Intracranial germ-cell tumours — treatment results and residuals

Haupt, Claudia; Ancker, Ulrike; Müller, Mark; Herrmann, H. D.; Schulte, F. J.

doi:10.1007/bf01953944

Cited by 9 publications

(3 citation statements)

References 32 publications

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“…However, due to diffuse infiltration of the peritumorous venes in the 4th case with a malignant teratoma, only subtotal removal was achieved. In our overall series of 17 children with intracranial germ cell tumors, severe postoperative morbidity was observed neither after subtotal (n = 7) nor after total (n = 10) tumor removal [16].…”

Section: Discussionmentioning

confidence: 99%

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Treatment and Long-Term Outcome of Pineal Nongerminomatous Germ Cell Tumors

Knappe

Bentele²,

Horstmann³

et al. 1998

Pediatr Neurosurg

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In 1994 we reported on a small series of 3 children with malignant, marker-positive pineal nongerminomatous germ cell tumors treated with a ‘sandwich’ protocol. Here, we report on the long-term survival of these children. Preoperative chemotherapy consisted of two courses of bleomycin, etoposide, and cisplatin. En bloc resection of the tumors via the supracerebellar, infratentorial route was performed immediately after decline of tumor marker levels. Postoperatively, two courses of vinblastine, ifosfamide, and cisplatin were applied, followed by craniospinal irradiation. The patients showed no major neurological deficits and no evidence (neuroradiologically or with regard to tumor marker levels) of recurrence of disease after 66, 71, and 78 months, respectively. We propose this regimen for children with tumors of the pineal region in whom the tumor markers are positive. It should be started without histological classification of the tumor to avoid possible spillage of malignant tumor cells to the cerebrospinal fluid.

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Section: Discussionmentioning

confidence: 99%

“…Since intracranial marker-positive nongerminomatous germ cell tumors are a rare entity, and even in large series of intracranial germ cell tumors constitute only a few cases [5,15,16], experience with their treatment is limited in any center. Therefore, the creation of a central register for this kind of tumors seems to be desirable.…”

Section: Discussionmentioning

confidence: 99%

Treatment and Long-Term Outcome of Pineal Nongerminomatous Germ Cell Tumors

Knappe

Bentele²,

Horstmann³

et al. 1998

Pediatr Neurosurg

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“…Intracranial germ cell tumours are rare brain tumours and occur in 3–11% of children and adolescents with malignant CNS tumours, with a higher incidence in eastern countries [2, 7, 8]. Germinomas account for about 65% and teratomas for 20–30% of intracranial germ cell tumours, while choriocarcinomas, yolk sac tumours, or embryonal carcinomas are only found in up to 1% of the patients [2, 8].…”

Section: Discussionmentioning

confidence: 99%

Gonadotrophin-Independent Puberty in a Boy with a β-HCG-Secreting Brain Tumour

Marx¹,

Beck²,

Grabenbauer

et al. 2000

Horm Res Paediatr

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We report on a short-statured boy in whom therapy with recombinant human growth hormone was initiated at the age of 9.7 years for assumed idiopathic growth hormone deficiency. On recombinant human growth hormone, height improved from –1.9 (standard deviation score) to –0.9 within 1 year, and the patient entered puberty spontaneously at 10.7 years. At 11.6 years he showed low morning cortisol and thyroxine levels, but was otherwise well. He showed an inconspicuous growth, and puberty progressed adequately until the age of 13.4 years, when he developed signs of an increased intracranial pressure, and a suprasellar choriocarcinoma was diagnosed. This case confirms the fact that beta chorionic gonadotrophin secreting tumours will not be diagnosed by the characteristic clinical manifestation of gonadotrophin-independent puberty if they occur at a time when normal puberty is expected. Particularly, it raises the question of how often the CNS should be re-evaluated by magnetic resonance imaging in children with growth hormone deficiency and normal initial neuroradiological imaging, when they develop additional hormonal deficiencies but no other clinical symptoms of an intracranial process.

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Puberty

Styne¹,

Grumbach²

2011

Williams Textbook of Endocrinology

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Intracranial germ-cell tumours — treatment results and residuals

Cited by 9 publications

References 32 publications

Treatment and Long-Term Outcome of Pineal Nongerminomatous Germ Cell Tumors

Treatment and Long-Term Outcome of Pineal Nongerminomatous Germ Cell Tumors

Gonadotrophin-Independent Puberty in a Boy with a β-HCG-Secreting Brain Tumour

Puberty

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