Intracranial extension of Schneiderian inverted papilloma: a case report and literature review

Pitak‐Arnnop, Poramate; Bertolini, Julia; Dhanuthai, Kittipong; Hendricks, Jörg; Hemprich, Alexander; Pausch, Niels Christian

doi:10.3205/000163

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…However, a significantly moderate positive correlation was observed between p53 and Ki-67 (Figure 4). HPV was detected in 26 (74.3%) patients, indicating the presence of one or two HPV genotypes (6,11,16,18). Additionally, 9 patients (25.7%) tested negative for HPV.…”

Section: Resultsmentioning

confidence: 99%

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Human papillomavirus expression in relation to biological behavior, Ki-67 proliferative marker, and P53 prognostic marker in Schneiderian papilloma

Mohsin,

Al-Drobie

2023

JMedLife

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Various malignant and benign tumors can arise in the sinonasal cavity, including inverted papilloma (IP), a benign neoplasm with unique clinical characteristics. However, the mechanisms involved in the recurrence, occurrence, and malignant transformation of IP remain debatable. This study aimed to investigate the impact of human papillomavirus (HPV) infections on IP by comparing the number of infections in cases with epithelial tissue dysplasia and explore the predictive role of proliferative and prognostic markers in dysplasia. Tissue blocks from 35 cases of sinonasal papilloma, collected between 2015 and 2021 from the laboratory archives of the Medical City of Ghazi Al-Hererri Hospital in Baghdad, Iraq, were immunohistochemically stained with monoclonal antibodies (mAbs) to detect Ki-67 and p53. A quantitative immunohistochemical analysis was conducted to analyze the results. Polymerase chain reaction (PCR) was performed to detect HPV genotypes 16/18 and 6/11 in the tissues. There was an insignificant increase in Ki-67 and p53 expression in inverted papillomas with dysplasia. HPV11 was the most prevalent genotype in 34.3% of the patients, followed by HPV16 and HPV18 in 31.4% of the patients for each virus. The least common virus detected was human papillomavirus 6 (8.6%), which did not show any significant association with the degree of dysplasia. Viral detection proliferation and apoptosis had no impact on tumor dysplasia amongst all the patients, showing no relationship with the evaluated cases.

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Section: Resultsmentioning

confidence: 99%

“…Thus, dysplasia is a key histopathological finding in sinonasal papillomas and should be mentioned in surgical pathology reports. While dysplasia has been observed in ISP and OSP, it is not well described in ESP [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus expression in relation to biological behavior, Ki-67 proliferative marker, and P53 prognostic marker in Schneiderian papilloma

Mohsin,

Al-Drobie

2023

JMedLife

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“…Inverted papillomas (IPs) are benign tumours arising from the Schneiderian mucosa of the nasal cavity and paranasal sinuses with either single or multifocal sites of origin [ 1 ]. Clinically, patients with IPs present with unilateral sinonasal symptoms such as nasal obstruction and are classically found to have “unilateral nasal polyps” on nasal endoscopy [ 2 – 4 ]. Although IPs are benign tumours, the malignant transformation rate ranges from 5 to 15%, necessitating complete surgical resection and continued surveillance [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: A retrospective review

Grose

Lee

et al. 2023

Journal of Otolaryngology - Head & Neck Surgery

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Background Sinonasal inverted papillomas (IP) are benign tumours arising from the mucosal lining of the nasal cavity and paranasal sinuses with a high propensity for recurrence and malignant transformation. Advances in endoscopic surgery and improved radiologic navigation have increased the role of endoscopic surgical resection in the treatment of IPs. The current study aims to evaluate the rate of IP recurrence after endoscopic endonasal resection and to evaluate factors which impact recurrence. Methods This was a single-centre retrospective chart review of all patients who underwent endoscopic sinus surgery for management of IP between January 2009 and February 2022. Primary outcomes were the rate of IP recurrence and time to IP recurrence. Secondary outcome measures were patient and tumour factors that contributed to IP recurrence. Results Eighty-five patients were included. The mean age was 55.7 and 36.5% of patients were female. The mean follow-up time was 39.5 months. Of the 85 cases, 13 cases (15.3%) had recurrence of their IP and the median time to recurrence was 22.0 months. All recurrent tumours recurred at the attachment site of the primary tumour. The univariate analysis did not identify any significant demographic, clinical, or surgical predictors of IP recurrence. There were no significant changes in sinonasal symptoms at the time IP recurrence was detected. Conclusion Endoscopic endonasal resection of IPs represents an effective surgical approach, however, the relatively high rate of recurrence and lack of symptomatic changes at the time of recurrence necessitates long term follow up. Better delineation of risk factors for recurrence can help identify high-risk patients and inform postoperative follow up strategies.

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The prevalence of human papillomavirus infection in Iranian patients with sinonasal inverted papilloma

Jalilvand

Saidi

Shoja

et al. 2016

Journal of the Chinese Medical Association

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Intracranial extension of Schneiderian inverted papilloma: a case report and literature review

Cited by 8 publications

References 38 publications

Human papillomavirus expression in relation to biological behavior, Ki-67 proliferative marker, and P53 prognostic marker in Schneiderian papilloma

Human papillomavirus expression in relation to biological behavior, Ki-67 proliferative marker, and P53 prognostic marker in Schneiderian papilloma

Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: A retrospective review

The prevalence of human papillomavirus infection in Iranian patients with sinonasal inverted papilloma

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