Intracranial Hemorrhage in a Previously Healthy Infant

Bruton, Lucas; Hoffmann, Jennifer A.

doi:10.1016/j.cpem.2020.100763

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Of the 28 studies with bile duct obstruction or cholestatic syndromes, biliary atresia was the most frequent diagnosis ( n = 107) and the children were primarily ( n = 73) scanned at diagnosis (age 0–6 months) 5,11–14,19–41 The most common brain pathology was haemorrhage seen on an MRI, CT or US 11,12,22–32 . Haemorrhage was only seen at diagnosis (age 0–6 months) and was present in 54 cases where 14 had intraparenchymal, 2 had intraventricular, 14 had subdural, 7 had subarachnoid and 25 had unspecific intracranial haemorrhage.…”

Section: Resultsmentioning

confidence: 99%

Brain imaging in children with neonatal cholestatic liver disease: A systematic review

Helt,

Johansen,

Faurholt‐Jepsen

et al. 2024

Acta Paediatrica

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AimTo determine if children with neonatal cholestatic liver disease had concurrent and later findings on brain imaging studies that could be attributed and the cholestasis to contribute to the understanding of the impaired neuropsychological development.MethodsOvid MEDLINE and EMBASE were searched on July 21, 2022, and updated on March 26, 2023. Studies with children under 18 years of age with neonatal cholestasis and a brain scan at the time of diagnosis or later in life were included. Excluded studies were non‐English, non‐human, reviews or conference abstracts. Data were extracted on demographics, brain imaging findings, treatment and outcome. The results were summarised by disease categories. Risk of bias was assessed using JBI critical appraisal tools.ResultsThe search yielded 12 011 reports, of which 1261 underwent full text review and 89 were eligible for inclusion. Haemorrhage was the most common finding, especially in children with bile duct obstruction, including biliary atresia. Some findings were resolved after liver transplantation.ConclusionChildren with neonatal cholestasis had changes in brain imaging, which might play a role in impaired neuropsychological development, but longitudinal clinical research with structured assessment is needed to better qualify the aetiology of the impairment.

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Section: Resultsmentioning

confidence: 99%