2017
DOI: 10.2147/ijn.s142060
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Intracellular disposition of chitosan nanoparticles in macrophages: intracellular uptake, exocytosis, and intercellular transport

Abstract: Biodegradable nanomaterials have been widely used in numerous medical fields. To further improve such efforts, this study focused on the intracellular disposition of chitosan nanoparticles (CsNPs) in macrophages, a primary cell of the mononuclear phagocyte system (MPS). Such interactions with the MPS determine the nanoparticle retention time in the body and consequently play a significant role in their own clinical safety. In this study, various dye-labeled CsNPs (about 250 nm) were prepared, and a murine macr… Show more

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Cited by 84 publications
(41 citation statements)
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“…Contrarily, eukaryotic cells such as macrophages, uptake CSnp intracellularly, mediated by endocytosis, and degrade them via lysosomal and multivesicular body pathways [39]. Macrophages are one of the major players in the host defense mechanisms against infection and their presence in human inflammatory periapical lesions has been long recognized in different phases of the disease [40].…”
Section: Discussionmentioning
confidence: 99%
“…Contrarily, eukaryotic cells such as macrophages, uptake CSnp intracellularly, mediated by endocytosis, and degrade them via lysosomal and multivesicular body pathways [39]. Macrophages are one of the major players in the host defense mechanisms against infection and their presence in human inflammatory periapical lesions has been long recognized in different phases of the disease [40].…”
Section: Discussionmentioning
confidence: 99%
“…The model allows binding to Kupffer cells and extrahepatic clearance of nanoparticles to be characterized using dynamic magnetic resonance imaging (MRI) as seen in Figure 5 (106). The constants K in and K out describe the kinetics of nanoparticles associated with and dissociated from the macrophage, and the constant K e describes the elimination of nanoparticles from the blood compartment by the extrahepatic RES (97).…”
Section: Pharmacokinetic Modelsmentioning
confidence: 99%
“…Nevertheless, nanoparticles with a diameter much above 100 nm would not be eligible to be taken-up by LDL receptors, but rather more prone to be phagocytized by macrophages. Indeed, it is established that larger particles are trapped by macrophage scavenger receptors ( 37 39 ). The effects of LDE-paclitaxel on the atherosclerotic lesions for the two preparations, small and large nanoparticles, were not much different from those found for LDE-paclitaxel documented in our previous study ( 11 ).…”
Section: Discussionmentioning
confidence: 99%