Intracerebral Venous Angioma

Sarwar, Mohammad

doi:10.1001/archneur.1978.00500290069012

Cited by 385 publications

(136 citation statements)

References 10 publications

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“…Most studies demonstrated increased hemorrhage rates after a prior hemorrhage 2,15,23 and in females. 2,20,27 The latter is reinforced by several reports purporting a hormonal responsiveness of CMs 2,24,26 and by the finding of estrogen receptors on CMs. 24 Gazzaz et al 12 reported a case of a 26-year-old woman who suffered 4 hemorrhages from a thalamic CM, each occurring 3 weeks after starting hormonal therapy and never recurring once hormonal treatment ceased.…”

Section: Discussionmentioning

confidence: 79%

“…Although reported as a risk factor in some retrospective studies as well, 7,17 all other prospective studies we evaluated did not demonstrate lesion location as a significant risk factor for hemorrhage. 2,15,20,27 This can likely be explained in part by the definition of hemorrhage in each study. Moriarity et al and Robinson et al used a strict definition of extralesional blood and new symptoms.…”

mentioning

confidence: 99%

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The natural history of intracranial cavernous malformations

Gross

Lin

et al. 2011

FOC

276

236

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Literature reports on the natural history of cerebral cavernous malformations (CMs) are numerous, with considerable variability in lesion epidemiology, hemorrhage rates, and risk factors for hemorrhage. In this review, the authors performed a meta-analysis of 11 natural history studies. The overall male-to-female ratio was 1:1, and the mean age at presentation was 30.6 years. Overall, 37% of patients presented with seizures, 36% with hemorrhage, 23% with headaches, 22% with focal neurological deficits, and 10% were asymptomatic. Some patients had more than one symptom. Seizure presentation was most prevalent among supratentorial CMs, while focal neurological deficits were common in patients with infratentorial CMs. By location, CMs were in the cerebral hemispheres (66%), brainstem (18%), basal ganglia or thalamus (8%), cerebellum (6%), and other (2.5% [combined supra- and infratentorial, callosal or insular]). Overall, 19% of patients harbored multiple intracranial CMs, and 9% had radiographically apparent associated developmental venous anomalies. An overall annual hemorrhage rate of 2.4% per patient-year (range 1.6%–3.1%) was identified across 3 studies. Prior hemorrhage and female sex were risk factors for bleeding, while CM size and multiplicity did not affect hemorrhage rates. Although not impacting the hemorrhage rate itself, deep location was a risk factor for increased clinical aggressiveness.

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Section: Discussionmentioning

confidence: 79%

mentioning

confidence: 99%

The natural history of intracranial cavernous malformations

Gross

Lin

et al. 2011

FOC

276

236

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“…The classic autopsy prevalence is 0.4%. 61 The imaging prevalence of incidental cavernomas in childhood has been estimated at 0.3%, and prevalence seems to increase with age. 62 Cavernomas become symptomatic either with seizures or from hemorrhage.…”

Section: Incidental Vascular Lesionsmentioning

confidence: 99%

“…DVMs are common incidental imaging findings with an autopsy prevalence of 2.5%. 61 They can be seen at any level of the neuraxis, but in the cerebral hemispheres they have a typical morphology: a dominant, radially oriented vein drains superficially or deeply and converging on the origin of this vein are a number of smaller tributaries. This typical morphology, the "caput medusae," recalls the appearance of snakes emanating from the head of Medusa in Greek mythology.…”

Section: Incidental Vascular Lesionsmentioning

confidence: 99%

Incidental Findings on Brain and Spine Imaging in Children

Maher¹,

Piatt²,

Ragheb³

et al. 2015

Pediatrics

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In recent years, the utilization of diagnostic imaging of the brain and spine in children has increased dramatically, leading to a corresponding increase in the detection of incidental findings of the central nervous system. Patients with unexpected findings on imaging are often referred for subspecialty evaluation. Even with rational use of diagnostic imaging and subspecialty consultation, the diagnostic process will always generate unexpected findings that must be explained and managed. Familiarity with the most common findings that are discovered incidentally on diagnostic imaging of the brain and spine will assist the pediatrician in providing counseling to families and in making recommendations in conjunction with a neurosurgeon, when needed, regarding additional treatments and prognosis.

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“…The incidence of DVA is 2.5% at autopsies [1]. It is the most common incidental brain vascular malformation detected in adults [2], but rarely found by US in neonates.…”

mentioning

confidence: 99%