Intracortical Multidirectional Migration of Cortical Interneurons

Murakami, Fujio; Tanaka, Daichi; Yanagida, Mitsutoshi; Yamazaki, Emi

doi:10.1002/9780470994030.ch9

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within the cortex, interneurons contribute approximately 20% of the total neuronal complement. Cortical GABA-ergic interneurons are born in the ganglionic eminence, migrate tangentially into the cortical plate following well-defined pathways [81][82][83][84][85] , and then vertically into specific cortical layers 86,87 . In recent years, much work has focused on defining the signalling systems that may influence the migration of these cellsthese include such wellknown agents as Slit/Robo, Neuregulin/Erb4, semaphorin/neuropilin and BDNF and NT4 via TrkB receptors.…”

Section: The Ontogeny Of Cortical Gaba Interneuronsmentioning

confidence: 99%

The Neurodevelopmental Hypothesis of Schizophrenia

Piper

Beneyto

Burne

et al. 2012

Psychiatric Clinics of North America

View full text Add to dashboard Cite

The neurodevelopmental hypothesis of schizophrenia suggests that the disruption of early brain development increases the risk of later developing schizophrenia. This hypothesis focuses attention on critical periods of early brain development. From an epidemiologic perspective, various prenatal and perinatal risk factors have been linked to schizophrenia, including exposures related to infection, nutrition, and obstetric complications. From a genetic perspective, candidate genes have also been linked to altered brain development. In recent decades evidence from neuropathology has provided support for the neurodevelopmental hypothesis. Animal models involving early life exposures have been linked to changes in these same brain systems, providing convergent evidence for this long-standing hypothesis.

show abstract

Section: The Ontogeny Of Cortical Gaba Interneuronsmentioning

confidence: 99%

The Neurodevelopmental Hypothesis of Schizophrenia

Piper

Beneyto

Burne

et al. 2012

Psychiatric Clinics of North America

View full text Add to dashboard Cite

show abstract

“…In eutherians, the pallial SubV is an important site of production of projection neurons, mainly of the external cortical layers, but also some deeper neurons [Cheung et al, 2007;Molnár, 2011]. Studies in rodents indicate that glutamatergic projection neurons of the isocortex are derived from the pallial wall (VGZ and SubV) and migrate radially into position within the cortical plate [for reviews, see Kriegstein et al, 2006; 2011], whereas most GABAergic interneurons of the cortex are derived from the SubV of the ganglionic eminences and migrate tangentially over long distances to reach the cortical plate [Nadarajah and Parnavelas, 2002;Nadarajah et al, 2003;Carney et al, 2007;Murakami et al, 2007;Jones, 2009]. However, evolution of the primate cortex may have led to new forms of cortical interneurons with origins in the pallial neuroepithelium being added to an older population derived from the ganglionic eminences [Jones, 2009].…”

Section: The Putative Subv/subplate Developmental Zonementioning

confidence: 99%

Distinct Development of the Cerebral Cortex in Platypus and Echidna

Ashwell

Hardman²

2011

Brain Behav Evol

View full text Add to dashboard Cite

Both lineages of the modern monotremes have distinctive features in the cerebral cortex, but the developmental mechanisms that produce such different adult cortical architecture remain unknown. Similarly, nothing is known about the differences and/or similarities between monotreme and therian cortical development. We have used material from the Hill embryological collection to try to answer key questions concerning cortical development in monotremes. Our findings indicate that gyrencephaly begins to emerge in the echidna brain shortly before birth (crown-rump length 12.5 mm), whereas the cortex of the platypus remains lissencephalic throughout development. The cortices of both monotremes are very immature at the time of hatching, much like that seen in marsupials, and both have a subventricular zone (SubV) within both the striatum and pallium during post-hatching development. It is particularly striking that in the platypus, this region has an extension from the palliostriatal angle beneath the developing trigeminoreceptive part of the somatosensory cortex of the lateral cortex. The putative SubV beneath the trigeminal part of S1 appears to accommodate at least two distinct types of cell and many mitotic figures and (particularly in the platypus) appears to be traversed by large numbers of thalamocortical axons as these grow in. The association with putative thalamocortical fibres suggests that this region may also serve functions similar to the subplate zone of Eutheria. These findings suggest that cortical development in each monotreme follows distinct paths from at least the time of birth, consistent with a long period of independent and divergent cortical evolution.

show abstract

Intracortical Multidirectional Migration of Cortical Interneurons

Cited by 2 publications

References 0 publications

The Neurodevelopmental Hypothesis of Schizophrenia

The Neurodevelopmental Hypothesis of Schizophrenia

Distinct Development of the Cerebral Cortex in Platypus and Echidna

Contact Info

Product

Resources

About