Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex

Baudena, Patrick; Halgren, Eric; Heit, Gary; Clarke, Jeffrey M.

doi:10.1016/0013-4694(95)98476-o

Cited by 400 publications

(227 citation statements)

References 39 publications

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“…The observation that a simple cognitive task such as target detection in an auditory oddball experiment induces spatially and temporally widespread neuronal responses (Baudena, et al, 1995;Calhoun, et al, 2006c;Eichele, et al, 2005;Halgren, et al, 1995a;Halgren, et al, 1995b;Kiehl, et al, 2005) pertains to distributed network responses more than to compartmentalized effects (Fox, et al, 2005;Halgren, et al, 1995c;Nunez, 2000). We see a major utility for parallel ICA in this context as it provides the means to disentangle and visualize these networks both in their spatial and temporal form (Calhoun, et al, 2006a;Debener, et al, 2006;Makeig, et al, 2004a;McKeown, et al, 2003;Onton, et al, 2006).…”

Section: Area Of Applicationmentioning

confidence: 89%

“…For example, auditory target detection induces hemodynamic activation in about fourty cortical, subcortical and cerebellar regions (Kiehl, et al, 2005), complementing the results from intracranial recordings (Baudena, et al, 1995;Halgren, et al, 1995a;Halgren, et al, 1995b). These neuronal mass responses can be observed across scales and modalities from single unit recordings, intracranial and scalp electrophysiology, as well as metabolic and hemodynamic signals, but no single technique provides a sufficient view of the full temporal, spatial and functional extent of these responses.…”

Section: Introductionmentioning

confidence: 89%

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Unmixing concurrent EEG-fMRI with parallel independent component analysis

Eichele

Calhoun

Moosmann

et al. 2008

International Journal of Psychophysiology

104

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Concurrent event-related EEG-fMRI recordings pick up volume-conducted and hemodynamically convoluted signals from latent neural sources that are spatially and temporally mixed across the brain, i.e. the observed data in both modalities represent multiple, simultaneously active, regionally overlapping neuronal mass responses. This mixing process decreases the sensitivity of voxel-byvoxel prediction of hemodynamic activation by the EEG when multiple sources contribute to either the predictor and/or the response variables. In order to address this problem, we used independent component analysis (ICA) to recover maps from the fMRI and timecourses from the EEG, and matched these components across the modalities by correlating their trial-to-trial modulation. The analysis was implemented as a group-level ICA that extracts a single set of components from the data and directly allows for population inferences about consistently expressed function-relevant spatiotemporal responses. We illustrate the utility of this method by extracting a previously undetected but relevant EEG-fMRI component from a concurrent auditory target detection experiment. §Corresponding Author:

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Section: Area Of Applicationmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 89%

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Eichele

Calhoun

Moosmann

et al. 2008

International Journal of Psychophysiology

104

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“…These imaging findings support observations of larger P300 amplitude over the right compared to left frontal/ central areas for a variety of stimulus types in an oddball task Mertens and Polich, 1997b). Communication between the frontal to temporal/parietal areas appears to be propagated across the corpus callosum to affect ERP morphology (Barcelo et al, 2000;Baudena et al, 1995;Satomi et al, 1995). This pathway contributes to P300 differences between handedness groups: Left-handers have larger callosal pathways than right-handers (Driesen and Raz, 1995;Witelson, 1992), and larger P300 amplitudes with shorter latencies have been found for left-compared to right-handed individuals Polich, 1995, 1997;Polich and Hoffman, 1998).…”

Section: P300 As Inhibition: a Hypothesismentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

6,455

458

6,265

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The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/ standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulusdriven frontal attention mechanisms during task processing, whereas P3b originates from temporalparietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

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“…In these studies, target stimuli produced activity in the ventral frontotemporal cortices, superior temporal sulcus, posterior parietal cortex, and the hippocampus, suggesting that these areas are neural generators associated with target-elicited P3 ERPs (Baudena et al, 1995;Halgren, 1980;Halgren et al, 1995a;Halgren et al, 1995b; Halgren et al, 1998). Halgren and colleagues concluded that widespread brain activation involves integration of stimulus processing and context, which is necessary for the online monitoring of performance.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Stevens

Laurens

Liddle

et al. 2006

International Journal of Psychophysiology

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Event-related potential (ERP) studies have shown that the neural systems engaged during performance of oddball tasks are sensitive to contextual manipulations, such as the number of stimulus classes. Some ERP components (i.e., N1) are modulated by the number of stimulus types, while others (i.e., P3) are not greatly affected. However, little is known about how these contextual manipulations affect the hemodynamics underlying oddball processing. The purpose of this study was to examine the hemodynamic correlates of target stimulus processing in singletone (targets alone) and two-tone (targets and standard tones) auditory oddball tasks. The primary hypothesis was that processing of salient stimuli in both contextual conditions would engage the same spatially distributed cortical and subcortical networks observed in previous oddball fMRI studies. Results were consistent with this hypothesis and suggest that the brain engages many potentially useful brain regions during salient stimulus processing despite the low probability that said regions are necessary for task performance, which likely reflects a form of "adaptive reflexive processing." Results also were consistent with ERP data that shows the N1 is larger for single-tone tasks by showing greater amplitude of hemodynamic response for singletone targets, relative to two tone targets, in bilateral temporal cortex and bilateral inferior lateral frontal cortex. The results are discussed as they relate to the understanding of neurocognitive function pertaining to contextual manipulations in general, and orienting processes in particular. Keywords ORIENTING; MAGNETIC RESONANCE IMAGING; BRAIN; PSYCHOLOGY; COGNITIONThe neural systems underlying processing of low probability target stimuli have been studied for over four decades. The impact of salient stimulus processing on brain electrical activity was first described by Sutton et al. (1965), who demonstrated that infrequently-presented taskrelevant stimuli ("oddballs") produce a sequence of time-locked electrical components, the NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript most prominent of which is a large positive potential that peaks approximately 300 milliseconds following the stimulus onset. This late event-related potential (ERP), termed the P300 or P3, is thought to reflect stimulus evaluation/categorization, and cognitive processes necessary to update mental models of context within working memory (Donchin & Coles, 1988). Since Sutton et al's seminal study, numerous reports have been published that detail how contextual manipulations in the oddball paradigm (e.g., manipulations of stimulus probability, inter-trial interval, sensory modality, etc.) modulate the latency, amplitude or topographic distribution of the P3 .One contextual manipulation to the oddball task is to alter the number of stimulus classes presented within the task. Researchers most commonly use oddball tasks having either twostimulus classes (low probability targets juxtaposed with frequent standards) or ...

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Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex

Cited by 400 publications

References 39 publications

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Updating P300: An integrative theory of P3a and P3b

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

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