Intracorneal injection of a detachable hybrid microneedle for sustained drug delivery

Lee, KangJu; Song, Hyun Beom; Cho, Wonwoo; Kim, Jin Hyoung; Kim, Jeong Hun; Ryu, Wooseok

doi:10.1016/j.actbio.2018.09.039

Cited by 65 publications

(22 citation statements)

References 28 publications

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“…This is because certain medications and vaccinations are thermolabile, and micro forming allows for the preparation of needles in mild conditions [ 51 ]. Usually, hot embossing methods, investment molding, and injection molding are used to fabricate degradable and insoluble MNs, but due to relatively high processing temperatures, the drug activity may be easily affected [ 140 , 141 , 142 , 143 , 144 , 145 ]. The casting method is currently the most used method to prepare dissolvable polymer MNs due to the advantages of low processing temperature, convenient fabrication process, and insignificant impact on drug activity [ 145 , 146 ].…”

Section: Polymeric Microneedle Manufacturing Techniquesmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Section: Polymeric Microneedle Manufacturing Techniquesmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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“…The microneedle ocular patches containing amphotericin have also been found to be effective in treating fungal keratitis in rabbits ( Roy et al, 2019 ). Microneedle could deliver drugs into the corneal stroma by bypassing tear films and penetrating the corneal epithelium ( Lee et al, 2018 ). Several studies have reported the delivery of bioactive molecules or drugs using microneedle ocular patch for various applications, including keratitis.…”

Section: Ocular Drug Delivery Systems To Treat Keratitismentioning

confidence: 99%

“…In another study, Lee et al developed a detachable hybrid microneedle pen for delivering therapeutics to treat keratitis infections. Polyhexamethylene biguanide released into the cornea from detached poly(lactic-coglycolic) acid (PLGA) microneedle showed effective inhibition of Acanthamoeba -induced keratitis in mice models ( Lee et al, 2018 ).…”

Section: Ocular Drug Delivery Systems To Treat Keratitismentioning

confidence: 99%

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

et al. 2021

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Microbial keratitis is a leading cause of blindness worldwide and results in unilateral vision loss in an estimated 2 million people per year. Bacteria and fungus are two main etiological agents that cause corneal ulcers. Although antibiotics and antifungals are commonly used to treat corneal infections, a clear trend with increasing resistance to these antimicrobials is emerging at rapid pace. Extensive research has been carried out to determine alternative therapeutic interventions, and antimicrobial peptides (AMPs) are increasingly recognized for their clinical potential in treating infections. Small molecules targeted against virulence factors of the pathogens and natural compounds are also explored to meet the challenges and growing demand for therapeutic agents. Here we review the potential of AMPs, small molecules, and natural compounds as alternative therapeutic interventions for the treatment of corneal infections to combat antimicrobial resistance. Additionally, we have also discussed about the different formats of drug delivery systems for optimal administration of drugs to treat microbial keratitis.

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“…Recently, MNs have been applied not only to the skin but also to other organs, such as blood vessels [13,14,15], eyes [16,17,18,19,20], and so forth. An MN cuff applied to the outside surface of blood vessels as a perivascular drug delivery device to achieve high delivery efficiency to the tunica media has been introduced [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…For more advanced localized corneal drug delivery, a MN pen applicator coated with the drug was introduced [17]. Furthermore, with this pen-based platform, a MN was inserted to measure the puncture resistance and fracture toughness of porcine sclera [18]. At the posterior segment of the eye, MNs were shown to be able to deposit drugs into a narrow space between the sclera and the choroid [19].…”

Section: Introductionmentioning

confidence: 99%

Three-Step Thermal Drawing for Rapid Prototyping of Highly Customizable Microneedles for Vascular Tissue Insertion

et al. 2019

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Microneedles (MNs) have been extensively developed over the last two decades, and highly efficient drug delivery was demonstrated with their minimal invasiveness via a transdermal route. Recently, MNs have not only been applied to the skin but also to other tissues such as blood vessels, scleral tissue, and corneal tissue. In addition, the objective of the MN application has been diversified, ranging from drug delivery to wound closure and biosensing. However, since most MN fabrication methods are expensive and time-consuming, they are inappropriate to prototype MNs for various tissues that have different and complex anatomies. Although several drawing-based techniques have been introduced for rapid MN production, they fabricated MNs with limited shapes, such as thin MNs with wide bases. In this study, we propose a three-step thermal drawing for rapid, prototyping MNs that can have a variety of shapes and can be fabricated on curved surfaces. Based on the temperature control of polymer bridge formation during thermal drawing, the body profile and aspect ratios of MNs were conveniently controlled, and the effect of temperature control on the body profile of MNs was explained. Thermally drawn MNs with different shapes were fabricated both on flat and curved surfaces, and they were characterized in terms of their mechanical properties and insertion into vascular tissue to find an optimal shape for vascular tissue insertion.

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Intracorneal injection of a detachable hybrid microneedle for sustained drug delivery

Cited by 65 publications

References 28 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

Three-Step Thermal Drawing for Rapid Prototyping of Highly Customizable Microneedles for Vascular Tissue Insertion

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