Intracerebral recording of movement related readiness potentials: an exploration in epileptic patients

Rektor, Ivan; Fève, A; Buser, P; Bathien, N; Lamarche, M

doi:10.1016/0013-4694(94)90145-7

Cited by 99 publications

(45 citation statements)

References 26 publications

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“…Results from intracranial recordings of the readiness potential, like the results from dipole source analyses, challenge the predominant view that the readiness poten tial is generated by sequential activation of SMA and ML But while the dipole source analyses failed to find signifi cant premovement SMA activity, intracranial recordings confirmed SMA activity preceding voluntary movements (Ikeda et al, 1992;Rektor et al, 1994). However, this activity was not distinguishable, either in time course or amplitude, from the activity recorded over MI.…”

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confidence: 58%

“…Premovement elec trical activity in the SMA has been recorded intrac rani ally in humans (Ikeda et al, 1992;Rektor et al, 1994), while PET and fMRI have shown SMA activation, even with simple movements (e.g. Colebatch et al, 1991;Shibasaki et al, 1993;Boecker et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, dipolar sources located in the SMA at both sides of the interhemispheric cleft might (partially) cancel each other (Lang et al, 1991). We want to consider yet another explanation, which is closely related to recent results from intracranial recordings of the readiness potential (Ikeda et al, 1992;Rektor et al, 1994).…”

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confidence: 99%

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Dipole source analysis suggests selective modulation of the supplementary motor area contribution to the readiness potential

Praamstra¹,

Stegeman²,

Horstink³

et al. 1996

Electroencephalography and Clinical Neurophysiology

138

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The readiness potential preceding voluntary movement is modulated by the mode of movement selection, i.e. it has a higher ampli tude preceding freely selected than before prescribed movements (Praamstra, P., Stegeman, D,F., Horstink, M.W.I.M., Brunia, C.H.M. and Cools, A.R. Movement-related potentials preceding voluntary movement are modulated by the mode of movement selection. Exp. Brain Res., i 995, 103: 429-439). One cortical area that is likely to be involved in this modulation is the supplementary motor area (SMA). Recent attempts to elucidate the neural generators of the readiness potential using spatiotemporal dipole source analysis, how ever, failed to establish a significant SMA contribution to the readiness potential. This might be explained by a failure of the proposed analyses to discriminate between SMA and motor cortex contributions to the readiness potential. We applied a dipole source analysis approach that better separates these overlapping source activities* The resulting source model includes an SMA source generating pre movement activity consistent with evidence from intracranial recordings in humans. The SMA source accounts almost completely for the modulation of the readiness potential by different modes of movement selection. On the basis of these results, the relation between scalp-recorded movement-related activity, intracranially recorded potentials, and findings from functional imaging studies of voluntary movement, appears more transparent than suggested by previous dipole source analyses of premovement potentials.

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confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Dipole source analysis suggests selective modulation of the supplementary motor area contribution to the readiness potential

Praamstra¹,

Stegeman²,

Horstink³

et al. 1996

Electroencephalography and Clinical Neurophysiology

138

View full text Add to dashboard Cite

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“…In a series of studies with intracerebral recordings of brain electrical activity, we have mapped brain activity related to simple and complex self-paced movements, and our knowledge of the map of electrically active brain areas in this kind of protocol is quite reliable (Rektor et al, 1994(Rektor et al, , 1998(Rektor et al, , 2001b(Rektor et al, , c, 2003.…”

Section: Introductionmentioning

confidence: 99%

“…In a protocol with self-paced dot writing, we observed significant activation in regions known to participate in motor control: Contralateral to the movement in the primary sensorimotor and supramarginal cortices, the supplementary motor area (SMA) and the underlying cingulate, and, to a lesser extent, the sensorimotor region ipsilateral to the writing hand. When the fMRI was compared with the map of the brain areas electrically active with self-paced movements (intracerebral recordings; Rektor et al, 1994Rektor et al, , 1998Rektor et al, , 2001Rektor et al, , b, c, 2003, there was an evident overlap of most results. Nevertheless, the electrophysiological studies were more sensitive in uncovering small active areas, i.e., in the premotor and prefrontal cortices.…”

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confidence: 99%

An Event-Related fMRI Study of Self-Paced Writing of Simple Dots

Rektor

Rektorová

Mikl

et al. 2006

Journal of Psychophysiology

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Abstract. The spatial locations of brain activation related to self-paced repetitive movements, i.e., writing simple dots, were studied using event-related fMRI. Ten healthy right-handed subjects were scanned while performing the protocol with self-paced repetitive movement. In a protocol with self-paced dot writing, we observed significant activation in regions known to participate in motor control: Contralateral to the movement in the primary sensorimotor and supramarginal cortices, the supplementary motor area (SMA) and the underlying cingulate, and, to a lesser extent, the sensorimotor region ipsilateral to the writing hand. When the fMRI was compared with the map of the brain areas electrically active with self-paced movements (intracerebral recordings; Rektor et al., 1994Rektor et al., , 1998Rektor et al., , 2001Rektor et al., , b, c, 2003, there was an evident overlap of most results. Nevertheless, the electrophysiological studies were more sensitive in uncovering small active areas, i.e., in the premotor and prefrontal cortices. The Bereitschafspotential (BP) with Movement Accompanying Potential (MAP) and hemodynamic changes overlap in regions where the BP were displayed consistently. In some other regions, the BP recordings were inconsistent, i.e., in the prefrontal cortex, where about half of the contacts displayed BP generators while the other half did not. In these regions the hemodynamic changes were not significant. The spatial limitations of the intracerebral electrodes is a result of the fact that the electrodes are submerged in the cerebral tissue and record in their immediate vicinity. The fMRI that indirectly measures activity of larger populations of neurons has better spatial resolution. Electrophysiological techniques with intracranial recordings may reveal even subtle generators of electrical activity.

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Coregistration of EEG and fMRI in a simple motor task

et al. 1996

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The purpose of this study was to evaluate the adequacy of coregistration of movement-related cortical potentials (MRCPs) and functional magnetic resonance imaging (fMRI) data in the primary sensorimotor cortex. Data were acquired in four normal subjects during right and left simple index finger movements. In fMRI (single-slice, 1.5 Tesla, T2*-weighted FLASH sequence), contralateral primary motor (M1) and primary sensory cortex (S1) were activated in all subjects. Spatiotemporal dipole modelling of electric MRCP generators (BESA) revealed two main sources in the central region contralateral to the moving finger. Both sources were tangentially oriented. Their configuration was consistent with source locations in the anterior (M1) and posterior (S1) banks of the central sulcus. Accordingly, the M1 source generated the pre-movement, the S1 source largely the immediate post-movement MRCP component. Taken together, MRCP modelling and fMRI data indicated a phasic sequential activation pattern of mostly sulcal portions of contralateral M1 and S1. After coregistration of anatomical MRI, fMRI, and dipole modelling results, the average 3D-distance between fMRI activation areas and MRCP source locations was 18.6 mm (SD 7.6), with the largest deviation in the anterior-posterior direction (12.1+/-9.5 mm). Coregistration inaccuracies of similar magnitude (approximately 17 mm) have been reported previously with MEG and PET or fMRI. We conclude, therefore, that the combination of EEG and fMRI is a promising technique for validation of electrophysiological source models and for evaluation of human functional brain anatomy with both adequate spatial and temporal resolution.

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Intracerebral recording of movement related readiness potentials: an exploration in epileptic patients

Cited by 99 publications

References 26 publications

Dipole source analysis suggests selective modulation of the supplementary motor area contribution to the readiness potential

Dipole source analysis suggests selective modulation of the supplementary motor area contribution to the readiness potential

An Event-Related fMRI Study of Self-Paced Writing of Simple Dots

Coregistration of EEG and fMRI in a simple motor task

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