Intracranial bilateral symmetrical calcification on CT-scanning

Vakaet, A.; Rubens, Robert; Reuck, J. De; Eecken, H. vander

doi:10.1016/0303-8467(85)90106-4

Cited by 23 publications

(15 citation statements)

References 87 publications

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“…The most common reported type of BGC found on CT is bilateral, at the level of glo bus pallidus [4,6,8,13,17]. Associated calcifications have been described in the thalamus [10,17,18], cerebel lum [4,6,8,17,19], pons [17], white matter [13,17,19] and gray matter [13,17], In our patients globus pallidus and caudate were the two most frequent BGC locations. Thalamic calcifications were mainly seen in patients of group 2B (with OC).…”

Section: Discussionsupporting

confidence: 56%

“…Since 1979 several studies, primarily describing adult patients, have shown that computed tomography (CT) is more sensitive than plain skull radiography in identify ing BGC [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Although these calcifications are as sociated with multiple etiologies, no gross clinical symptoms are found in most patients.…”

Section: Introductionmentioning

confidence: 99%

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Significance of Basal Ganglia Calcification on Computed Tomography in Children

Legido

Zimmerman²,

Packer

et al. 1988

Pediatr Neurosurg

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We reviewed 6,428 head computed tomography (CT) scans performed on 4,283 children at our institution over a 3-year period and found basal ganglia calcification (BGC) in 48 (1.1%) of the patients. Their mean age at the time of detection was 5.3 years (range: 0.5–20 years); 16 (33%) patients had cancer, 14 (29%) had tuberous sclerosis or congenital infection and 18 (38%) had other medical conditions. All patients with cancer had been treated with radiation therapy, receiving a mean dose of 4,583 cGy (range: 1,800–5,500 cGy) to the diencephalon, and calcifications first became apparent at a median of 10 months after treatment. Other medical conditions included neonatal asphyxia (3), metabolic disease (3) (Kearns Sayre, MELAS, Krabbe’s), congenital anomalies (3), meningitis (2), Fahr’s disease (1) and others (6). Neurologic symptoms were common in children of all groups, but could not be correlated to BGC changes. Calcium and phosphorus metabolism was evaluated in 19 patients and was abnormal in 1. We conclude that BGC on CT in childhood occur primarily as an aftermath of the cancer treatment or in children with generalized neurologic dysfunction. Many children with BGC are delayed in their development, but calcifications are not directly related to specific forms of neurologic dysfunction. Rather, they appear to serve as markers for more extensive brain damage.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Significance of Basal Ganglia Calcification on Computed Tomography in Children

Legido

Zimmerman²,

Packer

et al. 1988

Pediatr Neurosurg

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“…The concrements observed here had a laminated appearance, showed no inflammatory response to mineral deposits and tended to occur near the blood vessels (Fig. 1), strikingly resembling brain mineralization in humans [16][17][18][19][20][21]. Collectively, this suggests that aged VDR knockout mice may represent a useful animal model of vitamin D/VDR-dependent intracranial calcification.…”

Section: Discussionmentioning

confidence: 54%

Thalamic calcification in vitamin D receptor knockout mice

et al. 2006

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Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies. These results are consistent with clinical findings showing brain calcification in patients with vitamin D deficiency. Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification.

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“…Most commonly involved are the first and fourth metacarpal and metatarsal bone. 1,5,6 Postoperative hypoparathyroidism is the most common complication of complete or near complete extirpation of thyroid gland by destruction or vascular compromise of parathyroid tissue. Several thyroid condition such as Grave's disease, thyrotoxicosis as a result of hyperactive thyroid adenoma, recurrent goiter, thyroid carcinoma carry a higher risk to develop transient and permanent hypoparathyroidism post operatively.…”

Section: Discussionmentioning

confidence: 99%

“…But patients can also present with laryngospasm, neuromuscular irritability, cognitive impairment, personality disturbances, prolonged QT interval or electrocardiographic changes that mimic myocardial infarcton and heart failure. 2,4,5 Intracranial calcification is one of the features of hypocalcaemia and the calcifications typically involve the basal ganglia, thalami and cerebellum. In our patient, calcinosis exceeds the common brain location and involves the subcortical white matters of frontal and parietal lobes.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Seizure: An Uncommon Presentation of Post Thyroidectomy Hypoparathyroidism

et al. 2015

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Basal ganglia calcification is associated with chronic hypoparathyroidism. We report a case of 37 year old lady with long standing iatrogenic hypoparathyroidism following total thyroidectomy. The clinical evaluation revealed neurological symptoms but without any neurological deficit. The CT scan of head showed calcification in caudate nucleus and part of lentiform nucleus of basal ganglia and in the cortical and subcortical white matter. Detection of brain calcinosis in patients who had total thyroidectomy can guide clinicians to further investigation for possible hypoparathyroidism.DOI: http://dx.doi.org/10.3329/jom.v16i1.22406 J MEDICINE 2015; 16 : 56-58

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Intracranial bilateral symmetrical calcification on CT-scanning

Cited by 23 publications

References 87 publications

Significance of Basal Ganglia Calcification on Computed Tomography in Children

Significance of Basal Ganglia Calcification on Computed Tomography in Children

Thalamic calcification in vitamin D receptor knockout mice

Recurrent Seizure: An Uncommon Presentation of Post Thyroidectomy Hypoparathyroidism

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