Intracranial hemangiopericytoma: Radiology, surgery, radiotherapy, and outcome in 21 patients

Jääskeläinen, Juha E.; Servo, Antti; Haltia, Matti; Wahlström, Torsten; Valtonen, S.

doi:10.1016/0090-3019(85)90087-4

Cited by 180 publications

(130 citation statements)

References 8 publications

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“…24 Resection is the initial treatment of choice, 26 but the highly vascular nature of the lesion and the location of some along the skull base results in mortality rates between 9 and 24%. 12,14,23,25 Furthermore, the median time from resection to recurrence is 12 months, 8 and distant metastases have been noted to appear between a mean of 63 and 99 months after initial diagnosis. 7,12,14,23,25 Because of the recurrent nature of these lesions, exter-S. D. Chang and G. T. Sakamoto nal-beam radiotherapy has been used in the postoperative setting.…”

Section: Discussionmentioning

confidence: 99%

“…12,14,23,25 Furthermore, the median time from resection to recurrence is 12 months, 8 and distant metastases have been noted to appear between a mean of 63 and 99 months after initial diagnosis. 7,12,14,23,25 Because of the recurrent nature of these lesions, exter-S. D. Chang and G. T. Sakamoto nal-beam radiotherapy has been used in the postoperative setting. Dube and Paulson 6 reported one of the first radiotherapy-based treatments of a hemangiopericytoma, noting a complete response.…”

Section: Discussionmentioning

confidence: 99%

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The role of radiosurgery for hemangiopericytomas

Chang

Sakamoto²

2003

FOC

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Object Hemangiopericytomas represent a small subset of meningeal tumors. Despite their relatively uncommon nature, they are aggressive tumors known for recurrence. Resection is the standard treatment in most, although regrowth and metastases are common even after resection. The authors evaluate the role of stereotactic radiosurgery in the treatment of recurrent hemangiopericytomas. Methods In a review of the Stanford radiosurgery patient database between 1989 and 2002, the authors found eight patients with recurrent hemangiopericytoma who underwent stereotactic radiosurgery. The mean age of this population was 45.1 years (range 24–67 years). All patients had been previously treated with resection, and five patients (63%) had undergone conventional radiotherapy. The mean radiosurgery dose to the tumor margin was 20.5 Gy (range 16–24 Gy). The mean clinical and radiographic follow-up period was 44 months (range 8–77 months). Of the eight tumors treated with radiosurgery, six decreased in size and two ultimately progressed. There were no radiosurgery-related complications. Conclusions Stereotactic radiosurgery of hemangiopericytomas can result in increased tumor control and should be considered as a treatment option for patients in whom the diagnosis has been established and in whom residual tumor is demonstrated postoperatively. Close clinical and radiographic follow-up evaluation is necessary in this patient population because of the high rate of local recurrence and distant metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of radiosurgery for hemangiopericytomas

Chang

Sakamoto²

2003

FOC

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“…7,[11][12][13]21,25 The response of HPCs to radiotherapy is dose dependent, with overall treatment doses of 45 Gy or higher resulting in superior local control. 6 The current SRT treatment plan used in most centers delivers 46-52 Gy fractionated over [25][26][27][28][29][30][31][32][33][34][35] sessions.…”

Section: Multimodal Managementmentioning

confidence: 99%

Hemangiopericytomas of the skull base

Schirmer¹,

Heilman²

2011

FOC

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Object Intracranial hemangiopericytomas are frequently located along the dural sinuses along the skull base and represent rare, aggressive CNS neoplasms that are difficult to distinguish from meningiomas based on both imaging and gross characteristics. The authors of this study describe 3 patients with these lesions and review the pertinent literature. Methods Two men and 1 woman, whose median age at the time of the initial presentation was 37 years (range 20–53 years), constitute this series. They underwent multimodal treatment consisting of resection, embolization, radiation therapy, and in 1 case chemotherapy. Results Two of the 3 patients treated were alive after a mean follow-up of 93 months (range 4–217 months). One patient died 217 months after the initial diagnosis. The longest tumor progression–free interval after the initial or secondary resection was 43 months (range 4–84 months). Conclusions Hemangiopericytomas have been reclassified as mesenchymal nonmeningothelial tumors. They have an inevitable tendency to recur locally and metastasize distally. The mainstay of therapy remains an aggressive attempt to achieve gross-total resection at the initial surgery. Postoperative adjuvant radiotherapy should be offered to all patients, regardless of the degree of resection achieved. Diligent long-term follow-up is paramount as local recurrences and distal metastases can develop sometimes years after the initial treatment.

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“…1,8,10,12) Hemangiopericytomas constitute less than 1% of all CNS tumors and are often classified as angioblastic meningiomas. 3,6,10,14) The most common extraneural metastatic sites are the bone and lung, and the 10-and 15-year rates of metastasis are 33% and 64%, respectively. 3,9,10,15) We describe a rare case of pancreatic metastasis discovered 22 years after the diagnosis of the primary tumor.…”

Section: Introductionmentioning

confidence: 99%

Intracranial Hemangiopericytoma With Extracranial Metastasis Occurring After 22 Years. Case Report.

Suzuki

Haga

Oguro

et al. 2002

Neurol. Med. Chir.(Tokyo)

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A 65-year-old man developed pancreatic and pubic tumors 22 years after craniotomy for a left sphenoid ridge tumor. The histological finding of the primary sphenoid ridge tumor was meningotheliomatous meningioma. The histological appearance of the biopsy specimen of the pubic tumor was hemangiopericytoma. The recurrent intracranial tumor was treated by radiosurgery, and the metastatic tumors were treated by conventional irradiation. Intracranial tumors rarely metastasize outside the central nervous system, except for meningeal hemangiopericytomas. This case indicates that meningeal hemangiopericytoma may metastasize many years after the initial onset and requires long-term follow up.

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Intracranial hemangiopericytoma: Radiology, surgery, radiotherapy, and outcome in 21 patients

Cited by 180 publications

References 8 publications

The role of radiosurgery for hemangiopericytomas

The role of radiosurgery for hemangiopericytomas

Hemangiopericytomas of the skull base

Intracranial Hemangiopericytoma With Extracranial Metastasis Occurring After 22 Years. Case Report.

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