches is also described.

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Section: Evidence For Oxidative and Excitotoxic Events Associated Witmentioning

confidence: 99%

The Relation of Oxidative Stress and Hyperexcitation to Neurological Disease

Bondy¹

1995

Experimental Biology and Medicine

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“…Cytosolic calcium concentration in synaptosomes from female rats 3 months old (Group I) and 14 months old (Group I1 and Group 111). 1990) and chlorodecone (Bondy & komulainen 1988). technical xylene prenatally on days 7-20 6 hr per day.…”

Section: Discussionmentioning

confidence: 97%

The Effect of Ageing and in vitro Exposure to Xylene and KC1 on [Ca²⁺]_i in Synaptosomes from Rats Exposed Prenatally to Xylene

Edelfors

Hass²,

Ravn-Jonsen

et al. 1996

Pharmacology & Toxicology

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Female rats (Mol: WIST) were exposed prenatally to 500 p.p.m. of technical xylene on days 7-20. At the age of fourteen months the rats were sacrificed and the synaptosomal fraction prepared for in vitro studies. The cytosolic calcium concentration was measured using the FURA-2 technique. The cytosolic calcium was increased in synaptosomes from old rats compared to those from rats at the age of three months, but no effect of prenatal exposure was seen. When synaptosomes were incubated with xylene, potassium or both, the cytosolic calcium concentration was changed identically in all groups of rats. When synaptosomes were incubated simultaneously to xylene and potassium a dramatical leakage of FURA-2 was observed. The mechanisms behind the membrane leakage are discussed.

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“…However, even when synaptosomal ATP levels are at 50% of their normal level, [Ca2+]. is not significantly elevated (Bondy and Komulainen, 1988). Calcium-removing processes may thus have a priority for available energy when ATP levels are depressed.…”

Section: Discussionmentioning

confidence: 99%