Intracellular dark-field imaging of ATP and photothermal therapy using a colorimetric assay based on gold nanoparticle aggregation via tetrazine/trans-cyclooctene cycloaddition

Liu, Fei; Guo, Yingshu; Hu, Yinhua; Zhang, Xiaoru; Zheng, Xiaoting

doi:10.1007/s00216-019-01966-0

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…If drugs or cells are simply mixed into the sol and then injected into the target tissue, a static gel will be formed in situ . Because of this unique temperature sensitivity, thermosensitive nanomaterials based on thermosensitive polymers have been widely used in drug carriers ( Guo et al, 2017b ; Guo et al, 2021a ; Guo et al, 2021b ; Guo et al, 2021d ), tissue engineering, and cell culture, sensing analysis ( Guo et al, 2016a ; Guo et al, 2016b ; Liu F. et al, 2019 ; Guo et al, 2020b ) ( Shi et al, 2016 ; Shi et al, 2019 ).…”

Section: Applications In Biomedical Fieldmentioning

confidence: 99%

Nanomaterials based on thermosensitive polymer in biomedical field

et al. 2022

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The progress of nanotechnology enables us to make use of the special properties of materials on the nanoscale and open up many new fields of biomedical research. Among them, thermosensitive nanomaterials stand out in many biomedical fields because of their “intelligent” behavior in response to temperature changes. However, this article mainly reviews the research progress of thermosensitive nanomaterials, which are popular in biomedical applications in recent years. Here, we simply classify the thermally responsive nanomaterials according to the types of polymers, focusing on the mechanisms of action and their advantages and potential. Finally, we deeply investigate the applications of thermosensitive nanomaterials in drug delivery, tissue engineering, sensing analysis, cell culture, 3D printing, and other fields and probe the current challenges and future development prospects of thermosensitive nanomaterials.

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Section: Applications In Biomedical Fieldmentioning

confidence: 99%

Nanomaterials based on thermosensitive polymer in biomedical field

et al. 2022

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Section: Dfm-assisted Analysismentioning

confidence: 99%

“…In analyzing the activity of the radiation nanomedicine, the binding and internalization were measured by DFM and fluorescence imaging . In addition to the Raman analysis assisted by DFM, DFM has been used in a variety of fields, such as photoacoustic imaging, photothermal therapy, and hot electron response imaging (Figure D) …”

Section: Dfm-assisted Analysismentioning

confidence: 99%

“…167 In analyzing the activity of the radiation nanomedicine, the binding and internalization were measured by DFM and fluorescence imaging. 168 In addition to the Raman analysis assisted by DFM, DFM has been used in a variety of fields, such as photoacoustic imaging, 169 photothermal therapy, 170 and hot electron response imaging (Figure 12D). Before the flow cytometry method for measuring the cellular uptake of gold nanoparticles, DFM was first used to confirm the cell uptake activity, and the nuclear localization signal peptide-modified gold nanoparticles exhibited a higher uptake efficiency.…”

Section: ■ Technology Combinationmentioning

confidence: 99%

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Dark-Field Microscopy: Recent Advances in Accurate Analysis and Emerging Applications

2021

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“…Recently, various analytical assays such as peptides, aptamers, − fluorescent probes, − dark-field imaging, and luminescent assay have been developed for ATP determination both in vitro and in vivo, owing to its biological significance. Although each strategy has its own advantages, there are still some major problems to be solved.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Single-Layered Graphene Quantum Dots Used for Diagnosis of Mitochondrial Malfunction-Related Diseases

Jiang

Liu

Que

et al. 2019

ACS Biomater. Sci. Eng.

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Mitochondria are critical organelles in eukaryotes that efficiently generate adenosine 5′-triphosphate (ATP) for various biological activities, and any defect in the process of ATP synthesis may lead to mitochondrial dysfunction and directly link to a variety of medical disorders. Monitoring the ATP variations in cells is key for innovative early diagnosis of mitochondrial diseases. Herein, multifunctional single-layered graphene quantum dots (s-GQDs) with bright green emission were constructed, which exhibit strong binding affinity for ATP and good mitochondria targeting ability. Using the proposed s-GQDs, we successfully discriminated the primary smooth muscle cells isolated from the transgenic mouse (heterozygote sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA) 2 C674S knock-in mouse) with mitochondrial disorders or their littermate controls, indicating s-GQDs as promising probes for the study of cell metabolism and mitochondrial malfunction-related diseases, and targeting endoplasmic reticulum stress is an effective way to modulate metabolic pathways relevant to SERCA 2 inactivity mitochondrial dysfunction.

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Intracellular dark-field imaging of ATP and photothermal therapy using a colorimetric assay based on gold nanoparticle aggregation via tetrazine/trans-cyclooctene cycloaddition

Cited by 13 publications

References 33 publications

Nanomaterials based on thermosensitive polymer in biomedical field

Nanomaterials based on thermosensitive polymer in biomedical field

Dark-Field Microscopy: Recent Advances in Accurate Analysis and Emerging Applications

Multifunctional Single-Layered Graphene Quantum Dots Used for Diagnosis of Mitochondrial Malfunction-Related Diseases

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