Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature

Brandão, Rafael Augusto Castro Santiago; Carvalho, Gervásio Teles Cardoso de; Reis, Baltazar Leão; Bahia, Enderson; Souza, Atos Alves de

doi:10.1016/j.surneu.2008.03.044

Cited by 35 publications

(16 citation statements)

References 13 publications

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“…The decision to treat these small, unruptured aneurysms was made - in 1 case, because of documented short-term growth of the aneurysm and, in the other case, because of planned bone marrow transplant (with its attendant large fluid volume and blood pressure shifts) - for attempted definitive treatment of the sickle cell disease. While previous reports have documented a proclivity for vertebrobasilar trunk aneurysms in patients with sickle cell disease [9,10,11,12], to the best of our knowledge this unusual location in particular has not been previously clearly described.…”

Section: Discussionmentioning

confidence: 54%

Intracranial Aneurysms in the Youngest Patients: Characteristics and Treatment Challenges

et al. 2015

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Background: Characteristics and treatment challenges of aneurysms in young children differ from those in older pediatric patients. Methods: Records of children undergoing cerebral or spinal angiography by the senior neurointerventionalist (D.B.O.) from October 2006 to January 2014 were reviewed to identify patients with digital subtraction angiography-confirmed intracranial aneurysms. Demographics, presentation, subtype of aneurysm, treatment strategy, and outcome were evaluated. Results: Of 763 pediatric cases, 33 were of children harboring cerebral aneurysms. Overall, 48% were male, 24% presented with hemorrhage and 67% harbored fusiform/dissecting aneurysms. Patients aged 0-10 years were significantly more likely to harbor nonsaccular, dissecting/fusiform aneurysms (84 vs. 43%, p = 0.02). A total of 13/22 pediatric patients harboring dissecting/fusiform aneurysms were male (59%) compared to 3/11 with saccular aneurysms (27%, p = 0.14). Overall, 15 patients underwent endovascular treatment (45%) and 8 underwent microsurgical treatment (24%). There was no significant difference in treatment approach based on patient age or aneurysm morphology. Overall, 19/23 aneurysms were occluded after initial treatment (83%); there were 2 procedure-related complications with neurological sequelae (9%). Conclusion: We demonstrate that the youngest patients (10 years and under) have aneurysms even more distinct and less similar to adult aneurysms than those in the larger pediatric cohort.

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Section: Discussionmentioning

confidence: 54%

Intracranial Aneurysms in the Youngest Patients: Characteristics and Treatment Challenges

et al. 2015

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“…Aneurysms are the most common identified cause of hemorrhagic stroke in adult patients with SCD [38]. Compared with patients without SCD, aneurysms in SCD patients are often multiple, have an increased propensity for the posterior cerebral circulation and may be prone to rupture at smaller sizes [39]. Moyamoya disease, a progressive stenosis of the internal carotid arteries resulting in the formation of fragile arterial collaterals, has been found to be present in 20-35% of the patients with SCD who undergo cerebral angiography [40].…”

Section: Hemorrhagic Strokesmentioning

confidence: 99%

Stroke in patients with sickle cell disease

Webb

Kwiatkowski

2013

Expert Review of Hematology

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“…Some patients develop a cerebral vasculopathy, including stenosis of the supraclinoid carotid arteries causing a moyamoya syndrome. There are several case reports 2,3 describing intracranial aneurysms and aneurysmal subarachnoid hemorrhage (SAH) and its management in patients with SCD, which were recently reviewed by Brandão et al 4 However, the prevalence of intracranial aneurysms and incidence of aneurysmal SAH in the sickle-cell population remain unclear; 2 recent publications indicate that intracranial aneurysms are indeed more common in SCD. 5,6 Patients with HbSS may be most at risk.…”

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confidence: 99%

Intracranial Aneurysms in Sickle-Cell Disease Are Associated With the Hemoglobin SS Genotype But Not With Moyamoya Syndrome

Birkeland

Gardner

Kesse‐Adu

et al. 2016

Stroke

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Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature

Cited by 35 publications

References 13 publications

Intracranial Aneurysms in the Youngest Patients: Characteristics and Treatment Challenges

Intracranial Aneurysms in the Youngest Patients: Characteristics and Treatment Challenges

Stroke in patients with sickle cell disease

Intracranial Aneurysms in Sickle-Cell Disease Are Associated With the Hemoglobin SS Genotype But Not With Moyamoya Syndrome

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