Intracellular Imaging of Glutathione with MnO2 Nanosheet@Ru(bpy)32+–UiO-66 Nanocomposites

Zhu, Suwen; Wang, Sicheng; Xia, Mengmeng; Wang, Baojuan; Huang, Yu; Zhang, Dexing; Zhang, Xiaojun; Wang, Guangfeng

doi:10.1021/acsami.9b11025

Cited by 52 publications

(24 citation statements)

References 56 publications

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“…Besides GSH, Hcy and Cys also restore fluorescence because of their thiol group. However, according to previous reports, the contents of GSH in cells are 1000 times higher than those of Hcy and Cys. − Therefore, as shown in Figure S5, when the concentrations of Hcy and Cys are lower than 1000 times that of GSH, low concentrations of interfering substances do not affect the detection process, indicating that the interfere of Cys and Hcy could be neglected during the detection procedure.…”

Section: Resultssupporting

confidence: 59%

Biodegradable Fluorescent SiO₂@MnO₂-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Zhang

Wang

Meng

et al. 2021

ACS Sustainable Chem. Eng.

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Herein, we report an activatable multifunctional nanocomposite (denoted as FSMP) for glutathione (GSH) sensing and synergistic theragnostics to cancer cells. This novel core–shell architecture orderly consists of a fluorescein isothiocyanate-doped SiO2 core, a methylene blue (MB)-encapsulated porous MnO2 shell, and poly(ethylene glycol) for shielding the MB from premature leaking. The fluorescence of the core will be effectively quenched by MnO2 due to the Förster resonance energy transfer, and the quenched signals could be recovered in the presence of GSH, as a result of the reduction of MnO2 to Mn2+. The constructed GSH sensing nanoplatform shows stable response to GSH in a linear range of 10–300 μM with the limit of detection of 2.1 μM. Besides acting as a fluorescence quencher and a GSH recognizer, MnO2 also serves as a sequence self-reinforcing Fenton nanoagent based on the GSH sensing to form Mn2+, which exerts the activity to generate •OH from H2O2. Further, combined with the MB-mediated photodynamic 1O2 generation, the multifunctional nanocomposite jointly produces an enhanced therapeutic effect. In addition, FSMP will be degraded within 48 h, thus significantly reducing the potential nanotoxicity. We believe the MnO2-nanomaterial-based sequence strategy could potentially improve biochemical analysis and cancer cell theragnostics applications.

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Section: Resultssupporting

confidence: 59%

Biodegradable Fluorescent SiO₂@MnO₂-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Zhang

Wang

Meng

et al. 2021

ACS Sustainable Chem. Eng.

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“…Ru(bpy) 3 2+ is encapsulated stably in MOF pores, which makes the sensor have the advantages of high sensitivity, low detection limit, wide detection range, fast response, strong stability, and reusability. Zhu et al encapsulated the cationic complex Ru(bpy) 3 2+ in the framework of UiO-66 coated with manganese dioxide nanosheets (MnO 2 NSs). The existence of MnO 2 NSs inhibited the release of Ru(bpy) 3 2+ , thus quenching its fluorescence.…”

Section: Encapsulation Of Different Luminescent Guests In the Mofsmentioning

confidence: 99%

Section: Encapsulation Of Different Luminescent Guests In the Mofsmentioning

confidence: 99%

Encapsulation of Luminescent Guests to Construct Luminescent Metal–Organic Frameworks for Chemical Sensing

et al. 2021

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Metal−organic frameworks (MOFs), which are a class of coordination polymers constructed by metal ions or clusters with organic ligands, have emerged as exciting inorganic−organic hybrid materials with the superiorities of inherent crystallinity, adjustable pore size, clear structure, and high degree of functionalization. The MOFs have attracted much attention to develop good luminescent functional materials due to their inherent luminescent centers of both inorganic and organic photonic units. Furthermore, the pores within MOFs can also be used to encapsulate a large number of luminescent guest species, which provides a broader luminescent property for MOF materials. MOFs possess the incomparable multifunctional advantages of inorganic and organic luminescent materials. A large number of luminescent MOFs (LMOFs) have been synthesized for applications in sensing, white-light-emitting diodes (LED), photocatalysis, biomedicine, etc. This paper reviews the encapsulation of various luminescent guests such as lanthanide ions, dyes, quantum dots, and luminescent complexes in metal−organic frameworks to construct luminous sensors with single-or double-emission centers, as well as the research progress of these sensors in chemical sensing. Finally, the challenges in these fields were outlined and the prospects for future development were put forward.

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“…Thus, the fluorescence intensity of fluorescence nanoparticles could be recovered. Based on the above mechanism, fluorescence nanoparticles and a MnO 2 binary system − such as carbon dots (CDs) and MnO 2 nanosheets, − upconversion fluorescence nanoparticles and MnO 2 nanosheets, , and gold nanoclusters and MnO 2 nanosheetswere proposed for fluorescence signal ″off–on″ detection of GSH, AA, or H 2 O 2 .…”

Section: Introductionmentioning

confidence: 99%

CDs–MnO₂–TPPS Ternary System for Ratiometric Fluorescence Detection of Ascorbic Acid and Alkaline Phosphatase

2021

ACS Omega

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Manganese dioxide (MnO 2 ) nanosheet-based fluorescence sensors often use oxidase-like activity or wide absorption spectrum for detection of antioxidants. In those strategies, MnO 2 nanosheets were reduced to Mn 2+ by antioxidants. However, few strategies emphasize the role of Mn 2+ obtained from MnO 2 reduction in the design of the fluorescence sensor. Herein, we expanded the application of a MnO 2 nanosheet-based fluorescence sensor by involving Mn 2+ in the detection process using ascorbic acid (AA) as a model target. In this strategy, carbon dots (CDs), MnO 2 nanosheets, and tetraphenylporphyrin tetrasulfonic acid (TPPS) comprise a ternary system for ratiometric fluorescence detection of AA. Initially, CDs were quenched by MnO 2 nanosheets based on the inner filter effect, while TPPS maintained its fluorescence intensity. After the addition of AA, MnO 2 nanosheets were reduced to Mn 2+ so that the fluorescence intensity of CDs was recovered and TTPS was quenched by coordination with Mn 2+ . Overall, AA triggered an emission intensity increase at 440 nm for CDs and a decrease at 640 nm for TPPS. The ratio intensity of CDs to TPPS ( F 440 / F 640 ) showed a good linear relationship from 0.5 to 40 μM, with a low detection limit of 0.13 μM for AA detection. By means of the alkaline phosphatase (ALP)-triggered generation of AA, this strategy can be applied for the detection of ALP in the range of 0.1–100 mU/mL, with a detection limit of 0.04 mU/mL. Furthermore, this sensor was applied to detect AA and ALP in real, complex samples with ideal recovery. This novel platform extended the application of MnO 2 nanosheet-based fluorescence sensors.

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Intracellular Imaging of Glutathione with MnO₂ Nanosheet@Ru(bpy)₃²⁺–UiO-66 Nanocomposites

Cited by 52 publications

References 56 publications

Biodegradable Fluorescent SiO₂@MnO₂-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Biodegradable Fluorescent SiO₂@MnO₂-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Encapsulation of Luminescent Guests to Construct Luminescent Metal–Organic Frameworks for Chemical Sensing

CDs–MnO₂–TPPS Ternary System for Ratiometric Fluorescence Detection of Ascorbic Acid and Alkaline Phosphatase

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Intracellular Imaging of Glutathione with MnO2 Nanosheet@Ru(bpy)32+–UiO-66 Nanocomposites

Cited by 52 publications

References 56 publications

Biodegradable Fluorescent SiO2@MnO2-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Biodegradable Fluorescent SiO2@MnO2-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Encapsulation of Luminescent Guests to Construct Luminescent Metal–Organic Frameworks for Chemical Sensing

CDs–MnO2–TPPS Ternary System for Ratiometric Fluorescence Detection of Ascorbic Acid and Alkaline Phosphatase

Contact Info

Product

Resources

About

Intracellular Imaging of Glutathione with MnO₂ Nanosheet@Ru(bpy)₃²⁺–UiO-66 Nanocomposites

Biodegradable Fluorescent SiO₂@MnO₂-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

Biodegradable Fluorescent SiO₂@MnO₂-Based Sequence Strategy for Glutathione Sensing in a Biological System and Synergistic Theragnostics to Cancer Cells

CDs–MnO₂–TPPS Ternary System for Ratiometric Fluorescence Detection of Ascorbic Acid and Alkaline Phosphatase