Intracranial ependymomas: The role of advanced neuroimaging in diagnosis and management

Varrassi, Marco; Bellisari, Flavia Cobianchi; Donato, Maria Carmela De; Sibio, Alessandra Di; Bruno, Federico; Vitantonio, Hambra Di; Splendiani, Alessandra; Cesare, Ernesto Di; Masciocchi, Carlo

doi:10.1177/1971400921990770

Cited by 4 publications

(2 citation statements)

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“…In the ST group, studies have shown that YAP1 fusions foretell an excellent prognosis, with 5-year PFS and OS of 66 and 100%, respectively, whereas the presence of RELA fusions, which occurs in more than 70% of cases, correlates with some of the poorest outcomes (5 years PFS and OS of 29 and 75%, respectively) 4 . Despite this, these differences have not yet been translated into significant differences in the therapeutic management of these injuries 9 . Unfortunately, in the reported case, RELA fusion was not researched.…”

Section: Discussionmentioning

confidence: 99%

“…The most common are surface scanning, photogrammetry, computer tomography (CT) or magnetic resonance imaging (MRI) reconstruction, and digital modeling 7 . 3D models of anatomical structures are arising as important tools for surgery planning and medicine teaching [7][8][9] . This article, written following CARE guidelines, addresses the case of a 3-year-old female patient with recurrent supratentorial ependymoma and presents a unique 3D reconstruction model of the intracranial lesion, in order to discuss the surgical approach and the new possibilities offered by these technologies.…”

Section: Introductionmentioning

confidence: 99%

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Recurrence of supratentorial ependymoma in a brazilian child

Catão¹,

Debastiani²,

Everling³

et al. 2021

jbnc

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Ependymomas are tumors resulting from neoplasms in ependymal cells. They represent the third most common tumor of the central nervous system in pediatric patients, occurring more frequently intracranially, in addition to having a high rate of local recurrence. Three-dimensional reconstruction is an emerging technology that promises benefits to professionals, patients, and students. We report the case of a 3-year-old female patient with a recurrent left frontal ependymoma, as well as its unique 3D reconstruction. The primary lesion was clinically manifested by gait imbalance, and recurrence was identified by resonance magnetic imaging. This type of tumor requires resection surgery as main treatment, and total removal is associated with lower mortality and low recurrence rate. Despite that, in the present study, the primary lesion was partially resected, which represents a tendency to recurrence. The case was presented through a 3D reconstruction of the recurred intracranial lesion and the postoperative period, based on image exams of the patient, to discuss the surgical approach. In addition, the 3D model is an innovation that allows preoperative practice by neurosurgeons and improves the clinical understanding of the patient and their family by enabling the observation of structures. Also, it aids in medical education by ensuring 3D visualization, essential for the study of anatomy. Therefore, the present work adds to the scientific literature new possibilities offered by 3D reconstruction technology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recurrence of supratentorial ependymoma in a brazilian child

Catão¹,

Debastiani²,

Everling³

et al. 2021

jbnc

View full text Add to dashboard Cite

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Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long‐term outcome

Badary,

Kurdi,

Almealawy

et al. 2024

Aging Medicine

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ObjectiveEpendymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS) scores. This study evaluates clinical features, treatment outcomes, and factors affecting prognosis in patients with intracranial ependymomas.MethodsA retrospective review of 23 patients with intracranial ependymomas, treated from 2018 to 2023, was conducted. Data included demographics, clinical presentations, KPSS scores, imaging findings, and treatment details. Outcomes assessed were postoperative complications, recurrence rates, and functional status. Statistical analysis used SPSS version 26, with significance set at p < 0.05.ResultsThe cohort was predominantly male (87.0%), with a mean age of 27 years. Tumors were mostly in the fourth ventricle (82.6%), with an average diameter of 68.9 mm. Complete resection was achieved in 87.0% of cases. Postoperative radiotherapy was given to 91.0% of grade 2 and all grade 3 tumors. Recurrence occurred in 17.4% of grade 2 ependymomas, but none of grade 3. The seven‐month mortality rate was 4.3%. Higher preoperative KPSS scores correlated with better outcomes.ConclusionComplete tumor resection and postoperative radiotherapy are crucial for improved outcomes in ependymomas. Higher preoperative KPSS scores and tumor location significantly impact prognosis. Tumors in the lateral ventricles are associated with higher recurrence risks. These findings highlight the need for aggressive surgical management and personalized adjuvant therapy to enhance patient outcomes.

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