Intracellular Thermometry by Using Fluorescent Gold Nanoclusters

Abstract

The "gold standard" for nanothermometry: The application of ultrasmall, near-IR-emitting fluorescent gold nanoclusters (AuNCs) for temperature sensing has been explored. AuNC-based fluorescent nanothermometry features excellent thermal sensitivity and simultaneous temperature sensing and imaging in HeLa cells.

Microwave-assisted synthesis of photoluminescent glutathione-capped Au/Ag nanoclusters: A unique sensor-on-a-nanoparticle for metal ions, anions, and small molecules

“…4(e)). This phenomenon has recently been observed for lipoic acid-capped AuNCs [49]. Moreover, the emission intensity varied slightly between pH 5 and 9 (Fig.…”

Zwitterion functionalized gold nanoclusters for multimodal near infrared fluorescence and photoacoustic imaging

“…[1][2][3][4] Gold nanoclusters (Au NCs) present several features making them appealing for cancer therapy thanks to (i) their high renal clearance 5,6 reducing toxicity risk, (ii) the relatively high tumor retention by passive uptake, 7,8 (iii) the ability to trigger cell death under light illumination 9 or radiosensitization, [10][11][12] and (iv) the detection by multimodal imaging techniques. [13][14][15] In optical imaging, one of the great advantages of Au NCs compared to plasmonic Au nanoparticles (Au NPs) is related to the ability to visualize them by fluorescence in the red-near-infrared (NIR) region (650-800 nm), a spectral window suitable for in vivo studies due to the reduced tissue scattering and low blood absorption. 16,17 In addition, the high electronic number of gold (Z = 79) allows the detection of gold particles by computed X-ray tomography (CT) 5 and by photoacoustic imaging (PAI).…”

Polyethyleneimine-templated copper nanoclusters via ascorbic acid reduction approach as ferric ion sensor

“…Recently, ultra-small fluorescence metal nanoclusters (NCs), consisting of several to hundreds of metal atoms, have attracted great attention due to their unique physical, optical and electrical properties [1][2][3][4][5]. As their dimensions approach the Fermi wavelength of electrons, these noble-metal NCs have size-tunable electronic transitions and exhibit strong luminescence properties [6][7][8][9].…”