Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism

Guedes, Bruno Fukelmann; Souza, Marcio Nattan Portes; Barbosa, Breno José Alencar Pires; Frassetto, Fernando Pereira; Lucato, Leandro Tavares; Ono, Carla Rachel; Castro, Luiz Henrique Martins; Nitrini, Ricardo; Simabukuro, Mateus Mistieri

doi:10.1136/practneurol-2017-001771

Cited by 3 publications

(1 citation statement)

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“…Hypopituitarism may be caused by intracranial GCTs. 34 In our study, a low IGF-1 level or growth hormone deficiency was the most common symptom, followed by adrenal insufficiency. Nearly half of our patients had DI, and a few patients already received desmopressin therapy because no tumor was found in previous brain MRI.…”

Section: Discussionmentioning

confidence: 47%

Neurological and endocrinological manifestations of 49 children with intracranial pure germinoma at initial diagnosis in Taiwan

Chang

Chiu

Jung

et al. 2021

Pediatrics & Neonatology

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Background: Intracranial pure germinoma is a rare extragonadal neoplasm. Affected patients may have motor impairment, visual disturbance, neurological signs, and endocrine disorder, depending on the size and location of the tumor. This study investigated and analyzed patients' demographic data and neuroimaging, clinical, laboratory, and endocrinological findings. Methods: We performed a retrospective chart review of 49 children diagnosed with pure germinoma in Taiwan from 1990 to 2018. The initial clinical presentation, tumor markers (beta-hCG, alpha fetoprotein, and carcinoembryonic antigen), pituitary function, and brain images were reviewed and analyzed. Results: This study included 49 patients (37 boys and 12 girls). Their ages ranged from 7.5 to 17.9 years, and the mean age at diagnosis was 13.6 years. Initial symptoms included visual disturbance (n Z 23, 47.9%), motor impairment (n Z 20, 40.8%), polyuria (n Z 20, 40.8%), headache (n Z 17, 34.7%), dizziness or vertigo (n Z 14, 28.6%), nausea/vomiting (n Z 13, 26.5%), and short stature (n Z 8, 18.2%). Laboratory data indicated growth hormone deficiency or low IGF-1 levels (n Z 18, 85.7%), adrenal insufficiency (n Z 21, 77.8%), central diabetes insipidus (n Z 27, 55.1%), central hypothyroidism (n Z 15, 48.4%), and hypogonadotropic

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Section: Discussionmentioning

confidence: 47%