Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption

Lau, Benson Wui-Man; Yau, Suk-Yu; Lee, Tatia M.C.; Ching, Yick–Pang; Tang, Siu Wa; So, Kwok‐Fai

doi:10.1097/wnr.0b013e328324edcd

Cited by 17 publications

(10 citation statements)

References 23 publications

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“…The Ara-c group received oral feeding of 1 mg/kg LBP and infusion of cytosine arabinoside (Ara-c, a cytostatic drug which blocks cell proliferation) for seven days. Procedures of infusion was described previously [21]. In brief, osmotic pumps (Alzet, California, USA) filled with saline/Ara-c were implanted subcutaneously at the dorsal neck region of the rats.…”

Section: Methodsmentioning

confidence: 99%

Polysaccharides from Wolfberry Prevents Corticosterone-Induced Inhibition of Sexual Behavior and Increases Neurogenesis

Lau

Lee

et al. 2012

PLoS ONE

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Lycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of infertility and sexual dysfunction. However, there is still a scarcity of experimental evidence to support the pro-sexual effect of wolfberry. The aim of this study is to determine the effect of Lycium barbarum polysaccharides (LBP) on male sexual behavior of rats. Here we report that oral feeding of LBP for 21 days significantly improved the male copulatory performance including increase of copulatory efficiency, increase of ejaculation frequency and shortening of ejaculation latency. Furthermore, sexual inhibition caused by chronic corticosterone was prevented by LBP. Simultaneously, corticosterone suppressed neurogenesis in subventricular zone and hippocampus in adult rats, which could be reversed by LBP. The neurogenic effect of LBP was also shown in vitro. Significant correlation was found between neurogenesis and sexual performance, suggesting that the newborn neurons are associated with reproductive successfulness. Blocking neurogenesis in male rats abolished the pro-sexual effect of LBP. Taken together, these results demonstrate the pro-sexual effect of LBP on normal and sexually-inhibited rats, and LBP may modulate sexual behavior by regulating neurogenesis.

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Section: Methodsmentioning

confidence: 99%

Polysaccharides from Wolfberry Prevents Corticosterone-Induced Inhibition of Sexual Behavior and Increases Neurogenesis

Lau

Lee

et al. 2012

PLoS ONE

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“…Prepulse inhibition of the acoustic startle response is consistently unaltered by wheel running (Lau et al, 2009; Pietropaolo et al, 2006; Salam et al, 2009). In line with the idea that a history of wheel running produces beneficial effects on startle, mice that ran on a wheel for 2 wks exhibited reduced acoustic startle amplitude relative to sedentary counterparts (Salam et al, 2009).…”

Section: Effects Of Wheel Running On Anxiety-like Behavior and Feamentioning

confidence: 98%

Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms

Sciolino

Holmes

2012

Neuroscience & Biobehavioral Reviews

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Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand the mechanisms that underlie the benefits of exercise. However, it is controversial whether exercise exerts anxiolytic-like potential in rodents. Evidence is reviewed to evaluate the effects of wheel running, an experimental mode of exercise in rodents, on behavior in tests of anxiety and on norepinephrine and galanin systems in neural circuits that regulate stress. Stress is proposed to account for mixed behavioral findings in this literature. Indeed, running promotes an adaptive response to stress and alters anxiety-like behaviors in a manner dependent on stress. Running amplifies galanin expression in noradrenergic locus coeruleus (LC) and suppresses stress-induced activity of the LC and norepinephrine output in LC-target regions. Thus, enhanced galanin-mediated suppression of brain norepinephrine in runners is supported by current literature as a mechanism that may contribute to the stress-protective effects of exercise. These data support the use of rodents to study the emotional and neurobiological consequences of exercise.

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“…One is to ablate neurogenesis at the time of injury to determine whether this then impairs recovery. Strategies to do this include systemic or local administration of anti-mitotic agents such as Ara-C that are known to affect dividing neural progenitors (Doetsch et al, 1999; Lau et al, 2009). Another is to perform cranial irradiation directed to neurogenic zones such as the SVZ and dentate gyrus in order to more selectively impair neurogenesis (Hellstrom et al, 2008; Naylor et al, 2008).…”

Section: Neurogenesis Following Traumatic Brain Injurymentioning

confidence: 99%

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

Kernie

Parent

2010

Neurobiology of Disease

383

290

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Neural stem cells persist in the adult mammalian forebrain and are a potential source of neurons for repair after brain injury. The two main areas of persistent neurogenesis, the subventricular zone (SVZ)-olfactory bulb pathway and hippocampal dentate gyrus, are stimulated by brain insults such as stroke or trauma. Here we focus on the effects of focal cerebral ischemia on SVZ neural progenitor cells in experimental stroke, and the influence of mechanical injury on adult hippocampal neurogenesis in models of traumatic brain injury (TBI). Stroke potently stimulates forebrain SVZ cell proliferation and neurogenesis. SVZ neuroblasts are induced to migrate to the injured striatum, and to a lesser extent to the peri-infarct cortex. Controversy exists as to the types of neurons that are generated in the injured striatum, and whether adult-born neurons contribute to functional restoration remains uncertain. Advances in understanding the regulation of SVZ neurogenesis in general, and stroke-induced neurogenesis in particular, may lead to improved integration and survival of adult-born neurons at sites of injury. Dentate gyrus cell proliferation and neurogenesis similarly increase after experimental TBI. However, pre-existing neuroblasts in the dentate gyrus are vulnerable to traumatic insults, which appear to stimulate neural stem cells in the SGZ to proliferate and replace them, leading to increased numbers of new granule cells. Interventions that stimulate hippocampal neurogenesis appear to improve cognitive recovery after experimental TBI. Transgenic methods to conditionally label or ablate neural stem cells are beginning to further address critical questions regarding underlying mechanisms and function significance of neurogenesis after stroke or TBI. Future therapies should be aimed at directing appropriate neuronal replacement after ischemic or traumatic injury while suppressing aberrant integration that may contribute to co-morbidities such as epilepsy or cognitive impairment.

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Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption

Cited by 17 publications

References 23 publications

Polysaccharides from Wolfberry Prevents Corticosterone-Induced Inhibition of Sexual Behavior and Increases Neurogenesis

Polysaccharides from Wolfberry Prevents Corticosterone-Induced Inhibition of Sexual Behavior and Increases Neurogenesis

Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

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