Intracerebral Plasma Cell Tumor in a Cat: A Case Report and Literature Review

Feline Respiratory Extramedullary Plasmacytoma with Lymph Node Metastasis and Intrahistiocytic Amyloid

“…This case represents an extramedullary mature type plasmacytoma involving the upper and lower respiratory tract with lymph node metastasis. The patient was a geriatric male, consistent with the higher reported incidence of EMPs in older male cats (Majzoub et al, 2003;Michau et al, 2003;Greenberg et al, 2004). Although the majority of human EMPs reportedly arise within the upper respiratory tract (dos Anjos Corvo et al, 2013), this is a rare location in small animals, with only a few case reports describing primary laryngeal and tracheal EMPs in dogs, and one report involving the nasal cavity and frontal sinus of a cat (Chaffin et al, 1998;Weigt and McCracken, 2001;Hayes et al, 2007;Sch€ oniger et al, 2007;Witham et al, 2012).…”

“…In the previously reported case of sinonasal EMP in a cat, the neoplasm was limited to the nasal cavity and frontal sinus (Sch€ oniger et al, 2007). In the case of an intracerebral EMP in a cat, the neoplasm was more infiltrative, involving the leptomeninges, ventricular system, subependymal tissue and the habenular nucleus (Greenberg et al, 2004). However, to our knowledge, the present case is the first report of extensive infiltration by an EMP within the upper and lower respiratory tract.…”

“…An uncommon neoplasm in cats, the majority of cases are cutaneous (Majzoub et al, 2003), although there are rare reports of non-cutaneous EMPs, including those of sinonasal (Sch€ oniger et al, 2007), gastrointestinal (Rowland and Linke, 1994;Zikes et al, 1998), cerebral (Greenberg et al, 2004), intraocular (Michau et al, 2003), lip and gingival origin (Kyriazidou et al, 1989). With the exception of the intracerebral and sinonasal cases, most EMPs are described as well-circumscribed, non-infiltrative masses (Majzoub et al, 2003;Greenberg et al, 2004;Sch€ oniger et al, 2007). Additionally, although primary local extracellular amyloidosis with secondary granulomatous inflammation is wellreported in plasma cell dyscrasias in animals (Rowland and Linke, 1994;Majzoub et al, 2003;Gross et al, 2005), extensive accumulation of intrahistiocytic amyloid is unusual.…”

The Central Nervous System

“…14-32A&B). Other round cell tumors (Sheppard et al, 1997;Greenberg et al, 2004) are less common and include encephalic and spinal plasma cell tumors (Fig. 14-33A-C), histiocyticappearing neoplasms (Fig.…”

Seroprevalence of Toxoplasma gondii in Cats From St. Kitts, West Indies

“…More serious manifestations, especially in cats, involve the eyes (ophthalmomyiasis; Johnson et al, 1988;Harris et al, 2000;Wyman et al, 2005;Stiles and Rankin, 2006), respiratory system (nasal/pharyngeal/tracheal myiasis; Thirloway, 1982;Fitzgerald et al, 1996;Dvorak et al, 2000), or central nervous system (cerebrospinal myiasis; Cook et al, 1985;Hendrix et al, 1989;Glass et al, 1998;King, 2000). In these cases, clinical signs and symptoms can include anorexia, lethargy, inflammation, retinal damage, impaired vision, dyspnea, seizures, paralysis, or a combination, and definitive diagnoses can be difficult (many of the above references; also see Greenberg et al, 2004). Treatments for these conditions are often experimental and of uncertain efficacy, and the outcome may be fatal, either because the animal dies outright or is killed.…”