Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment

Spadaro, Francesco; Dunn, Adrian J.

doi:10.1016/0889-1591(90)90034-n

Cited by 98 publications

(38 citation statements)

References 36 publications

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“…These include decreased locomotor activity (Otterness et al, 1988), exploration (Spadaro and Dunn, 1990;Dunn et al, 1991), and feeding (McCarthy et al, 1985), behaviors that may be displayed by fearful or anxious animals. These well-documented findings raised the question of whether IL-1 may mediate fear or anxiety-like behavior in animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Świergiel

Dunn

2007

Pharmacology Biochemistry and Behavior

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186

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It has been postulated that infections, inflammatory processes and resulting cytokines may be causative factors in emotional disorders, including depression and anxiety. Support for this possibility has been sought in studies of animal behavior following administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS). However, such treatments induce a variety of behavioral responses, collectively known as sickness behavior, some of which could affect the performance in tests used to assess anxiety and depression. Thus the effects of peripheral administration of IL-1β and LPS on the behavior of mice were studied in the elevated plus-maze (EPM) and the open field (OF). Mouse IL-1β (30, 100, 300, and 1000 ng) was injected intraperitoneally 30 or 60 min, and LPS (0.5, 1 and 5 μg) 120 minutes before the tests.IL-1β and LPS induced dose-dependent decreases in open arm entries and the time spent on the open arms in the EPM, effects considered to reflect anxiety-like behavior. However, entries to all arms were also reduced in a dose-dependent manner, indicating a decrease in general activity. In the OF, IL-1β and LPS decreased the number of line-crossings in the center of the field, that can also be considered to reflect anxiety-like behavior. However, this effect was accompanied by a similar decrease in line-crossings in the periphery, as well as in rears and climbs. Thus the doses of IL-1β and LPS necessary to induce these effects also decreased locomotor activity in the EPM and OF. Therefore, the behavioral responses induced by IL-1β and LPS in the EPM and the OF considered to reflect anxiety must be interpreted in the light of this reduction in overall activity. Thus the results do not provide unequivocal support for the suggestion that LPS or IL-1 mediate anxiety. Nevertheless, because infections, endotoxins, and the ensuing cytokines cause alterations in CNS norepinephrine and serotonin, they may contribute to emotionality, and perhaps to anxiety.

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Section: Introductionmentioning

confidence: 99%

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Świergiel

Dunn

2007

Pharmacology Biochemistry and Behavior

Self Cite

186

106

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“…Following a simulated infection (treatment with LPS), hamsters housed in short days exhibit shorter fevers relative to those housed in long days [7]; the magnitude and duration of anorexia, cachexia, and anhedonia are likewise attenuated in short days [19][20]. Accompanying the abrogation of sickness behaviors are decreases in peripheral production of IL-1β, IL-6, and TNF-α [7,21] and in brain production of IL-1β and TNF-α [22].…”

Section: Introductionmentioning

confidence: 99%

Photoperiodic regulation of behavioral responsiveness to proinflammatory cytokines

Wen

Prendergast

2007

Physiology & Behavior

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Symptoms of bacterial infection include decreases in body mass (cachexia), induction of depressivelike hedonic tone (anhedonia), decreases in food intake (anorexia), and increases in body temperature (fever). Recognition of bacteria by the innate immune system triggers the release of proinflammatory cytokines which induce these sickness behaviors via central and peripheral substrates. In Siberian hamsters, exposure to short day lengths decreases both the production of proinflammatory cytokines and the magnitude of the symptoms of infection. Short-day attenuation of sickness behaviors may arise solely from decreased production of cytokines; alternatively, substrates responsible for the generation of sickness behaviors may be less responsive to cytokines in short days. To discriminate among these hypotheses, Siberian hamsters were treated with either bacterial lipopolysaccharide (LPS; 25 μg) or recombinant mouse IL-1β (rIL-1β; 100 ng) following 11 weeks of exposure to long (15 h light/day) and short (9 h light/day) photoperiods. Replicating earlier work, the magnitude and/ or duration of LPS-induced anorexia, anhedonia, cachexia, and fever were greater in long-day relative to short-day hamsters. A comparable short-day attenuation of sickness behaviors and fever was obtained in response to rIL-1β treatment, despite treatment with identical concentrations of cytokine. These data suggest that hamsters subjected to immunoenhancing short days exhibit diminished symptoms of infection not solely because infections elicit lower levels of cytokine production, but also because the substrates upon which cytokines act become relatively refractory.

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“…Spadaro e Dunn (1990) verificaram que após 20 minutos da administração intracerebroventricular (ICV) de IL-1 camundongos tiveram a atividade exploratória diminuída. Nestas condições, os parâmetros relativos à atividade geral e grooming não sofreram qualquer alteração (SPADARO; DUNN, 1990). Outra alteração comportamental observada após a injeção de IL-1 foi a presença de anorexia (HELLERSTEIN et al, 1989).…”

Section: Revisão De Literatura ______________________________________unclassified

“…Assim, há trabalhos mostrando que as alterações comportamentais são dependentes do CRF produzido no hipotálamo (DUNN; ANTOON; CHAPMAN, 1991) e outros negando tal fato SPADARO;DUNN, 1990). Há, também, trabalhos demonstrando a participação das prostaglandinas nas alterações comportamentais ocasionadas pela injeção de IL-1 HELLERSTEIN et al, 1989).…”

Section: Revisão De Literatura ______________________________________unclassified

Percepção neural da alergia alimentar: envolvimento de mecanismos dependentes de IgE e das fibras nervosas do tipo C

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Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment

Cited by 98 publications

References 36 publications

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Photoperiodic regulation of behavioral responsiveness to proinflammatory cytokines

Percepção neural da alergia alimentar: envolvimento de mecanismos dependentes de IgE e das fibras nervosas do tipo C

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