Intracranial atherosclerotic changes and apolipoprotein E in Japanese

Atherosclerotic changes in intracranial and extracranial large arteries in apparently healthy persons with asymptomatic lacunar infarction

“…Second, recent studies have suggested that lacunar or atherothrombotic infarction (or both) also may be related to other risk factors, such as hyperhomocysteinemia 26 and genetic polymorphisms. 27 In our previous investigation, 28 subjects with 4 of apolipoprotein E phenotype were frequently seen to have asymptomatic large-vessel disease on MRA or ultrasonography, although apolipoprotein E phenotype was not related to the appearance of ACI on MRI. Such novel risk factors in subjects with ACI may explain why ACI in the territories of perforating arteries is associated with large-vessel disease.…”