Intracoronary and peripheral blood levels of TNF-like Cytokine 1A (TL1A) in patients with acute coronary syndrome

Chen, Xinjing; Guo, Yujin; Lai, Li; Zhang, Shengli; Li, Zhiliang

doi:10.1097/md.0000000000020305

Cited by 5 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SYNTAX score is a tool to risk stratify ACS patients based on anatomic features of coronary artery lesions. Nevertheless, it does not analyze clinical features and cannot realize the general characteristics of patients[ 17 - 22 ]. Therefore, this study discussed the significance of GRACE combined with SYNTAX scores for the assessment of prognosis of NSTE-ACS.…”

Section: Discussionmentioning

confidence: 99%

Value of GRACE and SYNTAX scores for predicting the prognosis of patients with non-ST elevation acute coronary syndrome

Zhao¹,

Liu²,

Sun³

2021

WJCC

View full text Add to dashboard Cite

BACKGROUND GRACE and SYNTAX scores are important tools to assess prognosis in non-ST-elevation acute coronary syndrome (NSTE-ACS). However, there have been few studies on their value in patients receiving different types of therapies. AIM To explore the value of GRACE and SYNTAX scores in predicting the prognosis of patients with NSTE-ACS receiving different types of therapies. METHODS The data of 386 patients with NSTE-ACS were retrospectively analyzed and categorized into different groups. A total of 195 patients who received agents alone comprised the medication group, 156 who received medical therapy combined with stents comprised the stent group, and 35 patients who were given agents and underwent coronary artery bypass grafting (CABG) comprised the CABG group. General information was compared among the three groups. GRACE and SYNTAX scores were calculated. The association between the relationship between GRACE and SYNTAX scores and the occurrence of major adverse cardiovascular events (MACEs) was analyzed. Pearson’s correlation analysis was used to determine the factors influencing prognosis in patients with NSTE-ACS. Univariate and multivariate analyses were conducted to analyze the predictive value of GRACE and SYNTAX scores for predicting prognosis in patients with NSTE-ACS using the Cox proportional-hazards model. RESULTS The incidence of MACE increased with the elevation of GRACE and SYNTAX scores (all P < 0.05). The incidence of MACE was 18.5%, 36.5%, and 42.9% in the medication group, stent group, and CABG group, respectively. By comparison, the incidence of MACE was significantly lower in the medication group than in the stent and CABG groups (all P < 0.05). The incidence of MACE was 6.2%, 28.0% and 40.0% in patients with a low GRACE score in the medication group, stent group, and CABG group, respectively ( P < 0.05). The incidence of MACE was 31.0%, 30.3% and 42.9% in patients with a medium GRACE score in the medication group, stent group, and CABG group, respectively ( P > 0.05). The incidence of MACE was 16.9%, 46.2%, and 43.8% in patients with a high GRACE score in the medication group, stent group, and CABG group, respectively ( P < 0.05). The incidence of MACE was 16.2%, 35.4% and 60.0% in patients with a low SYNTAX score in the medication group, stent group, and CABG group, respectively ( P < 0.05). The incidence of MACE was 37.5%, 40.9%, and 41.7% in patients with a medium SYNTAX score in the medication group, stent group, and CABG group, respectively ( P > 0.05). MACE incidence was 50.0%, 75.0%, and 25.0% in patients with a high SYNTAX score in the medication group, stent group, and CABG group, respectively ( P < 0.05). Univariate Cox regression analyses showed that both GRAC...

show abstract

Section: Discussionmentioning

confidence: 99%

Value of GRACE and SYNTAX scores for predicting the prognosis of patients with non-ST elevation acute coronary syndrome

Zhao¹,

Liu²,

Sun³

2021

WJCC

View full text Add to dashboard Cite

show abstract

“…McLaren et al [9] have demonstrated that TL1A promotes the formation of foam cell in vitro by regulating the levels of low-density lipoprotein and cholesterol that are involved in atherosclerosis. Recent evidences also demonstrated a relationship between serum TL1A and the occurrence of coronary artery disease and acute coronary syndrome [10,11] and serum TL1A might be a speci c biomarker for monitoring of coronary artery disease. In addition, TL1A can promote the expression of MiR-29b by activating the JNK-GATA3 signaling pathway [12] , and MiR-29b further mediated the down-regulation of extracellular matrix proteins, which played a key role in development of aortic dilatation and aortic aneurysm [13] .…”

Section: Introductionmentioning

confidence: 98%

The relationship between TNF-like protein 1A and coronary artery aneurysms in children with Kawasaki disease

et al. 2021

View full text Add to dashboard Cite

Background: Kawasaki disease (KD) is an acute, systemic vasculitis of unknown etiology that occurs predominantly in infants and children, and the most crucial complication of KD is coronary artery aneurysm (CAA). Tumor necrosis factor (TNF)-like protein 1A (TL1A) is a member of the TNF superfamily, which possesses the ability of maintaining vascular homeostasis and regulating immune response. This study aims to examine the serum TL1A levels in KD patients, and to investigate the relationship between TL1A and CAAs in children with KD.Methods: Blood samples were recruited from 119 KD patients, 35 febrile controls (FCs) and 37 healthy controls (HCs). The KD group was further divided into KD with CAAs (KD-CAAs) and KD non-CAAs (KD-NCAAs) groups. Serum TL1A levels were measured using enzyme-linked immunosorbent assays, and clinical parameters were collected in KD patients.Results: Serum TL1A levels in the acute phase of KD patients were signi cantly higher than that in the FC and HC groups. In particular, serum TL1A were substantially increased in the KD-CAA group than that in the KD-NCAA group. Furthermore, TL1A levels were positively correlated with the duration of fever, time point of IVIG and WBC levels, but negatively correlated with levels of RBC, Hb and Albumin in the KD group.Conclusions: TL1A might be involved in the KD-associated vasculitis, and might be a factor in the development process of CAAs.

show abstract

“…In the article, “Intracoronary and peripheral blood levels of TNF-like Cytokine 1A (TL1A) in patients with acute coronary syndrome”, [ 1 ] which appears in Volume 99, Issue 22 of Medicine , the author list appeared incorrectly as Xinjing Chen, Yansong Guo, and Shengli Zhang. The author list has since been corrected to Xinjing Chen, Yansong Guo, Shengli Zhang, and Zhiliang Li.…”

mentioning

confidence: 99%