Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

Köksal, Ersin; Karakaya, Deniz; Can, Bilge; Bozkurt, Ayhan; Barış, Sibel; Bilge, S. Sırrı; Üstün, Yasemin Burcu

doi:10.5152/balkanmedj.2013.7747

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Data were presented as median and range ** highly significant * Significant. this alpha-2 agonist to produce analgesia is mediated by decreasing the release of norepinephrine [10,11]. The present study agrees with Bakr et al [12] who studied the efficacy of 1 µg/kg dexmedetomidine added to an ultrasound (US)-modified pectoral (Pecs) block on postoperative pain and stress response in patients undergoing MRM.…”

Section: Discussionsupporting

confidence: 91%

Efficacy of dexmedetomidine as an adjuvant to bupivacaine in the ultrasound-guided serratus anterior plane block for postmastectomy analgesia

Abdelzaam

Alazeem

2020

Egyptian Journal of Anaesthesia

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Section: Discussionsupporting

confidence: 91%

Efficacy of dexmedetomidine as an adjuvant to bupivacaine in the ultrasound-guided serratus anterior plane block for postmastectomy analgesia

Abdelzaam

Alazeem

2020

Egyptian Journal of Anaesthesia

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“…This alpha-2 agonist mediates peripheral analgesia by reducing the release of norepinephrine and the independent inhibition of neurofibrillary action potential by the alpha-2 receptor. None of the various animal studies showed any adverse neurological effects of DEX [ 20 , 21 ] and neuroprotective effects of dexmedetomidine, induced by intrathecal administration is similar to methylprednisolone [ 21 ]. DEX has also been used in human studies as an adjuvant for local anesthetics [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Thoracic Paravertebral Nerve Block with Ropivacaine and Adjuvant Dexmedetomidine Produced Longer Analgesia in Patients Undergoing Video-Assisted Thoracoscopic Lobectomy: A Randomized Trial

Zha

Wang

et al. 2021

Journal of Healthcare Engineering

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Purpose. This study evaluated the postoperative analgesic effect of ultrasound-guided single-point thoracic paravertebral nerve block (TPVB) combined with dexmedetomidine (DEX) in patients undergoing video-assisted thoracoscopic lobectomy. Methods. Sixty adult patients of the American Society of Anesthesiologists (ASA) I–III were randomly assigned into three groups (n = 20 each). G group: patients received routine general anesthesia; PR group: patients received 0.5% ropivacaine; and PRD group: patients received 0.5% ropivacaine with 1 μg/kg DEX. TPVB was performed in the T5 space before surgery, and then, general anesthesia induction and video-assisted thoracoscopic lobectomy were performed. Analgesics were administered through the patient-controlled analgesia (PCA) device intravenously. The background infusion of each PCA device was set to administer 0.02 μg/kg/h sufentanil, with a lockout time of 15 min, and a total allowable volume is 100 ml. Results. Compared to PR and G groups, the total sufentanil consumption after operation, the times of analgesic pump pressing, the pain score, and the incidence of postoperative nausea or vomiting in the PRD group were significantly reduced ( p < 0.05 ). Also, the duration of first time of usage of the patient-controlled analgesia (PCA) was longer. The heart rate (HR) and mean arterial pressure (MAP) during operation were lower in the PRD group as compared with the other two groups in most of the time. However, hypotension and arrhythmia occurred in three groups with no statistically significant difference. Conclusions. A small volume of TPVB with ropivacaine and DEX by single injection produced longer analgesia in patients undergoing video-assisted thoracoscopic lobectomy, reduced postoperative opioids consumption, and the incidence of side effects.

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Efficacy of dexmedetomidine as an adjuvant in paravertebral block in breast cancer surgery

et al. 2015

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Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats

Cited by 3 publications

References 30 publications

Efficacy of dexmedetomidine as an adjuvant to bupivacaine in the ultrasound-guided serratus anterior plane block for postmastectomy analgesia

Efficacy of dexmedetomidine as an adjuvant to bupivacaine in the ultrasound-guided serratus anterior plane block for postmastectomy analgesia

Thoracic Paravertebral Nerve Block with Ropivacaine and Adjuvant Dexmedetomidine Produced Longer Analgesia in Patients Undergoing Video-Assisted Thoracoscopic Lobectomy: A Randomized Trial

Efficacy of dexmedetomidine as an adjuvant in paravertebral block in breast cancer surgery

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