Intracellular ionized calcium and increasing doses of lithium chloride therapy in healthy Sprague-Dawley rats

Adegboyega, Patrick A.; Okorodudu, Anthony O.

doi:10.1016/0091-3057(94)90269-0

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…In LG, it was noted, however, that the mean plasma concentrations of ionized calcium was higher compared with the CG (Figure 2). This finding is in agreement with several literature reports and it may be explained by the fact that the ionized calcium is more sensitive than the total calcium for detection of hypercalcemia in patients treated with Li (32,33).…”

Section: Discussionsupporting

confidence: 82%

Evaluation of parathyroid function and mineral metabolism in psychiatric patients using lithium salts

Oliveira

Neto

Aguiar‐Oliveira

et al. 2014

Arq Bras Endocrinol Metab

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Objective: To evaluate parathyroid function and mineral metabolism in psychiatric patients users of lithium salts. Materials and methods: We measured the serum levels of calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, albumin, parathyroid hormone (PTH), urea, creatinine, 25-hydroxy-vitamin D and lithium of 35 patients diagnosed with bipolar disorder in use of lithium carbonate (LC) for at least one year (Lithium Group -LG) and 35 healthy subjects (Control Group -CG). Results: The LG and CG were matched by sex and age. There was only statistic difference in relation to the levels of PTH and ionized calcium, with p < 0.004 and p < 0.03, respectively. Secondary form of hyperparathyroidism (HPT) was found in eight (22.8%) LG patients and in none of the CG. There was no correlation between lithemia, usage time and dosage of LC. Conclusion: Our data demonstrate that lithium may create an imbalance in the parathyroid axis, characterized by elevated levels of PTH. Arq Bras Endocrinol Metab. 2014;58(6):619-24Keywords Lithium; parathyroid; mineral metabolism; hyperparathyroidism RESUMO Objetivo: Avaliar a função paratireoidiana e o metabolismo mineral em pacientes psiquiátricos usuários de sais de lítio. Materiais e métodos: Foram avaliados os níveis séricos de cálcio total, cálcio iônico, fósforo inorgânico, fosfatase alcalina, albumina, paratormônio (PTH), ureia, creatinina, 25-hidroxivitamina D e lítio de 35 pacientes diagnosticados com transtorno afetivo bipolar usuários de carbonato de lítio (CL) há pelo menos um ano (Grupo Lítio -GL) e 35 indivíduos saudáveis (Grupo Controle -GC). Resultados: O GL e o GC foram pareados por sexo e idade. Somente se observou diferença estatística em relação aos níveis de PTH e cálcio iônico, com p < 0,004 e p < 0,03, respectivamente. Hiperparatireoidismo secundário foi encontrado em oito (22.8%) pacientes do GL e em nenhum do GC. No GL, não houve correlação entre litemia, tempo de uso e posologia do CL. Conclusão: Nossos dados demonstram que o lítio pode suscitar um desequilíbrio no eixo paratireoideano, caracterizado por níveis elevados de PTH. Arq Bras Endocrinol Metab. 2014;58(6):619-24 Descritores Lítio; paratireoide; metabolismo mineral; hiperparatireoidismo

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Section: Discussionsupporting

confidence: 82%