Intracerebral Hemorrhage due to Venous Thrombosis of Developmental Venous Anomaly during Pregnancy

Seki, Morinobu; Shibata, Mamoru; Itoh, Yoshiaki; Suzuki, Noriyuki

doi:10.1016/j.jstrokecerebrovasdis.2015.03.035

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…31 Only a few reports have cited DVA without cavernous malformation as the cause of intracerebral hemorrhage, and these authors suggest hemorrhagic conversion of a thrombosed DVA as an etiology. 1–22 Several authors cite arterialization of the DVA, or an associated arteriovenous malformation (AVM) or AV fistula, which were absent in this case. 4,9 The patient described in the current study had a non-contrast MRI negative for DVA and cavernous malformation three years prior to the event, suggesting that the DVA was not identified because either it was not present (unlikely as these are deemed congenital lesions) or it was present but outside of the resolution of the screening MRI.…”

Section: Resultsmentioning

confidence: 90%

“…When these venous anomalies are identified, they are thought to be associated with a hemorrhagic cavernous malformation or secondary to hemorrhagic conversion of a venous infarction caused by thrombosis of the DVA. 1–22 Koc et al. reported a case of massive intracerebral hemorrhage due to a DVA without an associated cavernous malformation.…”

Section: Introductionmentioning

confidence: 99%

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Developmental venous anomaly presenting as a spontaneous intraparenchymal hematoma without thrombosis

et al. 2016

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Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Developmental venous anomaly presenting as a spontaneous intraparenchymal hematoma without thrombosis

et al. 2016

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“…Cerebral catheter angiography of DVAs classically reveals radiating veins (eg, ‘caput medusae’) emptying into a deep vein or dural sinus. These are seen in the same phase as normal venous drainage 2–4 6–9. Early radiological identification can help in the initiation of appropriate therapy and prevent incorrect surgical management leading to further neurological demise.…”

Section: Discussionmentioning

confidence: 98%

“…DVAs are a common and typically benign finding in up to 2.5% of the population 1 4. Unlike other vascular malformations, the intervening brain parenchyma is normal, suggesting that DVAs are a consequence of abnormal development and not an acquired pathology 1–3.…”

Section: Discussionmentioning

confidence: 99%

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Paediatric presentation of intracranial haemorrhage due to thrombosis of a developmental venous anomaly

Entezami¹,

Boulos

Yamamoto

et al. 2019

BMJ Case Rep

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Developmental venous anomalies (DVAs) are the most commonly encountered cerebral malformations. While generally asymptomatic and discovered as incidental findings, there is a small number that can cause intracranial haemorrhage, usually attributed to associated cavernomas; however, venous thrombosis of the draining vein is a rare cause. A 10-year-old woman presented with seizure episodes. Angiographic evaluation revealed a collection of vessels draining into the superior sagittal sinus via the vein of Trolard, concerning for a DVA. The patient improved clinically with supportive care and antiepileptic treatment. Anatomically, DVAs represent dysplasia of primary capillary beds and smaller cerebral veins, resulting in abnormal venous drainage of the affected parenchyma. Several distinguishing radiological findings can help differentiate a DVA from other pathologies. Early radiological identification can help in the initiation of appropriate therapy and prevent incorrect surgical management leading to further neurological demise.

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Epilepsy and cerebral developmental venous anomalies (DVAs): A systematic review

Meskine

Reise

et al. 2023

Epileptic Disorders

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Objective Cerebral developmental venous anomalies (DVAs) are frequent and rarely symptomatic. When symptomatic, DVAs may present with seizures; however, little is known about the characteristics of DVA‐related epilepsy. In this systematic review, we aim to describe the clinical and paraclinical features of patients with DVA‐related epilepsy. Methods This review was registered on PROSPERO (CRD42021218711). We searched the MEDLINE/PubMed and Scopus databases for case reports/series on patients with DVAs complicated by seizures. Studies describing patients with a potentially epileptogenic comorbid lesion close to their seizure focus were excluded. Descriptive statistical analyses were performed to synthetize patient characteristics. The methodological quality of each study was evaluated using a standardized appraisal tool. Results In total, 66 patients were included from 39 articles. The frontal lobe was the most common location for DVAs. The superior sagittal sinus drained half of the DVAs. Seizures were inaugural in most cases, and the most common manifestations accompanying seizures were headaches. EEG was abnormal in 93% of cases, but only 26% had characteristic epileptic spikes. More than half the patients suffered a medical complication due to their DVA, with hemorrhage and thrombosis being the most common. Refractory seizures were encountered in 19% of individuals. At 12 months of follow‐up, 75% of patients were seizure free. Most included studies were at low risk of bias. Significance Epilepsy can be a complication of DVAs; these DVAs are mostly frontal or parietal, draining via the superior sagittal sinus or the vein of Galen.

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Intracerebral Hemorrhage due to Venous Thrombosis of Developmental Venous Anomaly during Pregnancy

Cited by 13 publications

References 9 publications

Developmental venous anomaly presenting as a spontaneous intraparenchymal hematoma without thrombosis

Developmental venous anomaly presenting as a spontaneous intraparenchymal hematoma without thrombosis

Paediatric presentation of intracranial haemorrhage due to thrombosis of a developmental venous anomaly

Epilepsy and cerebral developmental venous anomalies (DVAs): A systematic review

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