Intracellular RNA and nuclear DNA-dual-targeted tumor therapy via upconversion nanoplatforms with UCL/MR dual-mode bioimaging

Teng, Bo; Ding, Binbin; Shao, Shuai; Wang, Zhanfeng; Tong, Weifang; Wang, Sanchun; Cheng, Ziyong; Lin, Jun; Ma, Ping’an

doi:10.1016/j.cej.2020.126606

Cited by 16 publications

(13 citation statements)

References 44 publications

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“…Although these recent promising progresses of bioenzyme-based nanomedicines in the field of cancer therapy Mesoporous silica Ribonuclease A Catalyze RNA degradation [37] Large-pore mesoporous silica Ribonuclease A Degrade mRNA and tRNA [38] Polymer-based nanoparticles Ribonuclease A Degrade cellular RNA [39] Hollow organosilica Glucose oxidase Consume glucose [40] Mesoporous polydopamine Glucose oxidase Consume glucose [41] Liposomes Glucose oxidase Consume glucose [42] Porous silica nanoparticles Hyaluronidase Decompose HA-DOX to produce toxic dissociative DOX [43] Micelles Collagenase Digest collagen fibers in tumor ECM [45] Nanogels Collagenase Digest tumor ECM [46] Heavy-chain ferritin nanocages Collagenase Degrade the collagen in tumor ECM [47] PCL-PEG nanoparticles Collagenase IV Degrade the collagen component of ECM [48] Chitosan nanoparticles Bromelain Digest tumor ECM [49] Hierarchical nanoparticles Hyaluronidase Degrade hyaluronic acid in tumor ECM [51] Micelles Hyaluronidase Degrade hyaluronic acid in tumor ECM [52] PTT Ultrasmall platinum nanoparticles Glucose oxidase Catalyze glucose to produce H 2 O 2 and D-glucono-δ-lactone [58] Semiconducting polymer nanoparticles Bromelain Digest collagen in tumor ECM [59] Gold/mesoporous polydopamine nanoparticles Papain Degrade tumor ECM [60] Liquid metal nanoparticles Glucose oxidase Inhibit ATP and HSP levels [61] Porous hollow Prussian blue nanoparticles…”

Section: Discussionmentioning

confidence: 99%

“…Co-delivery of enzymes and drugs can also achieve enhanced therapeutic efficacy. Ma's group recently developed a single delivery nanosystem to release cis-platinum pro-drugs (DSP) and RNase A for cancer therapy [38]. The nanosystem was synthesized via encapsulating quadrivalent DSP and RNAse A into large-pore mesoporous silica-coated upconversion nanoparticles.…”

Section: Bioenzyme-based Nanomedicines For Chemotherapymentioning

confidence: 99%

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Bioenzyme-based nanomedicines for enhanced cancer therapy

Ding

Zhang

et al. 2022

Nano Convergence

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Bioenzymes that catalyze reactions within living systems show a great promise for cancer therapy, particularly when they are integrated with nanoparticles to improve their accumulation into tumor sites. Nanomedicines can deliver toxic bioenzymes into cancer cells to directly cause their death for cancer treatment. By modulating the tumor microenvironment, such as pH, glucose concentration, hypoxia, redox levels and heat shock protein expression, bioenzyme-based nanomedicines play crucial roles in improving the therapeutic efficacy of treatments. Moreover, bioenzyme-mediated degradation of the major components in tumor extracellular matrix greatly increases the penetration and retention of nanoparticles in deep tumors and infiltration of immune cells into tumor tissues, thus enhancing the efficacies of chemotherapy, phototherapy and immunotherapy. In this review, we summarize the recent progresses of bioenzyme-based nanomedicines for enhanced cancer therapy. The design and working mechanisms of the bioenzyme-based nanomedicines to achieve enhanced chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, radiotherapy and immunotherapy are introduced in detail. At the end of this review, a conclusion and current challenges and perspectives in this field are given.

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Section: Discussionmentioning

confidence: 99%

Section: Bioenzyme-based Nanomedicines For Chemotherapymentioning

confidence: 99%

Bioenzyme-based nanomedicines for enhanced cancer therapy

Ding

Zhang

et al. 2022

Nano Convergence

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“…considerable attention. [379][380][381] With a large anti-Stokes shift, enhanced tissue penetration depth, high photostability, and thermal stability, and improved signal-to-noise ratios, UCL imaging has been a fascinating and promising technique for excellent H 2 S detection.…”

Section: Upconversion Luminescence Imagingmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding

Chang

et al. 2021

Adv Healthcare Materials

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Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state-of-art research on H 2 S-related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S-mediated gas therapy and H 2 S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S-based therapy that facilitate clinical translation to patients are discussed.

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“…Furthermore, upconversion luminescence (UCL) and magnetic resonance (MR) dual-mode bioimaging can be achieved simultaneously. 169 Yu et al carried out a systematic study to compare the in vivo biodistribution, excretion, and biosafety of PEI modied NaYF 4 :Yb,Er (PEI@UCNPs) among three different exposure routes (IV, IP, and IG). 173 A variety of methods, including inductive coupling plasma mass spectrometry (IPC-SM), histology, body weight and biochemical analysis were used to assess the biodistribution, excretion and biosafety of UCNPs, and no obvious toxicity of UCNPs was observed in mice exposed through either of the tested administration routes.…”

Section: Toxic Side-effects Of Upconversion-based Therapymentioning

confidence: 99%

“…Quadrivalent cisplatinum prodrugs, DSP and cytotoxic protein RNase A were loaded into large-pore mesoporous silica-coated b-NaYF 4 :20%Yb,2%Er@b-NaGdF 4 (UCS) nanoparticles to obtain UCSPtR nanocomposites.Once internalized, this nanoplatform can effectively release cytotoxic protein and DSP and thus induce intracellular RNA degradationmediated and nuclear DNA-targeted killings of cancer cells, respectively, to achieve collaborative treatments of chemotherapy and protein therapy. Furthermore, upconversion luminescence (UCL) and magnetic resonance (MR) dual-mode bioimaging can be achieved simultaneously 169.…”

mentioning

confidence: 99%