Intracranial carotid calcification on CT images as an indicator of atheromatous plaque: analysis of high-resolution CTA images using a 64-multidetector scanner

Suzuki, Michitaka; Ozaki, Yuka; Komura, Shinji; Nakanishi, Atsushi

doi:10.1007/s11604-007-0153-3

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…Secondly, the uniqueness of our study lies in the scanner technology, which has better visualization of arteries with calcified plaque or vessels located next to the skull bone than early CT [24,25]. In the present study, bone-subtraction CTA was simple and user-independent, and thereby it was more acceptable for routine clinical work than other noninvasive angiographies.…”

Section: Discussionmentioning

confidence: 86%

Noninvasive assessment of the carotid and cerebrovascular atherosclerotic plaques by multidetector CT in type-2 diabetes mellitus patients with transient ischemic attack or stroke

Jiang

et al. 2013

Diabetol Metab Syndr

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BackgroundThe cerebrovasuclar artery disease as a common complication of type-2 diabetes mellitus (T2DM) caused huge economic burden and lives threatening to patients. We evaluated the prevalence and morphology of carotid and cerebrovascular atherosclerotic plaques in T2DM patients with transient ischemic attack (TIA) or stroke using multidetector CT (MDCT).Methods64-MDCT and dual-source CT (DSCT) angiographies were performed in 195 T2DM patients with TIA or stroke (mean age 65.7+/-12.8 years; 118 men) between January 2009 to August 2011. During the process, plaque type, its distribution, extensive and obstructive natures were determined for each segment derived from the patients.ResultsAtherosclerotic plaques were detected in 183 (93.8%) patients. A total of 1056 segments with plaque were identified, of which 450 (42.6%) were non-calcified, 192 (18.2%) were mixed and 414 (39.2%) calcified ones. Among them, 562 (53.2%) resulted in mild stenosis, 291 (27.6%) moderate stenosis, 170 (16.1%) severe stenosis and 33 (3.1%) occlusion. Non-calcified plaques contributed 91.8% to non-obstructive lumen narrowing, while mixed and calcified plaques contributed 89.0% and 65.0% respectively.ConclusionsMDCT angiography detected a high prevalence of plaques in T2DM patients with TIA or stroke. A relatively high proportion of plaques were non-calcified, as well as with non-obstructive stenosis. MDCT angiography might further enhance the detection and management of carotid and cerebrovascular atherosclerosis in T2DM patients with TIA and stroke

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Section: Discussionmentioning

confidence: 86%

Noninvasive assessment of the carotid and cerebrovascular atherosclerotic plaques by multidetector CT in type-2 diabetes mellitus patients with transient ischemic attack or stroke

Jiang

et al. 2013

Diabetol Metab Syndr

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“…Several previous studies tested correlations between intracranial calcification and systemic diseases, 11 , 14 , 24 , 25 brain ischemic changes, 13 , 17 , 20 , 21 , 25 – 27 and carotid stenosis. 15 , 16 , 19 , 22 , 28 Only 2 studies compared visual calcium scoring and semiautomatic calcium volume measurement. 19 , 23 Bleeker et al 19 used CT angiography and categorized intracranial calcification visually into absent, mild, moderate, or severe (similar to Woodcock approach) and found good interobserver agreement for visual calcium score (linear-weighted κ=0.62; 95% confidence interval, 0.54–0.70), excellent interobserver agreement for semiautomatic quantitative calcium volume (Pearson correlation coefficient, 0.99; P <0.01; 95% limit of agreement 0.3±8.5 mm 3 ).…”

Section: Discussionmentioning

confidence: 99%

Intracranial Carotid Calcification on Cranial Computed Tomography

Subedi

Zishan

Chappell

et al. 2015

Stroke

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“…Intimal calcification is related to atherosclerotic luminal stenosis ( 10 ), a pivotal cause of territorial hypoperfusion and artery-to-artery embolism ( Figure 2 ) ( 75 ). Previous studies have revealed the correlation between luminal stenosis and the severity (thickness and circularity) of calcification in the intracranial ICA ( 76 , 77 ). In contrast, medial calcification seems to be more associated with vascular remodeling than luminal narrowing ( 78 ) in the vertebral artery and coronary artery ( 79 ).…”

Section: Clinical Relevance Of Iacmentioning

confidence: 99%

Histology-Verified Intracranial Artery Calcification and Its Clinical Relevance With Cerebrovascular Disease

Yang

Chen

2022

Front. Neurol.

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Intracranial artery calcification (IAC) was regarded as a proxy for intracranial atherosclerosis (ICAS). IAC could be easily detected on routine computer tomography (CT), which was neglected by clinicians in the previous years. The evolution of advanced imaging technologies, especially vessel wall scanning using high resolution-magnetic resonance imaging (HR-MRI), has aroused the interest of researchers to further explore the characteristics and clinical impacts of IAC. Recent histological evidence acquired from the human cerebral artery specimens demonstrated that IAC could mainly involve two layers: the intima and the media. Accumulating evidence from histological and clinical imaging studies verified that intimal calcification is more associated with ICAS, while medial calcification, especially the internal elastic lamina, contributes to arterial stiffness rather than ICAS. Considering the highly improved abilities of novel imaging technologies in differentiating intimal and medial calcification within the large intracranial arteries, this review aimed to describe the histological and imaging features of two types of IAC, as well as the risk factors, the hemodynamic influences, and other clinical impacts of IAC occurring in intimal or media layers.

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Intracranial carotid calcification on CT images as an indicator of atheromatous plaque: analysis of high-resolution CTA images using a 64-multidetector scanner

Cited by 11 publications

References 17 publications

Noninvasive assessment of the carotid and cerebrovascular atherosclerotic plaques by multidetector CT in type-2 diabetes mellitus patients with transient ischemic attack or stroke

Noninvasive assessment of the carotid and cerebrovascular atherosclerotic plaques by multidetector CT in type-2 diabetes mellitus patients with transient ischemic attack or stroke

Intracranial Carotid Calcification on Cranial Computed Tomography

Histology-Verified Intracranial Artery Calcification and Its Clinical Relevance With Cerebrovascular Disease

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