Intracellular Signaling Mechanisms Involved in Insulin Action

Zorzano, António

doi:10.1016/b978-84-8174-892-5.50002-4

The Metabolic Syndrome at the Beginning of the XXI Century 2005

DOI: 10.1016/b978-84-8174-892-5.50002-4

|View full text |Cite

Intracellular Signaling Mechanisms Involved in Insulin Action

António Zorzano

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 272 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Interventions Targeting Insulin Resistance in Patients with Type 1 Diabetes: A Narrative Review

Herascu,

Avram,

Gaita

et al. 2024

Medicina

View full text Add to dashboard Cite

Background and Objectives: Insulin resistance (IR) is the most important factor involved in the pathogenesis of type 2 diabetes but may also develop in type 1 diabetes (T1DM). Developing IR in patients with T1DM may generate a burden in achieving glycemic targets and may deteriorate the overall prognosis. This review aims to describe the pathogenesis of IR in T1DM, summarize the common associations of IR with other conditions in patients with T1DM, describe the consequences of developing IR in these patients, and present the interventions that target IR in people with T1DM. Results: The occurrence of IR in T1DM is multifactorial; however, it is frequently linked to overweight or obesity and sedentary lifestyle. Besides impairments in glycemic control and increased insulin requirements, the presence of IR is associated with an increased cardiovascular risk in patients with T1DM. Considering that patients with T1DM are insulin-treated, IR may be evaluated only using surrogate biomarkers, the most frequently used being the estimated glucose disposal rate. The most important interventions that are shown to be feasible in improving insulin sensitivity in patients with T1DM are lifestyle optimizations, including nutrition therapy or physical activity and pharmacotherapy with metformin, sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, and thiazolidinediones. Conclusions: Targeting the improvement of IR in patients with T1DM is a key element in achieving optimal glycemic control, as well as improving the overall patient’s prognosis besides glycemic control.

show abstract

Interventions Targeting Insulin Resistance in Patients with Type 1 Diabetes: A Narrative Review

Herascu,

Avram,

Gaita

et al. 2024

Medicina

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Intracellular Signaling Mechanisms Involved in Insulin Action

Cited by 1 publication

References 272 publications

Interventions Targeting Insulin Resistance in Patients with Type 1 Diabetes: A Narrative Review

Interventions Targeting Insulin Resistance in Patients with Type 1 Diabetes: A Narrative Review

Contact Info

Product

Resources

About