Intracranial cysts: incidental or neurodevelopmental?

Abstract

Intracranial cysts are uid-lled sacs within the brain. There is a diversity of intracranial cysts with different incidences in addition to the growing awareness about comorbidities and the consequences. The present study aimed to evaluate cystic ndings in children who were admitted to the department of pediatric neurology. Methods:Children who were admitted to the Clinic of Pediatric Neurology and who had an MRI between 2016-2021 evaluated. The MRI examination performed with pediatric epilepsy protocol. Primary intracranial cysts had been enrolled in the study. Demographic and clinical ndings had been evaluated from the hospital's database and patients' les Results:Among 78 patients 36(46,2%) were male and 42(53,8%) were female. The mean age was 7±5,4 years. The most frequent complaint of attendance was a seizure (47,4%). Approximately one over four () had mental and/or motor retardation. Nine (11,5%) of them had a neuropsychiatric diagnosis.Most of the cysts were located at the midline (41%). Mostly located extra-axial (71,8%) and supratentorial (78,2%). Most frequently arachnoid cysts had been observed with a percent of 64.1. The second leading type was pineal cysts(15.4%).The history of seizure, epilepsy, presence of mental retardation, and neuropsychiatric problems was evaluated according to the population ratios based on z approximation in which signi fantly higher rates had been observed among cases with intracranial cysts. Conclusion:Intracranial cysts should be taken into consideration for comorbid pathologies especially in childhood period. Early evaluation in patents with intracranial cysts for developmental delay and neuropsychiatric problems is important.

Management of Pediatric Cavum Cysts: A Scoping Review and a Single Institution Case Series

“…This is seen in our reported series where 10.6% (n = 2) of patients had either a congenital heart or CNS defect, 26.3% (n = 5) have intellectual disability, and 15.8% (n = 3) had other genetic conditions (Table 2). Although many anterior midline cysts are found incidentally, some present with symptoms of increased intracranial pressure, vomiting, nausea, headaches, and developmental delay [8,19]. In severe cases, anterior midline cysts can cause obstructive hydrocephalus [5,8,13].…”

“…Similarly to the other anterior midline cysts, cavum septum interpositum is usually seen in newborns [ 18 ]. Given that anterior midline cysts can be neurodevelopmental, there are many reports of comorbid genetic disorders, intellectual disability, seizures, and neuropsychiatric disorders [ 19 ]. This is seen in our reported series where 10.6% ( n = 2) of patients had either a congenital heart or CNS defect, 26.3% ( n = 5) have intellectual disability, and 15.8% ( n = 3) had other genetic conditions ( Table 2 ).…”

“…Although many anterior midline cysts are found incidentally, some present with symptoms of increased intracranial pressure, vomiting, nausea, headaches, and developmental delay [ 8 , 19 ]. In severe cases, anterior midline cysts can cause obstructive hydrocephalus [ 5 , 8 , 13 ].…”