Intracellular light chain crystals in myeloma

Staubach, Zane G.; Rodman, J. Blake

doi:10.1182/blood-2017-04-779207

Blood

2017

DOI: 10.1182/blood-2017-04-779207

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Intracellular light chain crystals in myeloma

Zane G. Staubach

J. Blake Rodman

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2017

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White rodlike crystals in multiple myeloma cells

Zhang¹,

Ma²,

He³

2017

Hematol Med Oncol

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Objective: Several intracytoplasmic morphological changes in the plasma cells of multiple myeloma have been described previously, especially the Auer rod-like inclusions, but no studies focusing on white rodlike crystal inclusions have been reported to date. In this paper, we intend to report a rare case of inclusions in multiple myeloma.Methods: Bone marrow aspiration from the right superior iliac spine was examined. Cells were stained with "Wright-Giemsa" method and also analyzed by flow cytometry, immunohistochemical staining and fluorescence in situ hybridization(FISH). Bone scan, complete blood count, serum chemistry and coagulation tests were also examined.Results: Bone marrow aspirate from the right superior iliac spine at the time of myeloma diagnosis showed about 26.5% of all nucleated cells being plasma cells, of which many had white rodlike crystal inclusions. Repeat bone marrow biopsy later showed persistence of these morphological findings. All of Flow cytometry, immunohistochemistry and FISH examination support the diagnosis of multiple myeloma. Conclusion:This is the first time to report a multiple myeloma case with such white rodlike crystal inclusions. It is a rare and unique case. Due to its rarity, it remains unknown whether this morphological finding confers any prognostic implication.

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White rodlike crystals in multiple myeloma cells

Zhang¹,

Ma²,

He³

2017

Hematol Med Oncol

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Intracellular light chain crystals in myeloma

Cited by 1 publication

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White rodlike crystals in multiple myeloma cells

White rodlike crystals in multiple myeloma cells

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