Intracranial Breakthrough Through Cavernous Sinus Compartments: Anatomic Study and Implications for Pituitary Adenoma Surgery

Abstract

BACKGROUND:Pituitary adenomas (PAs) with cavernous sinus (CS) invasion can extend into the intradural space by breaking through the CS walls.OBJECTIVE:To elaborate on the potential breakthrough route through CS compartments for invasive PAs and describe relevant surgical anatomy and technical nuances, with an aim to improve resection rates.METHODS:Twelve colored silicon-injected human head specimens were used for endonasal and transcranial dissection of the CS walls; ligaments, dural folds, and cranial nerves on each compartment were inspected. Two illustrative cases of invasive PA are also presented.RESULTS:The potential breakthrough routes through the CS compartments had unique anatomic features. The superior compartment breakthrough was delimited by the anterior petroclinoidal ligament laterally, posterior petroclinoidal ligament posteriorly, and interclinoidal ligament medially; tumor extended into the parapeduncular space with an intimate spatial relationship with the oculomotor nerve and posterior communicating artery. The lateral compartment breakthrough was limited by the anterior petroclinoidal ligament superiorly and ophthalmic nerve inferiorly; tumor extended into the middle fossa, displacing the trochlear nerve and inferolateral trunk to reach the medial temporal lobe. The posterior compartment breakthrough delineated by the Gruber ligament, petrosal process of the sphenoid bone, and petrous apex inferiorly, posterior petroclinoidal ligament superiorly, and dorsum sellae medially; tumor displaced or encased the abducens nerve and inferior hypophyseal artery and compressed the cerebral peduncle.CONCLUSION:The superior lateral and posterior components of the CS are potential routes for invasion by PAs. Better identification of CS breakthrough patterns is crucial for achieving higher gross total resection and remission rates.

Can Trigeminal Schwannomas in Middle Cranial Fossa Invade Cavernous Sinus

“…The breakthrough route through the lateral compartment (lateral triangle) is delimited by the anterior petroclinoidal ligament (APCL) superiorly and the V1 inferiorly. [30] TSs can invade the CS from outside to inside based on this anatomical relationship (thin inner membranous layer and lateral potential breakthrough location). We searched for previous studies on the relationship between TSs and CS.…”

Neurosurgery for the rhinologist

“…The cavernous ICA underlines two distinct compartments into the CS, medial and lateral. The medial compartment can be accessed through transsphenoidal EEAs [23 ▪▪ ,24,25,26 ▪ ], while the lateral through both EEAs and transcranial routes [27 ▪ ].…”

Efficacy of a Novel Augmented Reality Navigation System Using 3D Computer Graphic Modeling in Endoscopic Transsphenoidal Surgery for Sellar and Parasellar Tumors

“…During ETS for pituitary lesions, we identify anatomical landmarks in the sphenoid sinus such as the sella turcica, clival recess, optic canals, and carotid prominence, and the sellar floor can be safely opened to remove the tumor inside without special guidance from a neuronavigation system. When this surgical approach is expanded to tumors located in the skull base, comprehension of the surrounding anatomy becomes essential [ 6 , 7 , 8 , 9 , 10 , 11 ]. For endoscopic transsphenoidal skull base surgery, lesions as well as anatomic structures including cranial nerves, important cerebral structures, and critical vascular structures from the limited landmarks in the sphenoid sinus must be located simultaneously on imaging.…”