Intracranial anatomic asymmetry in situs inversus totalis

Abstract

Situs inversus is a rare condition in which the position of the thoracic and the abdominal viscera are exchanged from the left to the right sides. A possible inversion of normal dominant intracranial anatomy, has however, rarely been discussed. We examine here the gross anatomy of an elderly cadaveric female for a possible "situs inversus" of the intracranial contents. This study has found that many structures commonly dominant on one side in the intracranial compartment were reversed in this specimen. These findings support the concept that a reversal of more commonly found intracranial anatomy may occur in situs inversus totalis, and this should alert the clinician performing invasive procedures in this population. These data will also hopefully provide further insight into possible mechanisms that contribute to situs inversus totalis.

Percutaneous coronary intervention in a patient with situs inversus and dextrocardia

“…The reason for this atypical presentation is not known. Situs inversus has been previously shown to be associated with abnormal neural axis development and this may lead to variant visceral pain perception (6). Our patient also the pain was located in the retrosternal and right anterior chest.…”

An extremely rare inversion of the preduodenal portal vein and common bile duct associated with multiple malformations

“…Further deviations of the developmental process were clearly involved. Recently, Tubbs et al (2003) reported that intracranial anatomic asymmetry in situs inversus totalis, and more researchers have suggested that situs inversus associated with left-right asymmetry, was likely to be due to genetic abnormalities in the left (Fujiwara et al 2002), nodal (Saijoh et al 2003), inv (Mochizuki et al 1998), Pitxz (Piedra et al 1998) and other genes (Yokoyama et al 1993). Further, the mechanism of other abnormalities such as PDPV and PDCBD are expected to be elucidated along with the elucidation of situs inversus at the level of molecular biology.…”

Neuroimaging study on brain asymmetries in situs inversus totalis

“…An interesting issue regarding such individuals is whether they have reversed brain asymmetries, which could provide a clue to elucidate the developmental mechanisms involved in brain asymmetries. Nevertheless, only few studies have focused on brain asymmetries in individuals with SI [15][16][17][18][19].…”