Intracerebroventricular administration of urotensin II promotes anxiogenic-like behaviors in rodents

Matsumoto, Yoshio; Abe, Michiko; Watanabe, Takuya; Adachi, Yuko; Yano, Takahiko; Takahashi, Hideki; Sugo, Tsukasa; Mori, Masataka; Kitada, Chieko; Kurokawa, Tsutomu; Fujino, Masahiko

doi:10.1016/j.neulet.2003.12.116

Cited by 35 publications

(30 citation statements)

References 17 publications

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“…Moreover, it increases locomotor activity (Gartlon et al 2001). Recently, in a study conducted on mice, Matsumoto et al (2004) have shown that the central administration of bovine U-II promotes anxious-like behaviors evidenced through either the elevated plus-maze test or the hole-board test. However, except for these two behavioral effects, no other test seems to have been explored.…”

Section: Discussionmentioning

confidence: 99%

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Behavioral effects of urotensin-II centrally administered in mice

do-Rego

Chatenet²,

Orta³

et al. 2005

Psychopharmacology

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Urotensin-II (U-II) receptors are widely distributed in the central nervous system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, the behavioral effects of centrally administered U-II have received little attention. In the present study, we tested the effects of i.c.v. injections of U-II on behavioral, metabolic, and endocrine responses in mice. Administration of graded doses of U-II (1-10,000 ng/mouse) provoked: (1) a dose-dependent reduction in the number of head dips in the hole-board test; (2) a dose-dependent reduction in the number of entries in the white chamber in the black-and-white compartment test, and in the number of entries in the central platform and open arms in the plus-maze test; and (3) a dose-dependent increase in the duration of immobility in the forced-swimming test and tail suspension test. Intracerebroventricular injection of U-II also caused an increase in: food intake at doses of 100 and 1,000 ng/mouse, water intake at doses of 100-10,000 ng/mouse, and horizontal locomotion activity at a dose of 10,000 ng/mouse. Whatever was the dose, the central administration of U-II had no effect on body temperature, nociception, apomorphine-induced penile erection and climbing behavior, and stress-induced plasma corticosterone level. Taken together, the present study demonstrates that the central injection of U-II at doses of 1-10,000 ng/mouse induces anxiogenic- and depressant-like effects in mouse. These data suggest that U-II may be involved in some aspects of psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

“…However, the behavioral effects of centrally administered U-II have received little attention, with the exception of a very recent report showing that i.c.v. injection of U-II induces anxiogenic-like effects in rodents (Matsumoto et al 2004). …”

Section: Introductionmentioning

confidence: 99%

Behavioral effects of urotensin-II centrally administered in mice

do-Rego

Chatenet²,

Orta³

et al. 2005

Psychopharmacology

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“…The UT gene is expressed in brain regions involved in the control of Urotensin II and Its Receptor motivation, vigilance, and arousal such as the bed nucleus of the stria terminalis, the locus coeruleus, the ventral tegmental area, the laterodorsal tegmental nucleus, and the nucleus ambiguus (Clark et al, 2001;Gartlon et al, 2001;Jégou et al, 2006;Hunt et al, 2010). Intracerebroventricular injection of 15 pmol-3 nmol UII in mice causes anxiogenic-like effects as assessed in the black-and-white, hole-board, and elevated plus maze tests (Matsumoto et al, 2004;do Rego et al, 2005do Rego et al, , 2008 (Fig. 15).…”

Section: A Effects Of Urotensin Ii/urotensin Ii-related Peptide In Tmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

et al. 2014

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“…Thus, i.c.v. administration of UII promotes anxiogenic and depressant-like effects in mice (Matsumoto et al 2004, Do Rego et al 2005 and enhances neural activity in rat periaqueductal gray matter (Gartlon et al 2004), a central region involved in anxiety control. In addition, targeted administration of UII into the pedunculopontine nucleus modulates paradoxical sleep through the direct activation of brainstem cholinergic neurons (Huitron-Resendiz et al 2005, de Lecea & Bourgin 2008.…”

Section: Uts2r5mentioning

confidence: 99%

MOLECULAR EVOLUTION OF GPCRS: Somatostatin/urotensin II receptors

Tostivint¹,

Daza²,

Bergqvist³

et al. 2014

Journal of Molecular Endocrinology

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Somatostatin (SS) and urotensin II (UII) are members of two families of structurally related neuropeptides present in all vertebrates. They exert a large array of biological activities that are mediated by two families of G-protein-coupled receptors called SSTR and UTS2R respectively. It is proposed that the two families of peptides as well as those of their receptors probably derive from a single ancestral ligand-receptor pair. This pair had already been duplicated before the emergence of vertebrates to generate one SS peptide with two receptors and one UII peptide with one receptor. Thereafter, each family expanded in the three whole-genome duplications (1R, 2R, and 3R) that occurred during the evolution of vertebrates, whereupon some local duplications and gene losses occurred. Following the 2R event, the vertebrate ancestor is deduced to have possessed three SS (SS1, SS2, and SS5) and six SSTR (SSTR1-6) genes, on the one hand, and four UII (UII, URP, URP1, and URP2) and five UTS2R (UTS2R1-5) genes, on the other hand. In the teleost lineage, all these have been preserved with the exception of SSTR4. Moreover, several additional genes have been gained through the 3R event, such as SS4 and a second copy of the UII, SSTR2, SSTR3, and SSTR5 genes, and through local duplications, such as SS3. In mammals, all the genes of the SSTR family have been preserved, with the exception of SSTR6. In contrast, for the other families, extensive gene losses occurred, as only the SS1, SS2, UII, and URP genes and one UTS2R gene are still present.

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Intracerebroventricular administration of urotensin II promotes anxiogenic-like behaviors in rodents

Cited by 35 publications

References 17 publications

Behavioral effects of urotensin-II centrally administered in mice

Behavioral effects of urotensin-II centrally administered in mice

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

MOLECULAR EVOLUTION OF GPCRS: Somatostatin/urotensin II receptors

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