Intracerebroventricular injection of kynurenic acid attenuates corticotrophin-releasing hormone-augmented stress responses in neonatal chicks

Yoshida, Junki; Tomonaga, Shozo; Ogino, Yoichiro; Nagasawa, Mao; Kurata, K.; Furuse, Mitsuhiro

doi:10.1016/j.neuroscience.2012.06.041

Cited by 16 publications

(13 citation statements)

References 20 publications

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“…Thus, it is likely that these amino acids are involved in the sedative and/or hypnotic effects of glucose. On the other hand, other amino acids which have sedative effects in chicks, such as alanine (L-alanine in Kurauchi et al, 2006), asparagine (Lasparagine in Yamane et al, 2009b), ornithine (L-ornithine in Suenaga et al, 2008b), proline (L-proline in Hamasu et al, 2009), serine (L-serine in Asechi et al, 2006) and tryptophan (L-tryptophan in Yoshida et al, 2012), had no effects in the present study. The relationship among these amino acids and sedative effects of centrally injected glucose may be weak.…”

Section: Discussioncontrasting

confidence: 60%

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

et al. 2015

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Intracerebroventricular injection of glucose can induce a sedative effect in chicks under social isolation stress. In addition, central injection of glucose improves memory formation in chicks in the passive avoidance task. In the present study, we confirmed that intracerebroventricular injection of glucose modified aspartate, arginine, glutamate, β-alanine, glycine and serine-ortho-phosphate levels of the telencephalon which are known to induce sedative effects in chicks. In addition, not only glutamate in the telenephalon, one of whose receptors is involved in the formation of memory in chicks, but also its metabolite glutamine was affected. These results suggest that some types of amino acid metabolism may be linked to the functions of glucose in the brain, attenuate the stress response and improve memory formation in chicks.

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Section: Discussioncontrasting

confidence: 60%

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

et al. 2015

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“…In addition, previous studies with i.c.v. injection of L-TRP metabolites varied in that some were with or without CRH and the concentrations of L-TRP differed, making it difficult to compare directly the efficacy of L-TRP metabolites in affecting the stress response (Zhang et al, 2004;Kurauchi et al, 2007;Yoshida et al, 2012). This study, therefore, further clarifies the functions of L-TRP metabolites.…”

Section: Introductionmentioning

confidence: 89%

“…In neonatal chicks, i.c.v. injection of DL-TRP had sedative effects under an acute stressful condition (Kurauchi et al, 2007), and L-TRP reduced stress-induced responses in neonatal chicks (Yoshida et al, 2012). However, the effect and presence of D-TRP itself in the brain have not been clarified yet.…”

Section: Introductionmentioning

confidence: 97%

“…injection, but did not have a hypnotic effect (Zhang et al, 2004). On the other hand, kynurenic acid (KYNA) had both sedative and hypnotic effects under a CRH-augmented stress (Yoshida et al, 2012). KYNA was involved in the mechanism of L-TRPmediated sedative effects and KYNA functioned via the simultaneous inhibition of the α7 nicotinic acetylcholine (α7nACh) receptor and Nmethyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B (Yoshida et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of centrally injected tryptophan-related substances inducing sedation in acute isolation stress-induced neonatal chicks

Yoshida

Erwan

Chowdhury

et al. 2015

Pharmacology Biochemistry and Behavior

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In the present study, we first focused on the function of l-tryptophan (TRP) metabolites which are synthesized in different metabolic pathways, namely, the kynurenine (KYN) pathway and serotonin (5-HT) pathway during an acute isolation stress. When l-TRP metabolites were intracerebroventricularly injected on an equimolar basis (100 nmol), 5-HT induced a sedative effect in neonatal chicks. Additionally, plasma corticosterone, dopamine, 5-HT, and its metabolite 5-hydroxyindoleacetic acid concentrations were increased in the diencephalon of the 5-HT treated group compared with other groups. Second, the two doses (400 or 800 nmol) of l- and d-TRP were compared under a corticotrophin-releasing hormone-augmented social isolation stress. When comparing the efficacy between l- and d-TRP against stress behavior, both amino acids had a similar effect and quickly suppressed distress vocalizations. Finally, d-amino acid levels in the diencephalon and telencephalon were measured but d-TRP was not found. These results indicate that l- and d-TRP induce the same effect in attenuating stress but the mode of action of TRP derivatives, namely 5-HT differs during an acute isolation stress in neonatal chick. The absence of d-TRP in the diencephalon further suggests that instead of being an endogenous factor it may play role as a pharmacological factor.

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“…Egy másik állatkísérletes modellben a stressz hatását újszülött csibéken vizsgálták, a stresszhatást itt az izoláció és a corticotropin releasing hormon injekció jelentette. Intracerebroventricularisan beadott KYNA csökkentette az állatokban a stresszre adott magatartási válaszokat, vagyis a vokalizációt, illetve spontán motoros aktivitást, és alacsonyabb lett a plazma kortikoszteronszintje is [27]. Később sikerült azt is igazolni, hogy a KYNA ezen hatásai elsősorban az NR2A és NR2B alegységeket tartalmazó NMDA-receptorokhoz köthetők [28].…”

Section: áBraunclassified

A kinureninrendszer és a stressz

Majláth

Vécsei

2015

Orvosi Hetilap

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A kinureninrendszer a triptofán metabolizmusának fő útja, amelynek során különböző neuroaktív vegyületek keletkeznek. A kinurénsav az excitátoros receptorok endogén antagonistája, amely preklinikai körülmények között neuroprotektívnek bizonyult. A kinureninek kapcsolatba hozhatóak a neuroendokrin szabályozó folyamatokkal is. A stressz számos változást vált ki a kinureninrendszerben, ez a folyamat hozzájárulhat a stresszel kapcsolatos patológiás folyamatokhoz. Az irritábilis bél szindróma és a gyomorfekély kialakulásának jól ismert a kapcsolata a pszichiátriai társbe-tegségekkel és a stresszel. Kísérletes körülmények között a kinurénsav jótékony hatásúnak bizonyult, mivel csökken-tette a bélben a gyulladásos folyamatokat és normalizálta a mikrocirkulációt. Izgalmas feladat a kinureninrendszer és a stressz kapcsolatának pontos megismerése, amely lehetőséget adhat a jövőben új terápiás lehetőségek kifejlesztésére. Orv. Hetil., 2015, 156(35), 1402-1405. Kulcsszavak: stressz, kinureninrendszer, kinurénsav, irritábilis bél szindróma Stress and the kynurenine pathwayThe kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes. Stress induces several alterations in the kynurenine metabolism and this process may contribute to the development of stress-related pathological processes. Irritable bowel disease and gastric ulcer are well-known disorders which are related to psychiatric comorbidity and stress. In experimental conditions kynurenic acid proved to be benefi cial by reducing infl ammatory processes and normalizing microcirculation in the bowel. Further investigations are needed to better understand the relations of stress and the kynurenines, with the aim of developing novel therapeutic tools for stress-related pathologies. Rövidítések 3-OH-KYN = 3-hidroxi-kinurenin; AMPA = 2-amino-3-(5-metil-3-oxo-1,2-oxazol-4-il)propánsav; IDO = indolamin-2,3-dioxigenáz; KAT = kinurenin-aminotranszferáz; KMO = kinurenin-3-monooxigenáz; KYNA = kinurénsav; NMDA = N-metil-D-aszpartát; QUIN= kvinolinsav Selye Jánosnak elévülhetetlen szerepe van a stresszelmé-let kidolgozásában, ő írta le először a stressz kapcsolatát a hypothalamohypophysealis rendszerrel. Megkülön-böztette az úgynevezett negatív stresszt vagy distresszt és a pozitív stressz, vagy más néven eustressz fogalmát. Fontos érdeme volt a stressz-szindróma leírása: mellék-vese-hypertrophia, thymusatrophia és gyomorfekély [1, 2]. Krónikus stressz fennállása esetén a szervezet megpróbál alkalmazkodni, és különböző adaptációs mechanizmusok indulnak be. Kóros esetben megjelenhetnek szervkárosodások, mint például kardiológiai kompliká-ciók vagy gyomor-bél rendszeri kórképek, így gyomorfekély vagy irritábilis bél szindróma is. Selye János munkája megalapozta a stresszel kapcsolatos kutatásokat, és bár azóta számos el...

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Intracerebroventricular injection of kynurenic acid attenuates corticotrophin-releasing hormone-augmented stress responses in neonatal chicks

Cited by 16 publications

References 20 publications

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

Comparison of centrally injected tryptophan-related substances inducing sedation in acute isolation stress-induced neonatal chicks

A kinureninrendszer és a stressz

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