Intracranial fetus‐in‐fetu with numerous fully developed organs

Traisrisilp, Kuntharee; Srisupundit, Kasemsri; Suwansirikul, Songkiet; Norasetthada, Thunya; Kosarat, Shanika; Tongsong, Theera

doi:10.1002/jcu.22566

Cited by 18 publications

(13 citation statements)

References 23 publications

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“…Contrary to this report, Traisrisilp et al 16 found a female fetus with intracranial fetal organ structure associated with hydrocephalus. In that case, the pathological examination confirmed the diagnosis of FIF.…”

Section: /6contrasting

confidence: 77%

Case report: rare congenital anomaly diagnosed by ultrasonography

Moraes¹,

Marques²,

Tacon³

et al. 2019

Hum. Reprod. Arch.

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Objectives: Report a rare congenital anomaly diagnosed by obstetric ultrasound. Methods: The pregnant woman suspected of have fetus with congenital anomaly was attended in the fetal medicine service of a public maternity hospital in Goiás, Brazil. A hyperechogenic nodule in the mesoabdomen of a male fetus were observed through ultrasonography. The totipotent cell mass was withdrawn one week postpartum. The anatomopathological analysis performed confirmed fetal tissue type FIF. Results: The ultrasonography performed at the institution detected the presence of a hyperechogenic nodule with 2cm shade in the mesoabdomen of a male fetus, performed at the 30th week of gestation. The totipotent cell mass was withdrawn during labor. It had bones and limbs under development. This pathology is due to abnormal embryogenesis. In these cases, a vertebrate fetus is enclosed within the body of another normally developed fetus and kept by a pedicle in an area filled with liquid or sebaceous material, with no placental or chorionic tissue. Intrauterine growth of FIF is initially similar to its twin, with its subsequent arrested development in a precipitate way due to the "host's" vascular domain or an inherent defect of the "parasitic" twin. The entity is rare and interesting, typically presented in childhood or early childhood. Conclusions: Current imaging modalities, such as pre and postnatal ultrasonography, can accurately diagnose the condition. Complete excision is curative and allows confirmation of the diagnosis.

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Section: /6contrasting

confidence: 77%

Case report: rare congenital anomaly diagnosed by ultrasonography

Moraes¹,

Marques²,

Tacon³

et al. 2019

Hum. Reprod. Arch.

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“…FIF is a condition, commonly occurs in retroperitoneal space (80%) 2. Others rare sites like sacrococcygeal region, intracranial, thorax, pelvis, scrotum, back and oral cavity have also been described in the literature 3–5. There are two theories for the development of FIF.…”

Section: Discussionmentioning

confidence: 99%

Fetus in fetu in an adult woman

Kumar¹,

Paswan

Kumar

et al. 2019

BMJ Case Rep

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Fetus in fetu (FIF) is an extremely rare condition in which malformed fetus is found most commonly in the retroperitoneum of living twin. It occurs in about 1 in 500 000 live births and less than 200 cases have been reported in medical literature. We report FIF in a 17-year-old woman unlike other cases which were usually detected in early age and in male gender. This is the eighth case of adult FIF and the first case of FIF in adult woman worldwide. Preoperative diagnosis of FIF on CT was made and planned for exploratory laparotomy. The excised malformed fetus in a sac was proven as FIF on the basis of histopathological examination. In view to avoid such late presentation, early detection of FIF with radiological imaging in clinically suspected case is recommended. Surgical excision is the ideal treatment even teratoma is the differential diagnosis.

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“…FIF often show characteristic human development with presence of organs, tissues, and/or hair. They are mostly found in the retroperitoneum, but can also be found in the abdominal cavity, cranial cavity, sacrum, mediastinum, scrotum, oral cavity, kidneys, and even as cryptorchidism (1,(9)(10)(11). Clinically, it typically manifests as abdominal distension and a painless mass in the abdomen.…”

Section: Introductionmentioning

confidence: 99%

Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center

Mao

Lingxi²,

Song³

et al. 2021

Front. Pediatr.

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Objective: Fetus-in-fetu (FIF) is an extremely rare disease, and most prior publications are single case reports. Here, we describe the clinical characteristics, imaging manifestations, and the treatment and related complications of FIF from a large tertiary pediatric referral center.Materials: After institutional review board approval, patients with a diagnosis of FIF between January 2010 and November 2019 were further selected and reexamined. We analyzed the general clinical characteristics, imaging manifestations, treatment, and prognosis of the patients.Results: A total of seven (four male and three female) patients with FIF were included in the study. All patients were diagnosed with FIF during the antenatal ultrasound examination along with an abnormal increase in alpha fetoprotein, and it was confirmed by subsequent pathological examination. The median gestation period when FIF was first diagnosed was 25 (range: 22–32) weeks. Ultrasound, computed tomography, and magnetic resonance imaging were the main pre-operative diagnostic techniques used. All patients underwent FIF resection within 1 month after birth: four patients had open surgery and three had laparoscopic surgeries (one case was converted to open surgery); only one patient developed ascites after surgery. All patients are growing up healthy and without tumor recurrence at the last follow-up. The level of alpha fetoprotein decreased to normal within 1 year (range 3-10 months) after surgery performed.Conclusion: As the size of the FIF increases, it can be found and diagnosed in antenatal ultrasound examination. Surgery is an important curative treatment for FIF and generally results in excellent long-term quality of life.

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Intracranial fetus‐in‐fetu with numerous fully developed organs

Cited by 18 publications

References 23 publications

Case report: rare congenital anomaly diagnosed by ultrasonography

Case report: rare congenital anomaly diagnosed by ultrasonography

Fetus in fetu in an adult woman

Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center

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