2023
DOI: 10.1001/jamanetworkopen.2023.10117
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Intracranial and Extracranial Progression and Their Correlation With Overall Survival After Stereotactic Radiosurgery in a Multi-institutional Cohort With Brain Metastases

Abstract: ImportanceClinical trials for metastatic malignant neoplasms are increasingly being extended to patients with brain metastases. Despite the preeminence of progression-free survival (PFS) as a primary oncologic end point, the correlation of intracranial progression (ICP) and extracranial progression (ECP) events with overall survival (OS) is poorly understood for patients with brain metastases following stereotactic radiosurgery (SRS).ObjectiveTo determine the correlation of ICP and ECP with OS among patients w… Show more

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Cited by 5 publications
(3 citation statements)
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“…In the context of comparing asymptomatic ITCP and SITCP (both requiring imaging documentation), this is less relevant compared with our prior work. 13 Overall, this retrospective study offers an exploratory and hypothesis-generating analysis and should be interpreted with caution until validated by future prospective cohort studies in the modern SRS setting.…”
Section: Discussionmentioning
confidence: 95%
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“…In the context of comparing asymptomatic ITCP and SITCP (both requiring imaging documentation), this is less relevant compared with our prior work. 13 Overall, this retrospective study offers an exploratory and hypothesis-generating analysis and should be interpreted with caution until validated by future prospective cohort studies in the modern SRS setting.…”
Section: Discussionmentioning
confidence: 95%
“…The same cohort of patients were used for prior studies of other prespecified clinical endpoints. 12 , 13 Informed consent waiver was granted because de-identified data were used. Exclusion criteria included age <18 years at time of SRS as well as prior SRS.…”
Section: Methodsmentioning
confidence: 99%
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