Intracerebral Hemorrhage and Outcome After Thrombolysis in Stroke Patients Using Selective Serotonin-Reuptake Inhibitors

Scheitz, Jan F.; Turc, Guillaume; Kujala, Linda; Polymeris, Alexandros; Heldner, Mirjam Rachel; Zonneveld, Thomas P.; Erdur, Hebun; Curtze, Sami; Traenka, Christopher; Brenière, Céline; Wiest, Roland; Rocco, Andrea; Sibolt, Gerli; Gensicke, Henrik; Endres, Matthias; Martinez‐Majander, Nicolas; Béjot, Yannick; Nederkoorn, Paul J.; Oppenheim, Catherine; Arnold, Marcel; Engelter, Stefan T.; Strbian, Daniel; Nolte, Christian H.

doi:10.1161/strokeaha.117.018377

Cited by 25 publications

(24 citation statements)

References 33 publications

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“…In a large collaborative study, the preadmission use of SSRI alone did not increase the risk of spontaneous intracerebral hemorrhage after intravenous thrombolytic therapy for acute ischemic stroke. While there was a significant interaction between the concurrent preadmission use of SSRIs and oral anticoagulants on the occurrence of intracerebral hemorrhage related to thrombolysis[ 53 ], this condition can be seen in PSD patients with recurrent acute ischemic stroke that are treated with SSRIs. Moreover, fluoxetine and fluvoxamine are reported to have potential interactions with warfarin, and inhibit warfarin metabolism by competitively binding plasma protein and interfering with CYP isoenzymes, which are more likely to strengthen the anticoagulant effects of warfarin.…”

Section: Depressive Disorders After Strokementioning

confidence: 99%

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Zhang¹,

Xu²,

Liu³

et al. 2020

WJP

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A spectrum of neuropsychiatric disorders is a common complication from stroke. Neuropsychiatric disorders after stroke have negative effects on functional recovery, increasing the rate of mortality and disability of stroke survivors. Given the vital significance of maintaining physical and mental health in stroke patients, neuropsychiatric issues after stroke have raised concerns by clinicians and researchers. This mini-review focuses on the most common non-cognitive functional neuropsychiatric disorders seen after stroke, including depressive disorders, anxiety disorders, post-traumatic stress disorder, psychosis, and psychotic disorders. For each condition, the clinical performance, epidemiology, identification of the therapeutic implication, and strategies are reviewed and discussed; the main opinions and perspectives presented here are based on the latest controlled studies, meta-analysis, or updated systematic reviews. In the absence of data from controlled studies, consensus recommendations were provided accordingly.

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Section: Depressive Disorders After Strokementioning

confidence: 99%

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Zhang¹,

Xu²,

Liu³

et al. 2020

WJP

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“…To assess the association between SaO and the respective outcome measures we used the following methods: Unadjusted logistic regression. Logistic regression adjusted for confounding by the following potentially outcome‐modifying parameters, as in prior research: age, sex, NIHSS on admission, prior antithrombotic treatment, glucose and eGFR on admission, EVT in addition to IVT, onset‐to‐treatment time, prior dependence, and prior stroke. Missing values in these variables were imputed using 5 multiple imputations according to van Buuren and Groothuis–Oudshoorn …”

Section: Methodsmentioning

confidence: 99%

Intravenous thrombolysis for suspected ischemic stroke with seizure at onset

Polymeris

Curtze

Erdur

et al. 2019

Annals of Neurology

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for the TRISP CollaboratorsObjective: Seizure at onset (SaO) has been considered a relative contraindication for intravenous thrombolysis (IVT) in patients with acute ischemic stroke, although this appraisal is not evidence based. Here, we investigated the prognostic significance of SaO in patients treated with IVT for suspected ischemic stroke. Methods: In this multicenter, IVT-registry-based study we assessed the association between SaO and symptomatic intracranial hemorrhage (sICH, European Cooperative Acute Stroke Study II definition), 3-month mortality, and 3-month functional outcome on the modified Rankin Scale (mRS) using unadjusted and adjusted logistic regression, coarsened exact matching, and inverse probability weighted analyses. Results: Among 10,074 IVT-treated patients, 146 (1.5%) had SaO. SaO patients had significantly higher National Institutes of Health Stroke Scale score and glucose on admission, and more often female sex, prior stroke, and prior functional dependence than non-SaO patients. In unadjusted analysis, they had generally less favorable outcomes. After controlling for confounders in adjusted, matched, and weighted analyses, all associations between SaO and any of the outcomes disappeared, including sICH (odds ratio [OR] unadjusted = 1.53 [95% confidence interval (CI) = 0.74-3.14], OR adjusted = 0.52 [95% CI = 0.13-2.16], OR matched = 0.68 [95% CI = 0.15-3.03], OR weighted = 0.95 [95% CI = 0.39-2.32]), mortality (OR unadjusted = 1.49 [95% CI = 1.00-2.24], OR adjusted = 0.98 [95% CI = 0.5-1.92], OR matched = 1.13 [95% View this article online at wileyonlinelibrary.com.

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“…21 It remains unclear whether the same can be said for PSD or vascular depression; notably, chronic SSRI treatment increases the risk of hemorrhage. 22,23 However, to examine treatment outcomes for vascular depression, it will be necessary to first detect it using imaging, as mentioned earlier.…”

Section: Does Psd/vascular Depression Respond To Antidepressant Treatmentioning

confidence: 99%

Is poststroke depression the same as major depression?

Albert

2018

jpn

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Intracerebral Hemorrhage and Outcome After Thrombolysis in Stroke Patients Using Selective Serotonin-Reuptake Inhibitors

Cited by 25 publications

References 33 publications

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Intravenous thrombolysis for suspected ischemic stroke with seizure at onset

Is poststroke depression the same as major depression?

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