Intracisternally injected galanin-(1–15) modulates the cardiovascular responses of galanin-(1–29) and the 5-HT1A receptor agonist 8-OH-DPAT

Narváez, JoséA.; Diaz, Zaida; Aguirre, J.A.; González-Barón, S; Yanaihara, N; Fuxé, Kjell; Hedlund, Peter B.

doi:10.1016/0014-2999(94)90137-6

Cited by 34 publications

(22 citation statements)

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“…Peripheral and central mechanisms of nociception and cough share similar features, such as the type of afferent fibers (A␦ and C), transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 channels, central and peripheral sensitization, as well as the involvement of mitogenactivated protein kinase (MAPK) signal transduction pathways (4,11,12,14,20,29,40). This correspondence between nociception and cough has led to investigations on the antitussive effects of agents known to be involved in the central control of pain sensation (4, 15).Galanin is a 29 amino acid neuropeptide (30 amino acids in humans) widely distributed in the central nervous system (e.g., 21,28,36,37,63,65) involved in many body functions such as feeding behavior, learning and memory, neuroendocrine control, mood disorders, antinociception, cardiovascular regulation, and respiration (1,6,28,44). In particular, galanin has been implicated in the descending control of pain at the spinal level as well as in its modulation at supraspinal sites probably mainly via galanin-1 (GAL 1 ) receptors (e.g.,2,22,32,68; reviewed in Refs.…”

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“…Galanin is a 29 amino acid neuropeptide (30 amino acids in humans) widely distributed in the central nervous system (e.g., 21,28,36,37,63,65) involved in many body functions such as feeding behavior, learning and memory, neuroendocrine control, mood disorders, antinociception, cardiovascular regulation, and respiration (1,6,28,44). In particular, galanin has been implicated in the descending control of pain at the spinal level as well as in its modulation at supraspinal sites probably mainly via galanin-1 (GAL 1 ) receptors (e.g.,2,22,32,68; reviewed in Refs.…”

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Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Mutolo

Cinelli

Bongianni

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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The caudal nucleus tractus solitarii (NTS) is the main central station of cough-related afferents and a strategic site for the modulation of the cough reflex. The similarities between the characteristics of central processing of nociceptive and cough-related inputs led us to hypothesize that galanin, a neuropeptide implicated in the control of pain, could also be involved in the regulation of the cough reflex at the level of the NTS, where galanin receptors have been found. We investigated the effects of galanin and galnon, a nonpeptide agonist at galanin receptors, on cough responses to mechanical and chemical (citric acid) stimulation of the tracheobronchial tree. Drugs were microinjected (30 -50 nl) into the caudal NTS of pentobarbital sodium-anesthetized, spontaneously breathing rabbits. Galnon antitussive effects on cough responses to the mechanical stimulation of the airway mucosa via a custom-built device were also investigated. Bilateral microinjections of 1 mM galanin markedly decreased cough number, peak abdominal activity, and increased cough-related total cycle duration. Bilateral microinjections of 1 mM galnon induced mild depressant effects on cough, whereas bilateral microinjections of 10 mM galnon caused marked antitussive effects consistent with those produced by galanin. Galnon effects were confirmed by using the cough-inducing device. The results indicate that galanin receptors play a role in the inhibitory control of the cough reflex at the level of the caudal NTS and provide hints for the development of novel antitussive strategies. airway defensive reflexes; galanin; galanin receptors; galnon; nucleus tractus solitarii COUGH IS A VERY IMPORTANT airway protective reflex and is one of the most common reason why patients seek medical attention. Cough is purposeful and useful under many circumstances, but in case of persistent or chronic cough (e.g., 15) is without an apparent aim and benefit and can results in a wide range of physical and psychological complications including urinary incontinence, insomnia, depression, and anxiety. The efficacy of antitussive drugs is far from clear from the available evidence and, in addition, limited by important side effects. Therefore, further research to find better antitussive approaches is necessary (for reviews see Refs. 4 and 15). Studies undertaken to provide insights into the neural mechanisms subserving the cough reflex may also provide useful suggestions for novel antitussive therapeutic strategies. The cough reflex involves several brain stem structures that also underlie respiratory rhythm generation (e.g., 7,9,10,19,24,27,[47][48][49]55).In particular, the nucleus tractus solitarii (NTS), especially in its caudal aspects, is the main central terminus of cough-related afferents (14, 39 -41, 43, 53 also for further references) and, in addition, a possible strategic site of synaptic plasticity, where cough-related sensory inputs can be modulated (e.g., 10,14,34,39,40,43).In recent years, we and other researchers have focused our attention on the s...

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Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Mutolo

Cinelli

Bongianni

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…GAL is involved in a variety of functions, such as learning and memory, pain control, food intake, neuroendocrine control, and central cardiovascular regulation (Crawley, 1996;Wrenn and Crawley, 2001;Wynick et al, 2001;Narvaez et al, 1994).…”

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confidence: 99%

Galanin inhibits calcium channels via Gαi-protein mediated by GalR1 in rat nucleus tractus solitarius

et al. 2008

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Galanin (GAL), a 29-amino-acid neuropeptide, is involved in various neuronal functions, including the regulation of food intake, hormone secretion and central cardiovascular regulation. The nucleus tractus solitarius (NTS) is known to plays a major role in the regulation of cardiovascular, respiratory, gustatory, hepatic and swallowing functions.Voltage-dependent Ca 2+ channels (VDCCs) serve as crucial mediators of membrane excitability and Ca 2+ -dependent functions such as neurotransmitter release, enzyme activity and gene expression. The purpose of this study was to investigate the effects of GAL on VDCCs currents (ICa) carried by Ba 2+ (IBa) in the NTS using patch-clamp recording methods. An application of M617 (GalR1 specific agonist), AR-M961 (GAL receptor GalR 1/2 agonist) and GAL caused inhibition of N-and P/Q-types IBa. M617, GAL, and AR-M961 caused inhibition of IBa in a concentration-dependent manner, with IC50's of 678 nM, 325 nM and 573 nM, respectively. This inhibition was relieved, albeit incompletely, by a depolarizing prepulse. Pretreatment with M35 (GalR non-specific antagonist) attenuated the M617-induced inhibition of IBa. Intracellular dialysis of the G i-protein antibody also attenuated the Gal-induced inhibition of IBa. These results indicate that GAL inhibits N-and P/Q-types VDCCs via G i -protein subunits 3 mediated by GalR1 in NTS.

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“…Recently the involvement of galanin and galanin fragments on central cardiovascular regulation has been demonstrated. Galanin administered intracisternally elicits a weak vasodepressor response together with tachycardia, whereas N -terminal fragments induce hypertension and tachycardia and counteract the effect of the parent molecule (Gal-(1-29)) (Narvaez et al 1994). Furthermore, the N-terminal fragment (1-15) (GAL-(1-15)) blocks the In summary, increasing evidence supports the hypothesis that a chloride-dependent mechanism underlies the myogenic response, and may account for the depolarization seen in pressurized arteries.…”

Section: Institute Of Biomedical and Life Sciences Glasgow Universitmentioning

confidence: 99%

Cardiovascular/Respiratory Control

1998

The Journal of Physiology

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OntarioOxygen uptake (VO,) kinetics during the on-transient of moderate exercise are appreciably slower in older than in younger adults (Babcock et al. 1994), possibly because of reduced ability to deliver oxygen to the exercising muscle (Petrella et al. 1997 It is not known whether cold-induced vasodilatation (CIVD) in man (Lewis, 1930) is a local or central effect, or which part of the vascular bed is responsible (Sendowski et al. 1997). The present study was designed to provide information about this.

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Intracisternally injected galanin-(1–15) modulates the cardiovascular responses of galanin-(1–29) and the 5-HT1A receptor agonist 8-OH-DPAT

Cited by 34 publications

References 26 publications

Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit

Galanin inhibits calcium channels via Gαi-protein mediated by GalR1 in rat nucleus tractus solitarius

Cardiovascular/Respiratory Control

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