Intracoronary Infusion of Allogeneic Mesenchymal Precursor Cells Directly After Experimental Acute Myocardial Infarction Reduces Infarct Size, Abrogates Adverse Remodeling, and Improves Cardiac Function

Abstract

their subpopulations might be more effective. [4][5][6] Mesenchymal precursor cells (MPCs) constitute a Stro-3 immune-selected, immature subfraction of bone marrow-derived MSCs. Objective: This study assessed the safety, feasibility, and efficacy of intracoronary delivery of allogeneic MPCs directly after acute myocardial infarction in sheep. Methods and Results:

Intracoronary Infusion of Encapsulated Glucagon-Like Peptide-1–Eluting Mesenchymal Stem Cells Preserves Left Ventricular Function in a Porcine Model of Acute Myocardial Infarction

“…33,34 Furthermore, the eMSC group shows a trend toward reduced fibrosis and improved myocardial viability in the infarct zone was observed, which could result in a reduction in total infarct size. 4,24,35 However, this effect was not statistically significant in our study, most likely based on limited numbers of animals. The trend toward less fibrosis could be explained by the secretion of immune-modulatory cytokines by MSC.…”

“…Several other preclinical and clinical studies have shown that under carefully controlled and monitored conditions, for example, slow infusion rate and low cell number, infusion of MSC or MSC-like stem cells or cardiospheres is well tolerated. 24,28,29 In the case of eMSC the same assumption could be made.…”

“…24,32 MSCs inside the alginate beads also have a proangiogenic effect. 33 Moreover, eMSC also improved angiogenesis in a hindlimb ischemia model and in porcine interposition grafts.…”

“…36 Alongside proangiogenic factors and immunomodulatory cytokines, MSCs secrete antiapoptotic factors that improve cell survival. 24,35 In addition, eMSCs in this study were transfected to secrete recombinant GLP-1. Exenatide, a GLP-1 analogue, has shown to reduce infarct size and improve cardiac function in a pig AMI model.…”

Cardiac patch design: compatibility of nanofiber materials prepared byelectrospinning method with stem cells

“…A study carried out with the cells of fetal cardiomyocytes transplanted into the damaged area showed that these cells could survive in the selected region, prevented the expansion of scar tissue, and stopped congestive heart failure (Benetti et al, 2010). Mesenchymal stem cells (MSCs) are the most commonly used cells for this purpose (Houtgraaf et al, 2013;Williams et al, 2013). Several molecules (cytokines, growth factors, and chemical agents) have been shown to regulate MSC differentiation into mesodermal lineages (osteoblasts, chondroblasts, adipocytes), including cardiomyocytelike cells (Celebi et al, 2010).…”