Intracellular co-delivery of Sr ion and phenamil drug through mesoporous bioglass nanocarriers synergizes BMP signaling and tissue mineralization

Lee, Jung Hwan; Mandakhbayar, Nandin; El‐Fiqi, Ahmed; Kim, Hae‐Won

doi:10.1016/j.actbio.2017.07.021

Cited by 84 publications

(81 citation statements)

References 74 publications

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“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

Section: Resultsmentioning

confidence: 99%

“…Studying the genes expressed by the cells placed in contact with glasses is essential to evaluate their ability to promote and to sustain cell differentiation, two steps necessary for tissue repair. Consequently, if it is possible to prove that sol–gel derived BGs are able, by dissolving their ions in the media, to sustain cell growth and proliferation, the only studies reporting a gene expression analysis allow to conclude on the actual effectiveness of BGs in triggering cells differentiation …”

Section: Discussionmentioning

confidence: 99%

“…Three articles have studied the effects of increasing strontium (Sr) in a sol–gel glass system: one on PDLCs, one on DPSCs, and one on BMSCs . Sr (6 or 10 mol%) promoted cells’ viability and proliferation in a time‐dependent manner (14 days).…”

Section: Pure Bgsmentioning

confidence: 99%

“…In addition, osteogenesis/cementogenesis‐related gene expression was enhanced. In addition, Lee et al loaded the Sr‐doped glass with phenamil. A synergism between Sr and Phenamil was found in activating a (tribbles homolog 3) Trb3‐dependent bone morphogenetic protein (BMP) signaling pathway.…”

Section: Pure Bgsmentioning

confidence: 99%

“…A synergism between Sr and Phenamil was found in activating a (tribbles homolog 3) Trb3‐dependent bone morphogenetic protein (BMP) signaling pathway. Two articles have explored the possibility to use Sr‐BG in vivo . It demonstrated that Sr‐MBG scaffolds led to greater new bone formation in Wistar rats and SD mice with periodontal defects.…”

Section: Pure Bgsmentioning

confidence: 99%

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Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

et al. 2018

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Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement. The research ranged 5 years' window time (from January, 01, 2012, to August, 31, 2017) and the relevant studies were identified based on the inclusion/exclusion criteria. A total of 45 articles were selected from 244 initial returns, plus seven further articles coming from other sources were selected for the same purpose. From this systematic study, it is revealed that only 13 of the 52 articles have proved both the ability of BGs to differentiate dental cells at genetic level and their ability of triggering cell-mediated mineralization, but only six of them showed, along with cells, the antibacterial properties of the glasses. This review shows that sol-gel BGs are not toxic, can sustain cell proliferation and differentiation at a genetic level, and can keep the bacterial population under control. Moreover, a standard methodology and an ideal material are suggested. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018.

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“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%